How to scale advanced 3D cell culture workflows with automated liquid handling

10 Aug 2026
Charlie Carter
Life Sciences Editor
Scale advanced 3D cell culture workflows with automated liquid handling - SelectScience eBook

Advanced cell culture models, including 3D cell cultures, hydrogels, organoids, and iPSC-derived cultures, provide more physiologically relevant results than traditional 2D models. However, routine processes such as matrix preparation, media exchange, cell feeding, and sample collection can be difficult to perform consistently, introducing variability and impacting experimental outcomes.

As labs adopt more standardized and automated cell culture workflows, liquid handling becomes essential for improving reproducibility, efficiency, and throughput. This is especially important when working with sensitive cell cultures, viscous matrices, and temperature-sensitive reagents.

In this SelectScience eBook, discover how INTEGRA Biosciences' automated liquid handling solutions help streamline advanced cell culture workflows, supporting reproducible handling of 3D cultures, organoids, stem cells, and iPSC-derived models while enabling consistent media exchange, cell maintenance, and sample collection at scale.

Download this SelectScience liquid handling guide to explore how to:

  • Automate media exchange and sample collection
  • Standardize matrix preparation
  • Miniaturize library preparation
  • Extend gentle automation to sensitive cell workflows

Resource details:

  • Document type: SelectScience application eBook
  • Page count: 43
  • Read time: 65 mins
  • Edition: 1st

Links

Tags

Automated Liquid HandlingAutomated liquid handling equipment is used to mix, dilute and dispense allotted volumes of liquid into microplates and other vessels automatically. The robotic, liquid handling arms can dispense from single channel to 3456 multichannel as well as operate nanoliter dispensing, enabling high throughput of samples. Find the best automated liquid handlers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.3D Cell CultureCulturing cells in three dimensions allows more physiologically relevant observations to be made regarding cellular interactions and gene expression. 3D models provide a more accurate representation of cells in vivo and are more stable than 2D cultures, making them very useful for long-term studies.