iLite® Fc Effector Activity Bioassays
The iLite® Fc Effector Reporter Gene Bioassays Portfolio offers a variety of reporter gene cell lines and target cells that can be used in MOA-reflective assays to measure the Fc effect of antibodies and other biologics that specifically bind and activate Fc receptors. Using a Luciferase reporter gene system offers a convenient and powerful way of measuring antibodies' in vitro efficacy in triggering ADCC and ADCP.
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The iLite® Fc Effector Activity Bioassays portfolio offers a full range of assay-ready reporter cell lines for the determination of antibody-receptor binding affinity as well as the mechanism of action regarding antibody-dependent, Fc-mediated immune effector function.
By combining cleverly engineered effector cells, that closely resemble the natural Fc signal transduction pathway, with homologous target cells with a controlled antigen expression (+) or depletion (-).
The iLite product portfolio is provided in an “assay-ready” format for a rapid and convenient workflow and a further reduction in assay variability, enabling their use in antibody screening, characterization, stability, and potency studies.
Designing optimal bioassays for measuring ADCC & ADCP activity
Increased interest in therapeutic monoclonal antibody (mAb) development has led to the need for sensitive, reliable, and biologically relevant bioassays for measuring Fc-effector activity. In this application note, Svar Life Science presents the advantages of using iLite Fc-effector activity bioassays for measuring ADCC and ADCP activity in vitro.
Biosimilar development: Experts discuss analytical characterization toolkits for antibody therapeutics
Experts from Xbrane Biopharma discuss the biosimilar development process and how bioassays are the driving force behind reduced cost and accelerated timelines
