Comparison of protein sequencing analysis of CDNF, IL6, and FGF2 on Platinum and mass spectrometry

In this application note, Quantum-Si discusses the challenges associated with traditional mass spectrometry (MS) methods for protein identification, including missed cleavages, chemical modifications, and the differentiation of similar amino acids. These factors often limit the accuracy of peptide mapping in proteomic analysis. Quantum-Si introduces its Platinum^® instrument, which utilizes dye-tagged N-terminal amino acid recognizers and semiconductor chip technology to sequence proteins at the single-molecule level. This innovative approach overcomes the limitations of traditional MS methods by providing a user-friendly benchtop instrument and cloud-based analysis software, allowing researchers to achieve deeper proteomic insights without the need for expensive equipment or specialized expertise.