A guide to analytical approaches for characterizing antibody conjugates
9 Jun 2026This guidebook explores analytical strategies for characterizing antibody conjugates, including antibody-drug conjugates (ADCs) and antibody oligonucleotide conjugates (AOCs). It highlights key chromatography and mass spectrometry techniques — such as hydrophobic interaction chromatography, size-exclusion chromatography, reversed-phase LC, and peptide mapping — to assess critical quality attributes including drug-to-antibody ratio, aggregation, and conjugation sites. The guide also examines emerging workflows for complex bioconjugates, supporting improved development, quality control, and regulatory readiness in biopharmaceutical research.
Resource details:
- Resource type: Guidebook
- Page count: 12 pages
- Read time: 18 mins
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