XBridge Premier Protein SEC Column, 250Å, 2.5 µm, 4.6 x 300 mm

This guidebook explores analytical strategies for characterizing antibody conjugates, including antibody-drug conjugates (ADCs) and antibody oligonucleotide conjugates (AOCs). It highlights key chromatography and mass spectrometry techniques — such as hydrophobic interaction chromatography, size-exclusion chromatography, reversed-phase LC, and peptide mapping — to assess critical quality attributes including drug-to-antibody ratio, aggregation, and conjugation sites. The guide also examines emerging workflows for complex bioconjugates, supporting improved development, quality control, and regulatory readiness in biopharmaceutical research.

Resource details:

• Resource type: Guidebook
• Page count: 12 pages
• Read time: 18 mins