Drug discovery > Target Discovery Products & Reviews

 The BioFlo 320 seamlessly blends beauty and utility in one all-inclusive package. A new industrial design, flexibility between interchangeable autoclavable and single-use vessels, intelligent sensors, Ethernet connectivity, and a new software package are only a few of the features that set it apart from the competition

The Eppendorf BioFlo 120 offers simplicity and ease of use, without sacrificing capability. In academic, governmental or industrial research settings; for work with bacteria, yeast, fungi, mammalian, insect or plant cells: The BioFlo 120 is an attractive solution to meet bioprocessing needs. The BioFlo 120 is a bench-scale bioreactor/fermentor system that perfectly suits research and development. Its flexible design meets t…

Small working volumes save valuable material and medium in process development and screening procedures. The Eppendorf DASbox Mini Bioreactor is a fully instrumented mini bioreactor featuring industry standard design and advanced control functionalities.

Clean Screen® Xcel Well Plates The Clean Screen Xcel products are a line of sample prep phases designed to reduce the number of steps in the extraction, and therefore the amount of time and solvent necessary to complete the sample cleanup. Further advantages include reduced sample size and improved cleanliness and recovery. The Xcel I well plate will extract a wide array of basic drugs including benzodiazepines and opiates.…

Positive Pressure Manifold - A simple, robust way to quickly process up to 48 samples at one time. The Positive Pressure Manifold can accommodate a multitude of column sizes and provides even flow to each position. Positive Pressure Manifold Features: All 48 positions are individually regulated to provide even pressure to each column. There are four banks of 12 positions each. The user can control flow to each of the four…

Our 96 Deep Well Plates are made from solvent resistant, low extractable polypropylene. Standard frits are polyethylene with 20μm pores. The 2mL well provides capability for methods that require a larger sample size. The separate wells and greater capacity eliminate well-to-well carry over. We offer disposable plates compatible with Beckman, Caliper, Gilson, Hamilton, PerkinElmer and Tecan liquid handling systems. 96 Deep Wel…

Abalone derived enzyme. Available in both liquid and lyophilized forms. Liquid enzyme activity > 100,000 Units/mL - Lyophilized enzyme activity 1,000,000 - 3,200,000 Units/g

ultraWAVE has already revolutionized and enhanced the way analytical chemists think to sample preparation for trace metal analysis in hundreds of laboratories all over the world. ultraWAVE is based on the SRC (Single Reaction Chamber technology), invented by Milestone several years ago ( EP0728038B1 ). SRC technology achieves extraordinary performance capabilities combining microwave heating with a high-pressure reactor which…

The process of fat determination in food and feed matrices is a routine analysis still relies on outdated and matrix-dependent methods which use obsolete and time-consuming technologies. The ETHOS X offers a new approach to gravimetric fat determination, moving toward a more modern, greener and more efficient approach to total fat, Fatty Acid Methyl Ester (FAME) and free fat determinations in food and feed matrices.

Microwave-assisted solvent extraction offers superior lab efficiency in the determination of organic pollutants with microwave green extraction technique. Typical applications include chlorinated pesticides, semi-volatile organics, PAHs, PCBs, chlorinated herbicides, phenols, organophosphorus pesticides, dioxins and furans. ETHOS™ X with the fastEX-24 rotor allows the simultaneous extraction of 24 samples in 40 minutes with mi…

The ETHOS™ LEAN collects Milestone experience and embraces all these values into a compact and economical solutions for sample preparation, matching the requirements of laboratories that approach microwave digestion without the needs of high-volume labs.

The features of the new ultraWAVE 3 merge with those already intrinsic in the SRC technology so that labs will experience higher performance, greater productivity, and more streamlined workflow, providing them with improved competitiveness and a lower cost of ownership. Thanks to its superior digestion capabilities that result from its higher temperature and pressure capabilities, ultraWAVE 3 microwave system provides great…

The DPPIV-Glo™ Protease Assay is a homogeneous, luminescent assay that measures dipeptidyl peptidase IV (DPPIV) activity. DPPIV is a serine protease that cleaves N-terminal dipeptides from polypeptides with L-proline or L-alanine at the penultimate position. The DPPIV-Glo™ Assay provides a proluminescent DPPIV substrate, Gly-Pro-aminoluciferin, in a buffer system optimized for DPPIV and luciferase activities. The addition of a…

The ONE-Glo™ Luciferase Assay System provides a highly sensitive, robust, homogeneous assay for detection of firefly luciferase reporter gene expression in mammalian cells. Ideally suited for high- and ultrahigh-throughput applications, the ONE-Glo™ Assay contains a new luciferase substrate, resulting in a reagent that is more stable, more tolerant to sample components, and has less odor than standard luciferase assay reagents…

The ApoTox-Glo™ Triplex Assay combines three assay chemistries to easily assess viability, cytotoxicity and apoptosis events in the same cell-based assay well. First, viability and cytotoxicity are determined by measuring two differential protease biomarkers simultaneously with the addition of a single nonlytic reagent containing two peptide substrates. The live-cell protease activity is restricted to intact viable cells and i…

The Griess Reagent System measures nitrite (NO2–), which is one of two primary stable and nonvolatile breakdown products of nitric oxide (NO). Nitric oxide is an important physiological messenger and effector molecule in many biological systems, including immunological, neuronal and cardiovascular tissues. This assay relies on a diazotization reaction that was originally described by Griess in 1879. Through the years, many mod…

The QuantiFluor™ RNA System contains a fluorescent RNA-binding dye that enables sensitive quantitation of small amounts of RNA in solution. Detecting and quantitating small amounts of RNA is a very important step used in many biological applications, particularly in molecular biology techniques. These include measuring yields of in vitro transcribed RNA and measuring RNA concentrations before performing Northern blot anal…

The ROS-Glo™ H2O2 Assay is a homogeneous, fast and sensitive bioluminescent assay that measures the level of hydrogen peroxide (H2O2), a reactive oxygen species (ROS), directly in cell culture or in defined enzyme reactions.   This assay allows identification of conditions or test compounds, such as small molecule inhibitors or inducers, that alter ROS levels. The scalable multiwell format couples a stable luminescent si…

Trypsin/Lys-C Mix, Mass Spec Grade, is a mixture of Trypsin Gold, Mass Spectrometry Grade, and rLys-C, Mass Spec Grade. The Trypsin/Lys-C Mix is designed to improve digestion of proteins or protein mixtures in solution.   Using the conventional trypsin digestion protocol (i.e., overnight incubation at nondenaturing conditions), Trypsin/Lys-C Mix improves protein digestion by eliminating the majority of missed cleavages,…

Polyclonal secondary antibodies raised in goat, rabbit or donkey, immunoaffinity-purified using corresponding immobilized antigens and conjugated to horseradish peroxidase (HRP) enzyme.   The Anti-Human IgG (H+L), HRP Conjugate, Anti-Mouse IgG (H+L), HRP Conjugate and Anti-Rabbit IgG (H+L), HRP Conjugate antibodies bind to both heavy and light chains for all IgG subclasses. As with all antibodies, in certain applications…

Trypsin is a serine protease that specifically cleaves at the carboxylic side of lysine and arginine residues.   The stringent specificity of trypsin is essential for protein identification. Native trypsin is subject to autolysis, generating pseudotrypsin, which exhibits a broadened specificity including a chymotrypsin-like activity. Such autolysis products, present in a trypsin preparation, would result in addition…

The LigaFast™ Rapid DNA Ligation System is designed for the efficient ligation of sticky-ended DNA inserts into plasmid vectors in just 5 minutes (blunt-ended inserts in as little as 15 minutes).   Rapid ligation is based on the combination of T4 DNA Ligase with a unique 2X Rapid Ligation Buffer to speed up and streamline your cloning experiments. The LigaFast™ System is designed to eliminate any further purification pri…

ViaFect™ Transfection Reagent allows high-efficiency transfection of a wide range of cell types, including iPS Cells, without compromising cell viability.   ViaFect™ Transfection Reagent enables the design of biologically relevant assays in workhorse adherent cell models, suspension cells important for studying cell signaling, and even differentiated cell lines derived from stem cells. ViaFect™ Transfection Reagent offer…

This ready-to-use multimode detection system includes: high-performance luminescence, fluorescence, UV-Visible absorbance, BRET and FRET, two-color filtered luminescence and kinetic measurement capabilities.   The GloMax® Discover System is a high-performance multimode detection instrument developed with Promega reagent chemistries to provide a simple means of detecting advanced chemistries. This instrument provides…

ADP-Glo™ Kinase Assay is a luminescent kinase assay that measures ADP formed from a kinase reaction; ADP is converted into ATP, which is converted into light by Ultra-Glo™ Luciferase.   The luminescent signal positively correlates with kinase activity. The assay is well suited for measuring the effects chemical compounds have on the activity of a broad range of purified kinases, making it ideal for both primary scre…