Drug discovery > Target Discovery Products & Reviews

The NanoBRET™ Target Engagement (TE) Intracellular BET BRD Assay measures compound binding at select BET bromodomain target proteins within intact cells. This target engagement assay is based on the NanoBRET™ System, an energy transfer technique designed to measure molecular proximity in living cells

Single-Use Ligands for High-Resolution lmaging in Live Cells

The RealTime-Glo™ MT Cell Viabiilty Assay measures viability of cells in a non-lytic, real-time live-cell format, saving time, cells and reagent costs.

The Dual-Luciferase® Reporter (DLR™) Assay System(a–f) provides an efficient means of performing two reporter assays. In the DLR™ Assay, the activities of firefly (Photinus pyralis) and Renilla (Renilla reniformis or sea pansy) luciferases are measured sequentially from a single sample. The firefly luciferase reporter is measured first by adding Luciferase Assay Reagent II (LAR II) to generate a luminescent signal lasting at l…

High-throughput quantitation of firefly (Photinus pyralis) luciferase expression in mammalian cells is commonly performed by batch processing of 96- and 384-well plates. Steady-Glo® Luciferase Assay System(a,b,c) is designed for this purpose by providing long-lived luminescence when added to cultured cells. The homogeneous assay provides signal half-lives of over 5 hours in commonly used cell culture media without prior sample…

The CellTiter-Blue® Cell Viability Assay provides a homogeneous, fluorescent method for monitoring cell viability. The assay is based on the ability of living cells to convert a redox dye (resazurin) into a fluorescent end product (resorufin). Nonviable cells rapidly lose metabolic capacity and thus do not generate a fluorescent signal. The homogeneous assay procedure involves adding the single reagent directly to cells cultur…

The Dual-Glo® Luciferase Assay System is a homogeneous reagent system that enables fast and simple quantitation of a stable luminescent signal from two reporter genes in a single sample. This convenient "add-and-read" system generates both firefly and Renilla luciferase luminescence signals from cells that have not been preconditioned or prelysed. With the Dual-Glo® System, internal controls can be established to minimize s…

Use with ADP-Glo™ Assay for bioluminescent detection of kinase activity

The Promega CytoTox 96® Non-Radioactive Cytotoxicity Assay is a colorimetric alternative to radioactive cytotoxicity assays. The CytoTox 96® Assay quantitatively measures lactate dehydrogenase (LDH), a stable cytosolic enzyme that is released upon cell lysis, in much the same way as [51Cr] is released in radioactive assays. Released LDH in culture supernatants is measured with a 30-minute coupled enzymatic assay that result…

Western Blot Incubation Boxes are suitable for incubating near-infrared fluorescent or chemiluminescent Western blots or gels.

The Odyssey® CLx Infrared Imaging System gives you accurate, reproducible quantitative Western blotting results with near-infrared fluorescence.

NewBlot Western Blotting Stripping Buffers conserve precious samples by reusing the same blot and you save money.

Imaging probes conjugated to IRDye 800CW and IRDye 700DX have propelled more than 20 Phase I and Phase II clinical trials worldwide.

The CosMx Spatial Molecular Imager is an FFPE-compatible, single-cell imaging solution that enables researchers to investigate intact tissues through the power of spatial multiomics.

The new Flexus® product line brings you the most flexible, modular, state-of-the-art robotic pipeting system available. Designed to readily adapt to your changing needs its upgradeability ensures it will keep up with today’s ever advancing scientific techniques. The modular design allows the hardware to be configured to suit a very wide range of applications and simplifies both system integration and stand alone robotic automa…

USB Sample Processor with one workstation and one built-in membrane pump for the automatic processing of routine samples in series with small to medium quantities. In addition to the built-in pump, an additional one (membrane or peristaltic) and up to three dosing devices for Liquid Handling tasks can be connected.

Remove the guesswork. SONICC ® finds protein crystals that other technologies cannot. The ultimate imaging technology in visualizing protein crystals, Second Order Nonlinear Imaging of Chiral Crystals (SONICC) definitively finds crystals buried in precipitate or submicron crystals naked to the eye. 

Crystal Clear Imaging. Unparalleled Speed. ROCK IMAGER ® - Crystallization Imagers are a series of automated imaging systems designed for protein crystallization screening. Capture superior quality images of your protein drops while learning critical information about your crystals. ROCK IMAGERs are available with various plate capacities and imaging features, so there is a model to fit every lab's budget and workflow.

Through its exceptional image quality and the widest size range available, FlowCam® 8000 represents state-of-the-art particle imaging technology. Analyze thousands of particles in less than a minute and comprehensively characterize the size, count, morphology, and identity of subvisible and visible particulates in their native solvent.

The Genizer HandExtruder is a cost-effective tool for micro liposome extrusion. Users manually push the syringe plunger to force the sample through a filter membrane, repeating the process 5 to 10 times for consistent liposome sizes.

BellBrook Labs Transcreener ® UDP² Glycosyltransferase Assays

The Vi-CELL Series Cell Viability Analyzers provide an automatic and cost effective means to perform the trypan blue dye exclusion method.

The Biochrom 30+ Amino Acid Analyzer is trusted by hospitals, reference labs, pharmaceutical and industrial labs worldwide. It accurately detects and quantifies amino acids and their derivatives in complex samples. Applications include: detection and monitoring of in-born errors of metabolism, PKU testing, clinical analysis, proteomics, drug synthesis, infusion fluids, and quality control. The system is based on cation exc…

The Finnigan TSQ Quantum Series of mass spectrometers are the most advanced and powerful triple quadrupole mass spectrometers available. The Quantum Series mass spectrometers feature the patented HyperQuad™ mass analyzer technology, a rugged orthogonal source, and a completely redesigned analyzer geometry for maximum sensitivity, precision, and reliability. The Quantum Series triple quads are the only commercial triple quads a…

This advanced, high performance ion trap - Fourier Transform mass spectrometer is the right tool for your toughtest analytical challenges in metabolic studies, proteome analysis, pharmaceutical discovery, and all other applications. Product detail: The Finnigan LTQ FT™ combines the most advanced Ion Trap and Fourier Transform Ion Cyclotron Resonance technologies into a single instrument with unprecedented analytical power…