Drug Discovery & Development Products & Reviews

Integrated IND-enabling development for small molecules, with GMP API and drug product, GLP safety, DMPK and bioanalysis under one roof.

GLP and GCP bioanalysis for small molecules, biologics, oligonucleotides and cell and gene therapies, with LC-MS/MS and ligand binding assays covering method development, validation, immunogenicity and preclinical to Phase IV sample analysis.

End-to-end early clinical development, from first-in-human and proof-of-concept trials to regulatory submissions, biomarker translation, bioanalysis and clinical supply, delivered by one senior team with a single point of contact.

Tailored de-risking for a shortlist of mainly small molecule candidates, assessing API developability, formulation, DMPK and in vitro and in vivo safety to confirm the right clinical candidate before IND-enabling investment.

Integrated biostatistics, clinical data management, CDISC data standardization and PK/PD modeling to turn preclinical and clinical study data into submission-ready, decision-grade results, from early discovery through Phase III.

In vitro toxicity screening in 3D microtissue, spheroid and multilayer cell models of liver, heart, brain and intestine, supporting repeat-dose studies with high content imaging and biochemical endpoints for more human-relevant safety data.

Evidence-based evaluation of the safety risks of modulating a drug target, combining an AI/ML-powered data platform with toxicology expertise to score liabilities, flag on-target toxicities and recommend de-risking assays before costly investment.

High-content Cell Painting assay that images multiple organelles to measure over 1,500 morphological features, delivering concentration-response points of departure to flag compound toxicity and mechanisms of action early in drug discovery.

Global regulatory strategy, FDA and EMA interactions, and IND, CTA and IMPD dossier preparation for small molecules, antibodies, oligonucleotides and cell and gene therapies, integrated into your R&D program from early development onward.

Screening and cardiac safety testing, from automated patch clamp hERG and CiPA ion channel assays to iPSC cardiomyocyte MEA and 3D cardiac microtissues, detecting functional and structural cardiotoxicity early in drug discovery.

YMC HT Glass Columns are specially designed to accommodate the stringent requirements of high-temperature liquid chromatography applications. Capable of performing efficiently at temperatures up to 70 °C, these columns are perfectly suited for a broad spectrum of purification tasks, particularly in biochemical liquid chromatography (BioLC), where high temperatures are pivotal.

From laboratory to pilot scale, YMC offers reliable, high quality glass columns for all kind of application areas.

YMC PilotPLUS columns are completely biocompatible and characterised by safe and easy handling.

Does your application require customised pilot columns? With YMC Pilot columns, customised versions can be constructed to address your needs. Of course standard dimensions are available, too!

Investigate microscopic materials with the Thermo Scientific Nicolet RaptIR X FTIR Microscope, which combines research-grade FTIR microscopy with intuitive workflows and flexible configurations to help users identify materials, characterize microscopic features, and support applications ranging from quality assurance and failure analysis to advanced materials research.

The Thermo Scientific GENESYS G5 family is built on a standardized platform with shared accessories, software, and workflows across all models. This allows laboratories to simplify training, standardize operations, and flexibly adapt instrument configurations as analytical needs evolve.

The Thermo Scientific GENESYS G5 family is built on a standardized platform with shared accessories, software, and workflows across all models. This allows laboratories to simplify training, standardize operations, and flexibly adapt instrument configurations as analytical needs evolve.

NanoDrop Ultra FL integrates both absorbance and fluorescence measurement capabilities on a single pedestal. This model enhances sensitivity for low-concentration samples, detecting down to 0.1 ng/µL dsDNA, and provides a complete analysis solution with advanced contaminant detection and sample integrity alerts.

NanoDrop UltraC FL features pedestal and cuvette absorbance, along with pedestal fluorescence capabilities. It delivers high sensitivity and specificity, optimal for various applications requiring detailed analysis of nucleic acid and protein samples, while ensuring seamless integration with lab workflows and compliance requirements.

NanoDrop UltraC combines pedestal and cuvette absorbance measurements, expanding its versatility for various sample types. It offers high sensitivity and reliability for both concentrated and dilute samples, making it ideal for comprehensive analytical needs in research and production environments.

NanoDrop Ultra is a microvolume UV-Vis spectrophotometer that provides high-accuracy absorbance measurements for DNA, RNA, and proteins. It features advanced software for detecting impurities and differentiating nucleic acids from diverse biological samples, ensuring precise analytical results.

The Thermo Scientific GENESYS G5 family is built on a standardized platform with shared accessories, software, and workflows across all models. This allows laboratories to simplify training, standardize operations, and flexibly adapt instrument configurations as analytical needs evolve.

The DeNovix Squid™ Full Range Pipette is a revolutionary electronic pipette that replaces an entire traditional set with a single, high-performance device. Squid Pipettes are built on accuracy, exceeding ISO 8655 calibration specifications across the entire 1 - 1000 µL range.