Merck Products & Reviews

Safeguard the high quality of our volumetric reagents

Sigma-Aldrich ® one-part sgRNA and two-part crRNA:tracrRNA systems accelerate genome editing with Cas9 protein, mRNA, or established Cas9 expressing cell lines. Our guides are compatible with a variety of delivery methods including microinjection, electroporation, and lipofection.

With the largest portfolio of Cas9 proteins available, Merck make it easy to find the perfect nuclease for your gene editing experiment.

Merck's immuno-oncology cell lines are innovative research tools for biologics discovery and clinical development. These are the perfect cell-based assay tools you need for the entire drug discovery and clinical development process. Whether you need screening tools for CAR/TCR therapies and mAB development, target cells for efficacy testing, or potency assays for clinical development, Merck provides functional biologically-re…

The largest and most validated shRNA collection from the RNAi consortium (TRC). Merck's unique shRNA formats leverage the discovery potential of the trusted and proven TRC shRNA collection. When you partner with them, you gain access to their world class lentiviral production expertise and the formats and specifications for RNAi knockdown experiments at any scale.

A comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients.

Nuclease-independent applications of CRISPR provide equal targeting specificity but instead of cutting, CRISPRi allows for targeted interference of gene function by delivering transcriptional repressor domains to a specific target sequence using modified dCas9 + gRNA complexes. Gene knockdown is complementary to CRISPR-KO and CRISPRa (activation) and has distinct advantages over existing loss-of-function strategies like RNAi.…

Patient-derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology.

MS β-glucuronidase is a prebuffered, bench-stable, and automation-ready hydrolysis mix for urine drug testing workflows. Discover how to leverage its reduced hands-on time and improved stability. 

The next generation of RNP reagents

SeQuant ® HILIC (hydrophilic interaction liquid chromatography) HPLC columns carry densely bonded, zwitterionic functional groups. These columns are available in a variety of lengths, particle sizes, and pore dimensions while showing an exceptional reproducibility and robustness.

Chromolith ®  columns have shown great potential and superiority in comparison to standard silica. In contrast to conventional, packed-particle columns, wide pore (300 Å) monolithic silica columns are made of a single continuous-bed rod of high purity porous silica that is then bonded with C18, C8, C4, Epoxy, and Protein A depending on the use of the column.

Accurate Photometric analysis for Water, Environmental, Food and Beverage Testing

The T7 Endonuclease Detection Assay is a well-known method for detecting genome editing events from CRISPR, Zinc-finger nuclease, and TALEN gene targeting. Originally identified from Escherichia coli bacteriophage, the T7 endonuclease can cleave mismatched heteroduplex DNA, Holliday junctions, branched DNA, and cruciform DNA.

All-in-one, ready-to-use Cas9 and guide RNA (gRNA) expression plasmids for use with monocots and dicots.

Spectroquant ® tests and kits for accurate, precise and consistent results

CRISPR/Cas9-mediated recombineering is the most powerful bacterial genome engineering method to date. In addition, Cas9-mediated recombineering overcomes the dependence on a second recombination step, avoids the creation of destabilizing scar sites, can be used in multiplexing, and is less time-consuming than previous protocols.

This Lentiviral Packaging Mix is an optimized formulation of two plasmids expressing the key HIV packaging genes and a heterologous viral envelope gene.

Universal negative control CRISPRs have been designed not to recognize any sequence in the human, mouse or rat genome. 

Compare and contrast the features of a wide variety of guide RNA (gRNA) and Cas9 products for in vitro and in vivo CRISPR experiments. Select the best formats for your mammalian or plant applications: SygRNA ® synthetic gRNA, plasmid DNA, lentiviral particles, and proteins.

An easy-to-use, modular platform to co-culture different cell types in discrete 3D and 2D compartments.

Exclusive human or mouse whole genome arrayed libraries developed with the Wellcome Sanger institute

Pooled CRISPR screening with 10x Genomics compatibility

Easier nucleic acid preparation with fewer impurities.

Easier nucleic acid preparation with fewer impurities.