3dGRO™ Human Lung Organoid Culture System
The 3dGRO™ Human Lung Organoid Culture System is a multi-stage culture system for efficient differentiation of human induced pluripotent stem (iPS) cells to mature lung organoids.
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
Lung organoids are 3D cell culture models that possess a complex tissue architecture that more closely resembles in vivo tissues and can be used for studying human lung development and respiratory diseases including viral infections (SARS-CoV, H1N1, MERS), cystic fibrosis, asthma, COPD, and the effects of air pollution and smoking.
The 3dGRO™ Human Lung Organoid Culture System is a serum-free, multi-stage culture system for efficient differentiation of human induced pluripotent stem (iPS) cells to mature lung organoids. Using the 3dGRO™ Human Lung Organoid Culture System, large numbers of mature lung organoids can be generated that express markers found in the mature lung and airways including SFTPB and SFTPC (surfactant protein B and surfactant protein C), MUC5AC, EpCAM, Sox9 and Nkx2.1, acetyl-α-tubulin, and vimentin. Additionally, lung organoids express angiotensin-converting enzyme 2 (ACE2), the receptor for the novel SARS-CoV-2 virus that causes COVID-19, along with TMPRSS2, the serine protease that enhances SARS-CoV-2 viral entry.
Patient-derived organoid (PDO) gastrointestinal biobank
Patient-derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology, thus representing a clinically relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models.
In this free download, explore Merck’s comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids from both normal and diseased patients derived from multiple regions of the digestive systems including small intestine (duodenum, ileum), stomach, rectum and colon.
MilliporeSigma is the Life Science business of Merck KGaA, Darmstadt, Germany in the USA and Canada.
3dGRO™ organoids were derived utilizing HUB Organoid Technology.
