GL Sciences, Inc. Products & Reviews

Inertsil ODS columns are general-purpose reversed phase C18 columns, available in 5-µm and 10-µm particle sizes. It was the first of the ODS columns from GL Sciences, introduced back in 1986. We currently recommend InertSustain C18 or Inertsil ODS-4 columns for all new method developments.

Silica-based columns are stable and efficient but unsuitable for alkaline analyses due to the silica matrix's weakness under high pH. InertSustain C18, with its novel surface-modified silica, overcomes this limitation. It retains Inertsil's benefits—low back pressure, superior inertness, high efficiency, consistent performance, and wide solvent compatibility—while enabling analyses over a broad pH range.

The MonoSpin series is a spin column optimized for rapid preparation of biological samples like blood, serum, and urine. Using silica monoliths, it enables fast separation and high sensitivity. SPE is completed within 10 minutes by centrifugation. Available in Spin, Large, and 96-well formats, it offers high recovery without frits and is ideal for peptides, proteins, drugs, glycans, and organic acids.

The FM4 Air Sampler is the world's first portable device for simultaneous collection and analysis of particle and gas-phase PFAS in air. It uses an impactor and three collectors, including the newly developed GAIAC adsorbent, which enables efficient collection and elution of gas-phase PFAS. PFAS can be analyzed by GC-MS/MS and LC-MS/MS after solvent elution.

The InertCap 5MS/EX GC Capillary Column combines GL Sciences’ 50+ years of GC expertise with advanced arylene and proprietary deactivation technologies. Offering ultra-low bleed, high inertness, and superior separation, it stands as the most versatile slightly polar column for GC-MS. From food safety and environmental testing to pharmaceuticals and forensics, it ensures reliable and high-sensitivity results.

The TB-PLOT Series GC PLOT Columns feature a strongly immobilized porous layer, offering unmatched separation, excellent reproducibility, and superior durability. With a full lineup including Alumina (KCl, S, M), MoleSieve 5A, Q, U, GasPro, and Oxy, these columns provide optimal solutions for hydrocarbons, fixed gases, oxygenates, and impurity analysis without the need for trap columns.

MonoSpin Pro Series packs monolithic silica into spin columns and 96-well plates for ultrafast antibody prep. No frits, minimal dead volume. Complete in <10 min at ~2,300×g and elute in just 100 μL with ≥90% IgG recovery (ProA)—competitors often need ≥400 μL for ~65–70%. Choose ProA/ProG for Fc capture or ProL for Fab selectivity; formats include Type S, 96-well, and Large (up to 8 mL).

The SP209 Series Air Sampling Pump offers dual sampling in a single unit. With two independent lines, each with its own flow control, it allows precise, simultaneous sampling at different flow rates. Compact and portable, the SP209 is ideal for environmental monitoring, indoor air studies, and VIAQ testing.

EPA Method 1633 efficiently determines PFAS in complex samples. InertSep, a line of solid-phase extraction cartridges, is known for high purity, consistency, and quality. InertSep WAX FF and GCB offer high recovery rates and cleanup efficiencies for PFAS in water, soil, food, and other complex matrices. InertSep GCB, packed with Graphite Carbon Black, is ideal for LC/MS analysis due to its excellent cleanup efficiency.

InertSep QuEChERS Kit is a product developed by leveraging decades of expertise in manufacturing high-quality chromatography products. This kit efficiently removes impurities such as organic acids, sugars, fatty acids, pigments, chlorophyll, and carotenoids from samples, enhancing the accuracy and reliability of subsequent analyses using LC/MS or GC/MS.

Inertsil Hybrid-C18 is a high-pH resistant HPLC column that enables stable and reproducible separations across a wide pH range (1–12). Built with hybrid silica technology, it ensures excellent peak shapes even for basic analytes and provides superior lifetime compared to conventional C18 columns. Available in 1.7 µm, 3.5 µm, and 5 µm, it is ideal for LC-MS and method development.

GL Sciences' Bio LC Columns "ProteoSil" are tailored HPLC solutions designed specifically for proteomics and the analysis of bio molecules such as proteins, peptides, and nucleic acids. The packing materials used in these columns are crafted from high-purity silica, offering pore sizes of 100Å, 200Å, and 300Å. They are available in multiple configurations, including reversed phase, HILIC, and size exclusion columns.

InertSep Oligo is a solid-phase extraction (SPE) product for oligonucleotide purification in LC/MS workflows. It delivers high recovery, low variability, and full LC/MS compatibility. Formats include 96-well plates—Micro Elution (2 mg/400 µL) and 2 mL square-well (25 mg)—and straight barrel cartridges in multiple sizes for manual or automated high-throughput sample prep.

Meet the InertSep Micro Elution SPE Plate: elongated wells and a high-efficiency 2 mg sorbent bed drive strong retention with just 25–150 µL elution. Skip dry-down, use less solvent, and accelerate LC–MS/MS workflows. Handle 10–100 µL samples with excellent recovery across HLB, MCX/WCX, and MAX/WAX chemistries.