Agilent Technologies Drug discovery > Lead Discovery Products & Reviews

Agilent Bio SEC-5 HPLC columns are packed with 5 µm silica particles coated with a proprietary, neutral, hydrophilic layer for maximum efficiency and stability. Our specially designed packing also promotes high pore volume, improving both peak capacity and resolution. 

Method validation is a critical step for biotherapeutic drug development. It ensures that the analytical method is suitable for its intended purpose, and that it meets regulatory requirements.

Agilent ZORBAX GF-250 and GF-450 size exclusion (gel filtration) columns are for size separations of proteins and other biomolecules. The separation range is 4,000-900,000 for globular proteins when using GF-250 and GF-450 columns in series.

Agilent AdvanceBio MS Spent Media columns are HILIC columns that deliver fast, sensitive, and reproducible separations of underivatized amino acids and other polar metabolites found in bioprocessor cell culture media for mass spectrometric detection.

Agilent Bio Ion-Exchange HPLC columns are packed with polymeric, nonporous, ion-exchange particles. Bio Ion-Exchange Columns are designed for high resolution, high recovery and highly efficient separations of peptides, oligonucleotides and proteins.

Thorough characterization of monoclonal antibodies includes the identification and monitoring of acidic and basic isoforms. The Agilent Bio MAb HPLC columns feature a unique resin specifically designed for high-resolution charge-based separations of monoclonal antibodies.

PL-SAX for Biomolecules is ideal for the anion-exchange HPLC separations of proteins and deprotected synthetic oligonucleotides under denaturing conditions.

PL-SCX is a macroporous PS/DVB matrix with a very hydrophilic coating and strong cation-exchange functionality. 

ZORBAX Ion Exchange columns are available as both Strong Anion-Exchange (SAX) and Strong Cation-Exchange (300SCX) columns. 

Agilent 2-AA (formerly ProZyme) labeled N-glycan standards and libraries are commonly used as qualitative standards for LC/FLD and LC/MS. 

Agilent 2-AB (formerly ProZyme) labeled N-glycan standards and libraries are commonly used as qualitative standards for LC/FLD and LC/MS. 

Agilent 2-AB (formerly ProZyme) labeled O-glycan standards are commonly used as qualitative standards for LC/FLD and LC/MS.

Agilent APTS (formerly ProZyme) labeled glycan standards are commonly used for qualitative N-glycan identification or as migration standards for capillary electrophoresis with laser-induced fluorescence (CE/LIF).

Agilent Blood Group Oligosaccharides (formerly ProZyme) standards are offered as disaccharide and trisaccharide forms.

Agilent Glycan Alignment (formerly ProZyme) Standard Set includes the Gly-Q glucose unit (GU) ladder and Gly-Q migration standards.

Agilent N-glycan standards (formerly ProZyme) and libraries are used in many analytical procedures including LC/FLD, LC/MS, and CE/LIF.

Agilent InstantAB (formerly ProZyme) labeled N-glycan standards and libraries are commonly used as qualitative standards for LC/FLD and LC/MS.

Agilent InstantPC (formerly ProZyme) labeled glycan standards and libraries are commonly used as qualitative standards for LC/FLD and LC/MS. 

Agilent InstantQ (formerly ProZyme) labeled N-glycan standards and libraries are used as qualitative standards for the Gly-Q CE system.

Agilent Lewis Antigen (formerly ProZyme) standards are available in labeled and unlabeled forms.

Agilent unlabeled N-glycan (formerly ProZyme) standards are used as qualitative standards for LC/FLD, LC/MS, or CE/LIF.

AdvanceBio Desalting-RP cartridge-style columns can be used on any LC system for on-line desalting of collected fractions. They can also be used on an Agilent 1290 Infinity II 2D-LC system as the second dimension to desalt after the first-dimension separation.

Agilent AdvanceBio RP-mAb columns are designed to optimize the performance of intact and reduced mAb analysis when analyzing monoclonal antibodies for biopharma discovery, development, and QA/QC applications

PLRP-S for Biomolecules products are available in a range of pore sizes and particle sizes, all with identical chemistry and fundamental adsorptive characteristics. The particles are inherently hydrophobic so there is no bonded phase, alkyl ligand required for reversed-phase separations.

Agilent ZORBAX 300Å StableBond columns are an ideal choice for the reproducible separations of proteins and peptides.