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Y-27632 by STEMCELL Technologies Inc.

Manufacturer STEMCELL Technologies Inc.  |   Model: 72302
5.0
/
5.0
  |  1 reviews
RHO/ROCK pathway inhibitor; Inhibits ROCK1 and ROCK2
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Y-27632 by STEMCELL Technologies Inc. product image
Y-27632 (Dihydrochloride)

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Average Rating: 5.0
1 Scientist has reviewed this product

5 out of 5
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money


  • Status:

    Reviewer
  • Member since: 2023

  • Organization: Entrada Therapeutics



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Consistent user for the last 6 years - can't go wrong with this supplier!
Rating: 5.0

  • Application Area: Inhibit cell death of stem cells derivatives when plating from frozen stocks for terminal differenti

"Easy to dissolve in DMSO, consistency in molarity and efficacy."

Review date: 31 Oct 2023 | Y-27632

Y-27632 is a cell-permeable, highly potent and selective inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK). Y-27632 inhibits both ROCK1 (Ki = 220 nM) and ROCK2 (Ki = 300 nM) by competing with ATP for binding to the catalytic site. (Davies et al., Ishizaki et al.)

REPROGRAMMING

  • Direct lineage reprogramming of fibroblasts to mature neurons, in combination with CHIR99021, RepSox, Forskolin, SP600125, Gö6983 and Valproic Acid (Hu et al.).

MAINTENANCE AND SELF-RENEWAL

  • Enhances survival of human embryonic stem (ES) cells when they are dissociated to single cells by preventing dissociation-induced apoptosis (anoikis), thus increasing their cloning efficiency (Watanabe et al.).
  • Improves embryoid body formation using forced-aggregation protocols (Ungrin et al.).
  • Increases the survival of cryopreserved single human ES cells after thawing (Li et al.).
  • Blocks apoptosis of mouse ES-derived neural precursors after dissociation and transplantation (Koyanagi et al.).

DIFFERENTIATION:

  • Improves survival of human ES cell monolayers at the initiation of differentiation protocols (Rezania et al.)

Product Overview

Y-27632 by STEMCELL Technologies Inc. product image

Y-27632

Manufacturer STEMCELL Technologies Inc.

5.0 / 5.0 | 1 reviews