XSelect HSS and CSH XP Columns by Waters

Manufacturer Waters
4.5
/
5.0
  |  37 reviews
UHPLC columns for unmatched selectivity choice


XSelect HSS and CSH XP Columns by Waters product image
XSelect HSS and CSH XP Columns
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Average Rating: 4.5
37 Scientists have reviewed this product

5 out of 5
Ease of use
4 out of 5
After sales service
4 out of 5
Value for money


  • Status:

    Reviewer
  • Member since: 2018

  • Organization: R &I



  • Ease of use
    3 out of 5
    After sales service
    3 out of 5
    Value for money
    3 out of 5
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Robust product, with high capacity of use.
Rating: 3.0

  • Application Area: Chemical intermediate

"Robust product, with high capacity of use. Added value for complex matrix analysis."

Review date: 18 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University of undee



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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Great, reliable product.
Rating: 4.3

  • Application Area:Reaction Monitoring

"The columns give us great separation and, with our daily and weekly maintenance, they can last up to a year. In a standard year, we do thousands of injections."

Review date: 15 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Universidad de La Laguna



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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These columns are the best for the quality of my results
Rating: 5.0

  • Application Area:Pharmaceutical Technology

"These columns are easy to use and to clean. They were the best chance for my samples."

Review date: 11 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: AGQ Labs



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Very happy with the results obtained
Rating: 5.0

  • Application Area:Environmental analysis

"Your products have an unbeatable quality."

Review date: 09 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Tetragenx Inc



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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Great resolution and short retention times
Rating: 4.0

  • Application Area:Pharmaceutical products QC analysis

"The column is good for what we were using it for. Short retention times with a nice resolution. Good for routine analysis and development."

Review date: 09 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Sanofi Deutschland GmbH



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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Good product, can use for UPLC and HPLC
Rating: 4.7

  • Application Area:Analyze peptides

"After thousand injection, the column isn't very good."

Review date: 08 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Siegfried Evionnaz SA



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    3 out of 5
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A bit stressed when using these columns.
Rating: 3.3

  • Application Area:Impurities in pharmaceutical compounds (API or intermediates)

"We have had some problems with these columns. Some new one have to be flushed for several hours to have proper results."

Review date: 08 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: HUSLAB



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Long life-time!
Rating: 5.0

  • Application Area:Serotonin metabolite in serum samples

"The columns are stable and robust with very long life-time, our experience over 6000 runs, provides good value for money."

Review date: 08 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Pfizer



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great column, same results as smaller particle size
Rating: 5.0

  • Application Area:Chemical small molecule analysis

"Great separation, with low back pressure at high flow rates on UPLCMS"

Review date: 06 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Zietis Inc



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Excellent and very easy to use
Rating: 5.0

  • Application Area:I use these columns for HPLC and LCMS

"XSelect columns performance are great and worked very well where other columns are failed"

Review date: 05 Oct 2018 | XSelect HSS and CSH XP Columns


  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University of Pennsylvania



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Nice product.
Rating: 5.0

  • Application Area:Metabolomics

"This product is indispensable in our area of work. The product is easy to use and post-sales assistance is great as well along with simple steps for care for the product."

Review date: 05 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: LUNARIA, spol. s r.o.



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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Good results!
Rating: 4.7

  • Application Area:R&D and analytical chemistry

"The column fulfilled our expectation. selectivity, retention, sample throughput, operational stability, excellent peak shape."

Review date: 05 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Nexgen Pharma



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Very Robust Column.
Rating: 5.0

  • Application Area:Vitamin Analysis in Liquid Multivitamin Product

"This column was purchased to replicate a Waters application note. It performed very well, especially under difficult matrix conditions, however ultimately the method was not selected for further development."

Review date: 05 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: PPG Coatings



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    3 out of 5
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Effective results for the application we use the column for.
Rating: 3.3

  • Application Area:Indoor air quality samples

"The select HSS C18 column we have is dedicated for the analysis of DNPH complexes. Sometimes there's coelution with unknown species which we process by using Gaussian skim in our processing method."

Review date: 05 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Istituto Zooprofilattico Sperimentale del Piemonte



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Good results
Rating: 5.0

  • Application Area:Analyze cereulide in food

"Reproducible results, good shape peaks, long column lifetimes"

Review date: 05 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: ANSES



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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A robust column which allows good quality and reproducibility of the results.
Rating: 5.0

  • Application Area:Analysis of pesticides and metabolites in water samples

"A method was developed on XSelect HSS T3 to analyze pesticides and their metabolites in water and sediment. This column allows the separation of 110 compounds of varied chemical families (including polar compounds), in a run time of 13 minutes. The method was validated according to the NF T90-210 standard, which provides specific statistical tools for the evaluation of quantitative methods in the field of water physico-chemical analysis. This underlines the quality and the reproducibility of the results. The choice of this column was made following his trial for a few months. This was possible thanks to the good exchanges that we have with Waters’ salesmen. We also had access to application note and had the ability to contact an application engineer during our development. The same column is currently used for 2 years now, with a quantity of about 200 samples per month. Pre-column is present and is easily replaced every 6 months approximately. This underlines the value for money of this product."

Review date: 05 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Q&Q Labs AB



  • Ease of use
    3 out of 5
    After sales service
    3 out of 5
    Value for money
    4 out of 5
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A quite useful column material with good characteristics.
Rating: 3.3

  • Application Area:Analyze polar compounds

"A quite useful column material with good characteristics."

Review date: 05 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Biohorma BV



  • Ease of use
    5 out of 5
    After sales service
    2 out of 5
    Value for money
    4 out of 5
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Great column!
Rating: 3.7

  • Application Area:Analyze glucosides in herbal extracts

"Column is easy to use, results are reproducible and life-time is long."

Review date: 05 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Takeda



  • Ease of use
    5 out of 5
    After sales service
    3 out of 5
    Value for money
    3 out of 5
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Great performance
Rating: 3.7

  • Application Area:Peptide or small molecule biomarker quantitation

"The Waters XSelect XP column helped me when developing LC-MS methods for hydrophilic compounds, such as peptides or small molecular biomarkers. It worked great and you can use the column in 100% a.q. condition. I love this product."

Review date: 04 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Alcami Corporation



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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Good columns for peptide mapping
Rating: 4.0

  • Application Area:Peptide mapping

"Columns provide good separation of peptides using a variety of mobile phase modifiers."

Review date: 04 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University of Barcelona



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great LC-MS results
Rating: 5.0

  • Application Area:Pharmaceuticals and metabolites

"This column has provided amazing and very reproducible results when coupling HPLC to MS. Great peak shapes and no retention time drifts after long batches of analysis."

Review date: 04 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: DMPK,Medivir AB, Huddinge Sweden



  • Ease of use
    3 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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HSS T3 columns are of great interest
Rating: 4.0

  • Application Area:Analysis of extremely polar nucleoside phosphates in blood, plasma, tissues

"Waters XSelect HSS T3 2.5 µM, UPLC Acquity HSS T3 are used for analyzing extremely polar compounds, such as nucleoside phosphates. Investigation of how well these columns perform is ongoing, i.e if compound sticks to stainless steel. All information regarding chromatography of polar compounds is of interest."

Review date: 04 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Cambrex



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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I like to use Waters products as my first choice
Rating: 4.3

  • Application Area:HPLC Analysis

"Yes, Waters is committed for excellency with application and cost effectiveness."

Review date: 04 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: OncoArendi Therapeutics SA



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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It is one of our main collumns right now.
Rating: 5.0

  • Application Area:Analyze main product and its impurities.

"Basically XSelect saved my job. I couldn't separate main products of its impurities but with Xselect I have managed to do it. Peaks are sharp and well separated."

Review date: 04 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Institute Of Heavy Organic Synthesis



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great results.
Rating: 5.0

  • Application Area:Pesticide analysis

"The column is very fast and selective. After sales service is great."

Review date: 04 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Q&Q Labs



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Very frequently used column. First choice for polar compounds.
Rating: 5.0

  • Application Area:Analyze drugs (small and peptides) in plasma, serum and tissue

"Column has high reproducibility after many injections. Good resolution and some unique qualities. XSelect HSS is first choice for polar compounds. CSH XP Columns were used for a peptide that was hard to get nice chromatographic properties (lots of tailing due to basic properties). CSH XP Columns solved the problem."

Review date: 04 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: sciegen



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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Good and useful
Rating: 4.0

  • Application Area:in hplc analysis

"XSelect HSS columns and XSelect CSH columns are used for HPLC instrument assay and RC analysis in different products results comparison"

Review date: 03 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: CRL



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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Great results and robust
Rating: 4.3

  • Application Area:Metabolites in Plasma

"I got higher quality results and the column is pretty robust. Would recommend to others as well. Ended up buying few CSH columns for the rest of the study"

Review date: 03 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Janssen Pharmaceuticals R&D



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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High standard, top quality column that is also easy to use and lasts long!
Rating: 5.0

  • Application Area:Analytical method development, method validation

"I've used many types of columns from different manufacturers but Waters columns are definitely one of the top quality ones. XSelect C18 column demonstrated a high standard of efficiency, resolution and repeatable results. I particularly like the guard column that goes with it, they have matching guard column for almost all of the columns they offer, the guard column holder is easy to use and provides seamless protection. I recently used the XSelect C18 column to separate and retain polar compounds and it worked perfectly as this column can be used in wider pH ranges for polar method development. If I have options in selecting columns I would go for Waters! You can't go wrong a with high quality column that you can always trust. Their supporting team is also amazing, they provide great resources in literature as well as technical support!"

Review date: 03 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Oregon State University



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Amazing product. We will continue to use it.
Rating: 5.0

  • Application Area:Analyze PAH metabolites in water samples

"The XSelect has been very effective in proper chromatographic separation of OHPAHs."

Review date: 03 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2013

  • Organization: Sigmapharm Laboratories LLC



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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excellent column
Rating: 5.0

  • Application Area:analyze impurities samples

"An excellent column, high quality, produces reproducible results and better resolution can be achieved."

Review date: 02 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Hovione



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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A rugged column for your difficult separations
Rating: 4.7

  • Application Area:Small molecule pharmaceuticals

"XSelect HSS and CSH XP Columns helped us develop challenging methods for multiple different projects. Some of the columns that we purchased some time ago (about three/four years ago) are still in routine use and still have the same separation capabilities when they were brand new."

Review date: 02 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Rhodes Technologies



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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Consistent, easy to Use, affordable column.
Rating: 4.7

  • Application Area:Large Molecule API

"Great customer care and range of products to select from. Consistent results achieved between lots of columns, must have for validation of methods. Overall great experience and we will continue to purchase Waters columns."

Review date: 02 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: GlaxoSmithKline/Sodexo



  • Ease of use
    3 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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Great instrument.
Rating: 4.0

  • Application Area:Product release

"Great application, very easy to use, outcome analysis was great."

Review date: 02 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: CMIC



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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First choice for method development
Rating: 5.0

  • Application Area:Small molecule analysis

"HSS T3 column is my first choice for method development. This columns are pretty tough, I can even start my gradient with 100% aqueous to retain polar analytes during reverse phase chromatography (instead of dealing with HILIC), and get reliable and reproducible quantitation data. Broad pH range, long life, different particle size - great product."

Review date: 02 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Moses Lake Industries



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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Excellent resolution and reproducibility.
Rating: 4.3

  • Application Area:HPLC Method Development

"The XSelect XP series of columns is definitely what you are looking for when seeking sharp peaks and great resolution with small particle size. The information provided with the column is easy to understand and utilize for best performance and the Waters staff is always willing to help in any way possible. I always have a few of these on hand and have developed multiple methods utilizing them!"

Review date: 01 Oct 2018 | XSelect HSS and CSH XP Columns
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Forensic Fluids Laboratories



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Long lasting with great chromatography for use in THC
Rating: 5.0

  • Application Area:THC in oral fluid

"These columns last a very long time and have great chromatography and adequate separation."

Review date: 01 Oct 2018 | XSelect HSS and CSH XP Columns

XSelect eXtended Perfomance (XP) Columns provide the most diverse selection of sorbents for ultra-high performance (UHPLC) separations. The HSS (High-Strength Silica) and CSH (Charged-Surface Hybrid) base particles provide separation scientists with uniquely selective columns that deliver operational stability and method scalability for UPLC, UHPLC and HPLC separation platforms.

Diverse Retention Characteristics

Method development scientists use selectivity and retentivity to influence chromatographic behavior.  The selection of phases in the XSelect family offers the ability to achieve selectivity and retention of a wide variety of compounds without compromising performance attributes such as superior peak shape for basic compounds, low column bleed, excellent batch-to-batch reproducibility or high efficiency.

Maximum Column Performance

When used on low dispersion UHPLC instrumentation, XSelect eXtended Perfomance (XP) columns improve system performance by decreasing peak width and increasing peak height with the result of maximizing analyte sensitivity. All XSelect HSS and XSelect CSH XP columns are designed to be stable at high operational backpressures to allow faster flow rates to accelerate sample throughput.

VanGuard Column Protection

The often complex sample matrices encountered in pharmaceutical, natural product, environmental, and industrial chemical analysis prematurely shorten analytical column lifetime and degrade chromatographic performance. Waters VanGuard Cartridge Columns help improve analytical column performance by removing particulate and chemical contamination that may be present in the mobile-phase stream—without compromising chromatographic performance.

Product Overview

XSelect HSS and CSH XP Columns by Waters product image

XSelect HSS and CSH XP Columns

Manufacturer Waters

4.5 / 5.0 | 37 reviews