WAVEsystem - Bioanalytical System
Keeping kinetics real: label-free data like you've never seen before
WAVEdelta
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Simple to use, no clog, great results
Analyze protein-protein and protein-small molecule interactions
As part of looking for new devices to complement our ITC we tested out the Wave system with the experts at Creoptix. They were particular helpful in training and within 1-2 days we were self sufficient in running kinetics on the system. The data we obtained was phenomenal. We could for the first time measure interactions that have never been shown and other way. Sensitivity was extraordinary, we could get confident, low-noise data from a 500 Da vs 90 kDa protein system. We could also analyze easily a 45 kDa vs 45 kDa PPI system. Thanks to the data quality, ease of use and technical support we decided to upgrade to the WAVEdelta after.
Review Date: 22 Jun 2022 | Malvern Panalytical
Great device for kinetic analyses - We will buy more of them
Small molecule drug discovery, Fragment based drug discovery
The GCI is an very nice tool supporting our biophysical tool set for drug discovery with accurate kinetics. The device is able to detect even fastest kinetics and is very accurate. The waveRAPID mode allows screening of large sets of compounds / fragments by kinetics, which is very helpful. The use of the device is very easy, comfortable and intuitive. Protocols from orthogonal kinetic methods can be easily transferred (and vice versa), which allows fast adoption and optimization of the technical setup. The support of Creoptix is awesome.: they are super reactive and answer the questions detailed. We are super happy with the device and the Creoptix team.
Review Date: 24 Jun 2021 | Malvern Panalytical
Highly recommended!
Small molecule binding kinetics
Very easy to use, produces reliable and reproducible data using a different analysis methods.
Review Date: 18 Jun 2021 | Malvern Panalytical
Great results after optimization. High reproducibility and sensitivity.
Binding screen and kinetics analysis for biomolecular interactions
Very efficient system, significantly accurate data with high reproducibility and sensitivity. Great customer support.
Review Date: 8 Jun 2021 | Malvern Panalytical
High quality data and excellent support.
Small molecule binding, polyphenol-protein interaction, molecular biophysics
This is the best instrument we have come across for label-free small molecule research. The leading sensitivity of grating coupled interferometry, the referencing ability, and carefully designed robotic sample handling make this instrument highly valuable in our lab. What is definitely strong is the excellent support. They really dig deep and take care of even small details in supporting our assay design and later data analysis. Feedback was always fast and very helpful.
Review Date: 17 Nov 2019 | Malvern Panalytical
The Creoptix WAVEsystem, with 4-parallel channels, allows you to confidently detect and quantify biological interactions in real-time, providing both binding affinity and kinetics. Engineered around the sensitive Grating-Coupled Interferometry (GCI) technology and equipped with no-clog microfluidics, the WAVEsystem delivers high-quality kinetic data across a broader range of samples than traditional SPR equipment.
The Creoptix WAVEsystem is equipped with a temperature-controlled autosampler, designed to hold two (2) 48-vial trails, two (2) 96-well plates, two (2) 384- well plates or a combination thereof. With the WAVEcontrol software, every step from assay setup over data evaluation to report writing is simplified with an intuitive design that mirrors the way you work.
Highlights:
- Reliable kinetics below 1 pg/mm2
- Ultra-fast transition times (approx. 150 ms)
- Reliable determination of off-rates up to 10/sec
- Compatible with even the toughest samples
Benefits:
- All sizes welcome. Screen, rank and characterize small analytes and fragments, including weak binders with fast dissociation rates (koff as high as 10/sec).
- Kinetic profiling closer to real life. Assess drug performance in undiluted human blood serum and plasma samples.
- Broadest kinetic range. Quantify binding affinities (Kd) from low pM to high uM with confident kinetic analysis.
- More than buffer. Explore more solubilization and purification conditions for membrane proteins, including viscous detergents, less common solvents, and different additives.
- No clogging, regardless of the size. Analyze and characterize larger molecules (VLPs, liposomes) and aggregates (fibrils) without clogging-risk.
- Tight binders welcome. Measure kinetics of high-affinity binders at low pM affinity (Kd) values.
Applications:
- Screening: off-rate, primary, fragment-based, small molecule campaigns.
- Ligand interaction to membrane protein studies.
- Pharmacology: kinetics in biofluids (blood serum, plasma) for drug potency assessment.
- Biologics: characterization and quantification of antibodies at low limits of detection in biofluids or media.
