Multidrop™ Pico™ 1 and Pico™ 8 Digital Dispenser
Simplify assay set up while saving on compounds, reagents and time with the new Thermo Scientific™ Multidrop™ Pico™ 1 and Pico™ 8 Digital Dispensers
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Drug discovery
Easy to use with single use disposable cassette. Was able to scale down drug dose response testing with minimal use of precious samples and expensive reagents and drugs. Although expensive, the cost of running these tests in standard volumes would have been even more costly.
Review Date: 30 Nov 2021 | Thermo Fisher Scientific
The new Thermo Scientific™ Multidrop™ Pico™ 1 and Pico™ 8 Digital Dispensers offer precise dispensing with volumes between 11pL and 10µL. With it’s easy to use PicoIT software and ability to dispense drug compounds researchers can quickly and easily create drug dose response and drug synergy experiments (combine this functionality with the Thermo Scientific™ Multidrop™ Combi’s cell dispensing capability for a more complete drug synergy dispensing solution). In other applications, miniaturize qPCR reaction volumes, using ten times less sample and reagent than traditional methods, as low as 11pL or eliminate the manual task of serial dilution and improve accuracy and precision while saving reagent costs.
The digital dispenser supports a wide range of applications and sample-types:
- Drug combination studies
- qPCR
- DMPK
- Assay development
- Biochemical assays
- Secondary screening
- Cell-based assays
- Spotting
- Enzyme profiling
- Synthetic biology
- Antibody therapies
Improved Efficiency and Speed
The digital dispenser offers 40 times greater speed than analog serial dilution – from 10 minutes to just 15 seconds – eliminating precious time and accelerating your research.
The digital dispenser offers 40 times greater speed than analog serial dilution – from 10 minutes to just 15 seconds – eliminating precious time and accelerating your research.
Enabling drug synergy and drug dose response assays
Developing assays to assess the effectiveness of drug combinations or different doses of single drugs in vitro is an increasingly important area of drug and anticancer therapy research. In developing high throughput assays, researchers face the double challenge of quickly dispensing both viable cells and drug combinations. In particular, the dispensing of two or more compounds to create a dose-response matrix can be both labour intensive and compound expensive.
Miniaturizing qPCR assays and simplifying standard curve preparations
This application note demonstrates a successfully miniaturized qPCR assay with the Thermo Scientific™ Multidrop™ Pico 8 Digital Dispenser and PicoIT 8 software. In three simple steps, the PicoIT 8 software enables the setup of a qPCR assay plate including titrations of reagents needed for a standard curve. Then, with the Multidrop Pico 8 Digital Dispenser, the reagents for a miniaturized volume (5 µL reaction) in a 384-well qPCR assay plate are dispensed, mixed, and ready to be placed on the Applied Biosystems™ QuantStudio™ Real-Time PCR System for amplification. The results show how the Multidrop Pico 8 Digital Dispenser and PicoIT 8 software allows users to easily set up a miniaturized Applied Biosystems™ TaqMan® qPCR assay plate with successful amplification of the input cDNA.
Next-gen liquid dispensing from microliters to picoliters
Aaron Kettle, Senior Product Manager at Thermo Fisher Scientific, presents two automated liquid handling systems: the Multidrop™ Combi+ Reagent Dispenser and the Multidrop™ Pico™ 8 Digital Dispenser.
The Multidrop™ Combi+ delivers fast, microliter-level dispensing for reagents and cell lines into well plates, ensuring high-speed, efficient workflows. Meanwhile, the Multidrop™ Pico™ 8 is designed for ultra-precise, low-volume liquid handling, making it ideal for applications requiring accuracy at the picoliter scale.
Both systems are tailored for the pharmaceutical and biotech industries, offering reliable performance, intuitive software, and seamless automation to enhance efficiency and reproducibility in the lab.
This video was filmed at SLAS2025.
Thermo Scientific Multidrop Pico 8 Digital Dispenser
Simplify assay set up while saving on compounds, reagents and time with the new Thermo Scientific™ Multidrop™ Pico™ 8 Digital Dispenser.
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