Complement Biomarker Assays
Complement biomarker assays target selected biomarkers of high relevance. These assays are important and well-suited for analyses in drug development and academic research. They stand out with very low cross-reactivity and high specificity as they bind neo-epitopes of cleaved products or complexes, where this is relevant.
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Svar's Complement Biomarker assays are flexible and easy to use enzyme immunoassays with ready to use reagents and short incubation times leading to reduced hands-on-time for the user. Svar's complement biomarkers are well-suited for safety testing studies of complement activation in drug development and medical devices, i.e., biological safety testing, and as part of the recommended tests for assessing complement activation according to ISO standard 10993-4 for hemocompatibility testing.
The portfolio contains:
- Complement C4d [COMPL C4d RUO]: C4d is the cleave product of C4, located at the very beginning of both classical and lectin pathway
- Complement TCC [COMPL TCC RUO]: TCC detects the soluble TCC formed at the terminal end of the complement cascade.
- Complement Factor P [CFP-F and CFP-Q]: Factor P, or Properdin, is the only positive regulator of the complement cascade, involved in stabilizing the C3-convertase of the alternative pathway and C5-convertase. Svars Factor P assay comes as both quantitative and functional, the latter Svar is alone in offering globally.
A guide to complement therapeutics for drug development professionals
This comprehensive eBook covers the fundamental aspects of complement therapeutics, ranging from the basics of the complement system to the challenges and opportunities in drug development.
It aims to provide practical insights into the development process, regulatory considerations, and the broader landscape of complement-targeted therapies. The inclusion of case studies, editorial articles, and scientific material is intended to add depth and relevance for professionals in the pharmaceutical industry.
Download to:
- Discover an introduction of the complement system
- Gain an understanding of the fundamental components of complement
- Explore the complement’s prospective therapeutic targets
- Engage with in-depth discussions on biomarkers, monoclonal antibodies (mAbs), and aptamers
- Understand the significance of complement within novel modalities like gene therapy
The complement system provides promise of novel prognostic biomarkers for cancer
The context-dependent role of the complement system in cancer has the potential to provide novel prognostic biomarkers to inform treatment decisions for cancer patients
The role of the complement system in infectious disease: Expert opinion on future diagnostic and therapeutic potentials
Explore the role of the complement system in infectious disease and discover the immunoassays that drive research, diagnostics, and therapeutic monitoring
Novel COVID-19 biomarkers - The role of complement C4d and calprotectin
Dr. Marie-Agnès Dragon-Durey highlights the role of complement C4d and calprotectin in the detection, diagnosis, and treatment of viral infectious diseases
