Reconstructed Bone (r-Bone™) 3D Cell Culture Service, Mulitiple Myeloma
Human, bone marrow 3D culture model enabling accurate testing of therapeutic agents against multiple myeloma.
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Reconstructed Bone (r-Bone) platform offers 1-to-1 reconstruction of cellular and extracellular compartments of the human bone marrow microenvironment. r-Bone preserves the architecture of human bone marrow and enables accurate evaluation of response to treatment.
Unique Advantages:
- Clinically relevant system demonstrating high correlation with clinical outcomes (in a clinical study, 19 out 21 cases of response vs. resistance to treatment were predicted correctly).
- Supports evaluation of efficacy and toxicity in a single assay.
- Suitable for testing of immuno-oncology agents.
- Comprehensive system to ascertain mechanisms of drug resistance.
Features:
- Bone marrow-specific extracellular matrix (ECM) drives native organization of primary multiple myeloma cells ex vivo.
- Multiple myeloma medium supplement enables reconstruction of a disease-specific mileu.
- Long-term survival of primary patient cells (viability is maintained for >30 days as compared to 1-4 days in standard 2D culture or Matrigel).
- Maintains cellular heterogeneity of the primary human bone marrow.
- Suitable for evaluation of single agents and combination treatments.
- Compatible with multiple therapeutic modalities, e.g. small molecules, antibody-drug conjugates (ADC), immuno-oncology agents, including CAR-T cells.
- Compatible with standard readouts, such as FACs, imaging, bioassays, etc.
Next generation 3D patient-derived cell culture services
In this overview, zPREDICTA demonstrates their 3D culture serivces based on their unique proprietary technology, where organ-specific extracellular matrix and disease-specific medium supplements provide a physiologically relevant microenvironment for accurate testing of anticancer compounds.
Testing immuno-oncology agents in organ-specific 3D cell culture models
In this application note, zPREDICTA demonstrates their 3D culture services based on their tumorspecific technology, where tissue-specific extracellular matrix (ECM) and tumor-specific medium supplements provide a physiologically relevant tumor microenvironment for accurate testing of anticancer compounds.
r-Bone: 3D culture platform for testing agents against AML and multiple myeloma
In this application note, zPREDICTA demonstrates their reconstructed bone marrow (r -Bone) platform, which holds the ability to sustain long-term viability and preserve proliferative properties of primary bone marrow. r-Bone replicates the comprehensive 3D microenvironment of the human bone marrow from patients with multiple myeloma and AML, allowing for more in-depth research to be performed.
Reconstructed Bone (r-Bone™) technology
In this application note, zPREDICTA describes the Reconstructed Bone (r-Bone™) technology, a patient-derived 3D tissue culture model where the human bone marrow microenvironment is reconstructed in vitro. This technology is capable of supporting long-term survival and expansion of primary multiple myeloma cells and cells from other hematological malignancies, meaning the complex interactions between cells and their microenvironment may be studied.
