RapID - Portable Raw Material ID Verification
The RapID Raman system is the next generation in raw material testing for pharmaceutical GMP quality control. RapID is a portable Raman spectrometer that uses Agilent’s spatially offset Raman spectroscopy (SORS) technology to extend high-throughput spectroscopic analysis through clear packaging to nontransparent and colored containers. This unique capability makes RapID ideally suited to noninvasive raw material identity veri…
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Excellent results and technology
Confirmatory ID for raw materials
The Rapid Raman is an excellent tool to help us improve our current flow to release raw materials to the manufacturing are. It's a non invasive test, meaning no sampling is required, so you save time and money after the implementation.
Review Date: 29 Mar 2022 | Agilent Technologies
The RapID Raman system is the next generation in raw material testing for pharmaceutical GMP quality control. RapID is a portable Raman spectrometer that uses Agilent’s spatially offset Raman spectroscopy (SORS) technology to extend high-throughput spectroscopic analysis through clear packaging to nontransparent and colored containers. This unique capability makes RapID ideally suited to noninvasive raw material identity verification.
With conventional techniques, raw material testing in opaque containers can create a bottleneck in pharmaceutical manufacturing. A dedicated sampling area is needed to open, sample, test, and reseal each container to verify the identity of the contents. The RapID system allows the operator to verify the contents of each container through opaque and colored packaging in seconds, enabling release immediately into production. This saving on handling and lab testing reduces the overhead from hours or days to only minutes per batch.
Features:
- Portable Raman ID through opaque and colored sacks, tubs, and bottles
- 100% ID testing for all incoming containers
- Faster ID workflow
- Reduce operator time and sample-handling booth usage
- No contamination—better for quality and operator exposure
- Avoid sampling, maintain sterility, and prevent cross-contamination
- Sterile manufacturing of parenteral and biological products benefits from the RapID system's noninvasive approach
- Compatible with most containers, APIs, and excipients—unlike conventional handheld Raman devices, the RapID system is compatible with multilayer paper and plastic sacks, opaque plastic drums, and thick amber glass bottles
- Optional RapID magnetic nozzle attachments are available for simple and reversible adaptation, making it easier to work with containers such as amber glass and plastic bottles
Brochures
Agilent RapID Raman - Through-Barrier Raw Material Identity Verification
Raman is the most practical technique for raw material identity verification but it often requires a sampling step, which limits its ease and speed of use. Unique to Agilent, our proprietary spatially offset Raman spectroscopy (SORS) technology enables identification of most common materials through unopened opaque packaging, unlike conventional handheld Raman devices. The Agilent RapID Raman system is the fastest way to verify pharmaceutical raw materials and the most cost-effective means for high throughput or 100% testing.
Raw Material Identity Verification in Biopharmaceutical Production Using the Agilent RapID Raman System
Biological compounds derived from living cells offer exciting possibilities for treatment of a growing number of medical conditions. Most biologically derived proteins cannot be terminally sterilized and must be produced under aseptic conditions. This Application Note describes the use of spatially offset Raman spectroscopy (SORS) and the Agilent RapID Raman system for verifying common starting materials in biological production without compromising sterility.
Raw Material Identity Verification in Sterile Manufacturing Using the Agilent RapID Raman System
Avoiding contamination in the manufacture of parenteral, intravenous, and other sterile products is essential. However, verifying the identity of incoming materials typically involves opening the packaging and exposing both the contents and the operator. The Agilent RapID Raman system verifies material identity through unopened nontransparent containers. This Application Note highlights the ability of the RapID system to analyze materials typically used in sterile manufacturing without compromising the container’s seal.
Through-Container Identity Verification of Polysorbates with the Agilent RapID Raman System
Polysorbates are often packaged in a sealed, oxygen-free environment to prevent degradation. Amber glass bottles are common containers for polysorbates, often used in large numbers, making identification difficult and time-consuming. Manufacturers of polysorbates typically make different grades, so reliable identity verification is essential to mitigate mistakes in supply. This Application Note describes how the Agilent RapID Raman system can unambiguously verify the identity of the four common pharmaceutical grades of polysorbates through unopened amber glass bottles.
RapID: A better way to ID raw materials
The RapID system is the next generation in portable Raman raw materials ID verification, extending high-throughput spectroscopic analysis through clear packaging to nontransparent and colored containers, including multi-layer paper sacks.
