Maestro Edge by Axion BioSystems

The Maestro Edge multiwell MEA and Impedance system allows you to capture the complex biology of your cells. Whether monitoring the kinetics of cellular growth and death or recording the activity of excitable cells; the Maestro Edge can help you record it noninvasively, in real time, and with software tools to make analysis quick and painless.

Don’t miss a datapoint. Capture the complexity of your live-cell assay from start to end. While traditional end point assays may perturb or destroy your cells in the process, the Maestro Edge automatically collects data without disturbing the cells. With fully integrated incubation, the Maestro Edge’s small benchtop footprint conserves space in the lab and requires no additional incubator.

With multiwell microplates, multiple assays can be performed simultaneously.

The Maestro Edge allows you to record multielectrode array (MEA) data from electrically active cells (e.g. neurons, cardiac cells, muscle cells, retina, and zebrafish) as well as cell proliferation, death, morphology, attachment, barrier function, and signaling using impedance. No matter the assay, the environmentally controlled chamber will record physiological responses without perturbing the cells.

The Maestro Edge platform delivers an easy-to-use, compact cellular analysis system suitable for any lab.

KEY FEATURES

• Measure cellular activity label-free and real-time - The Maestro Edge detects key parameters of neural network activity, cardiac functionality, and cell growth, death and attachment.

• Precisely control the cells environment - Cells are a product of their environment. Maestro Edge has a smart environmental chamber that finely controls temperature and CO₂ while rejecting electrical noise and mechanical vibrations.

• Connect to your network - 384 electrodes simultaneously record from your cells with the Neural, Cardiac, and MEA Viability modules. Now you can understand life’s circuitry label-free and in real time in 6- or 24-well plates.

• Continuous cell monitoring - 96 simultaneous live recordings from your cells with the Impedance module. Track cell proliferation, morphology, and viability in real time.

• See your cells - Sometimes you just want to look at your cells under a microscope. Maestro’s CytoView patented transparent circuit technology allows cell visualization and assay multiplexing.

• Control cellular activity - Recreate specific patterns of cellular activity using electrical stimulation or light pluses (with the Lumos optical stimulation system).

• Start your assay with the push of a button - “One button setup,” means temperature and CO₂ levels automatically adjust on plate docking. Plate usage is logged via an integrated plate barcode scanner for convenient experiment tracking.

• Monitor the kinetics of your biology on your smartphone - No need to be in lab. With the Impedance module, track changes in cell proliferation, viability, and cell killing over minutes or weeks.

MEA Applications include but are not limited to:

• Cardio- and neurotoxicity evaluations
• Cardiomyocyte classification and development
• Cardiomyocyte Inotropy
• Neural organoids
• Neural co-culture populations i.e. neurons and glia cells
• Neurological and neurodegenerative diseases i.e. ALS, autism, epilepsy
• Neuromuscular junctions
• Zebrafish

Impedance-based assays include but are not limited to:

• Barrier function/TEER
• Cell proliferation, migration and invasion
• Cytotoxicity and cell viability
• Immuno-oncology
• Viral studies