Incucyte® SX1 Live-Cell Analysis System
Designed with smaller labs in mind.
Incucyte® SX1 Live-Cell Analysis System
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The Incucyte® SX1 Live-Cell Analysis System automatically acquires and analyzes images around the clock, enabling you to derive deeper and more physiologically relevant information about your cells, plus real-time kinetic data — without ever removing your cells from the incubator. Change can happen in an instant. Whether simply assaying cell health or more complex processes like migration, invasion, or immune cell killing, see what your cells are doing and when they do it.
The Incucyte® SX1 instrument, proprietary assays and reagents provide you with the ability to gain new insights into biological processes via real-time, quantitative analysis of live cells. Conventional approaches to cell analysis only capture a single time point, enabling only single-point and end-point measurements, and cells are perturbed or destroyed as part of the assay process.
The Incucyte® system offers the advantage of performing live-cell analysis without ever having to displace cells or disrupt their surroundings. The system automatically and continually collects and analyzes images throughout the course of an experiment while cells remain unperturbed in a physiologically relevant environment.
Incucyte® technology is featured in over 3,000 peer-reviewed publications in journals such as Nature, Chemical Society Reviews, Nature Medicine, and Nature Genetics, among many others. The SX1 enables even first-time users to set-up an experiment and begin acquiring images within minutes. Image viewing, analysis and graphing is similarly streamlined – images from a 96-well experiment can be viewed simultaneously, then converted into movies, metrics, and corresponding publication- and presentation-ready graphs with just a few clicks. In addition to improving productivity for the individual user. Data is accessible remotely to a user via unlimited, free networked licenses. In addition to the Incucyte® platform, Incucyte® proprietary reagents and analysis software are also available which enable researchers to perform real-time, quantitative live cell analysis and evaluate a wide variety of cellular processes over time.
Brochures
Technical specifications: Incucyte SX1 Live-Cell Analysis System
All the technical specifications you need to consider when purchasing the Incucyte® SX1 Live-Cell Analysis System by Sartorius Group.
Live-cell imaging for label-free toxicology analysis of hepatic organoids
Conventional 2D cultures of primary hepatocytes or established hepatic cell lines do not provide a true representation of the cellular mechanisms observed in vivo. In this webinar we will demonstrate an efficient and consistent protocol developed by STEMCELL Technologies to extract, grow, and differentiate liver cells in a complex 3D organoid culture system. These organoids more closely resemble the human liver and can be used in standard and high throughput assays to accommodate both academic and industry research needs.
This webinar will demonstrate the use of hepatic organoid cultures to validate a label-free live-cell toxicology screen using a powerful and flexible Incucyte® Live-Cell Analysis System.
Key learning objectives
- Organoid cultures – from tissue to mature 3D organoid culture and their downstream analysis
- Real-time kinetic analysis of organoids
- Label-free live-cell toxicology screening
- Key challenges of compound validations and data interpretation to improve the efficacy of drug discovery workflow
Who should attend?
Both academic and industry researchers using 3D in vitro models.
Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
Real-time visualization and quantification of Akt activity using live-cell imaging
Kinase signaling plays a key role in coupling extracellular stimuli with numerous downstream cellular functions including proliferation, survival, and migration. These pathways are highly interconnected, and their dysregulation has been implicated in several disease processes, including cancer initiation and metastasis, and chronic inflammation. Akt is a serine/threonine protein kinase that is upregulated across various diseases and has been extensively studied as a therapeutic target. Studying dynamic changes in kinase activity can be difficult, with standard approaches being limited to endpoint assays which cannot monitor the effects of treatment over time.
In this webinar, John Rauch, senior scientist at Sartorius, and Jasmine Trigg, scientist at Sartorius, will demonstrate the utility of the Incucyte® Kinase Akt Lentivirus Reagent, encoding a kinase translocation reporter based on a green fluorescent protein-tagged Akt substrate whose subcellular localization is phosphorylation-dependent, and a red fluorescent nuclear protein to denote the nuclear/cytoplasmic boundary. This biosensor enables Akt activity to be monitored in real-time, providing kinetic data on Akt activation and inhibition in living cells within a physiologically relevant environment.
Key learning objectives
- Gain an overview of validated assays combining the Incucyte® Kinase Akt Lentivirus Reagent and the Incucyte® Live-Cell Analysis System for image-based fluorescent readouts of Akt activity.
- Discover guidance on experimental set-up and how live-cell analysis can be built into your development workflow.
- Learn about case study data to support the use of live-cell analysis within the fields of oncology, inflammation and neuroscience.
Who should attend?
- Researchers involved in fundamental research and therapeutic development.
- Scientists interested in quantifying Akt activity, and its modulation, within the fields of oncology, inflammation, and neuroscience.
- Individuals who desire to implement live-cell imaging into their workflow.
Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
Classification of cell morphology with advanced multivariate analysis
Watch this on-demand webinar to discover a user-friendly workflow that yields quantitative analysis of a wide range of biological models
