Incucyte® Immune Cell Killing Assays
Visualize and measure immune cell/ T cell killing in real time.
Visualize immune cell/tumor cell interplay
Figures 3D Immune cell Killing (measure ADCC in tumor sphero
Figures 3D Immune cell Killing (measure ADCC in tumor sphero
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In combination with the Incucyte® Live-Cell Analysis System, an integrated solution for continuous visualization and automated analysis of immune cell-mediated killing of tumor cells – all within your tissue culture incubator.
Features:
- Ideal for cytotoxic T cell killing, antibody-dependent cell-mediated cytotoxicity (ADCC), and immune cell killing in tumor spheroid models.
- Real-time visualization and fully automated analysis of interaction and killing in immune cell-tumor cell models.
- Real-time visualization and analysis of cellular interaction and killing. Direct measurements of tumor cell death and viability.
- Make relevant measurements in a highly flexible assay format.
- Mix-and-read 96/384-well assays suitable for screening.
The evolution of immune cell killing assays using live-cell analysis
In this white paper, Sartorius discusses how live-cell analysis can enhance data analytics and translational models. This white paper uses examples from cancer therapeutic research, exploring the patient's own immune system and the role it plays in inducing malignant cell death of tumor cells. Find out more about how the use of live-cell analysis could become a solution to current and future challenges in immuno-oncology research.
Analyzing Cell Subsets and Heterogeneity from Live Cells
Considerable heterogeneity of individual cells exists even in the simplest cell system. Such heterogeneity is mirrored by the diversity of pharmacological responses at the cellular level, where even seemingly identical cells may respond differently to drug treatments and perturbagens. Hence, analysis at the cell-by-cell level promises additional biological insights beyond which whole population measures may deliver. In this white paper, we illustrate techniques of analyzing living cells over time, and describe new, industrial-scale analysis solutions for quantifying the phenotypic biology of cell subsets in heterogeneous cultures.
Novel Kinetic Live Cell Imaging Assays for Immune Cell Killing of Tumor Cells
Cancer immunotherapy offers the potential for specific eradication of tumor cells and the prevention of cancer recurrence. This poster describes the use of fully kinetic live cell imaging assays to quantify T cell mediated killing of tumor cells in co-culture. Phase and 2-colour fluorescence images were captured using IncuCyte ZOOM™. These HD images and time-lapse movies facilitate a clear understanding and compelling verification of the underlying biology.
Analysis of Immune Cell Killing of Tumor Cells Using the IncuCyte® System
This video shows time-lapse movies acquired using IncuCyte® ZOOM live-cell analysis system showing a T cell sub population of PBMCs, activated with anti-CD3 antibody and IL-2, killing target SK-OV-3 tumor cells.
The third edition of the Live-Cell Analysis Handbook published
Latest edition includes two new chapters for scientists who perform cell biology assays
How to Use Live-Cell Analysis for Neuroscience Applications
Learn how live-cell analysis techniques can benefit your neuroscience research, in this expert on-demand masterclass
