GCMS-TQ8050 NX Triple Quad Mass Spectrometer

Nitrosamines, also known as N-nitrosamines, refer to any molecule with a nitroso functional group (NO⁺) bonded to a deprotonated amine. Nitrosamine impurities are of particular concern as there is evidence that they can be carcinogenic, and therefore their presence in medicines is considered unacceptable.

In this free eBook, discover a range of ultra-fast mass spectrometry technologies for the quantification of trace levels of nitrosamine impurities from various drug substances, drug products, and solvents.

This eBook will also cover:

• Sartan analysis
• Metformin analysis
• Other API analyses
• Residual solvent analysis

With the increase in medicinal and recreational cannabis legislation throughout the United States, there is an emerging demand for pesticide testing on cannabis products. In this application note, Shimadzu demonstrates the use of atmospheric pressure chemical ionization (ACPI) and liquid chromatography-mass spectrometry (LCMS), while also exploring the utility of LCMS for the analysis of complete California and Oregon pesticide lists for cannabis.

In this application note, Shimadzu explores the various techniques for the analysis of cannabinoids and terpenes, highlighting techniques like high-performance liquid chromatography (HPLC) and the use of single quadrupole liquid chromatograph mass spectrometers (LCMS).

USEPA method 608 is GC-ECD method to determine Aroclor and organochlorine pesticides. This method requires the use of second column for confirming the detected compounds due to the low selectivity of the ECD detector comparing with GC-MS/MS. Also pattern recognition is required for accurate identification of Aroclors. Triple quadrupole GC-MS/MS based method offers a solution for the GC-ECD method’s drawbacks by providing high selective analysis. In addition, the type and concentration of Aroclor can be simultaneously determined.

As the global population continues to increase, food security becomes a greater concern. This places significant pressure on agricultural producers to grow food in a faster, safer and more sustainable fashion. Faced with this challenge, many farmers use pesticides to protect crops from environmental pests, such as weeds (herbicides), insects (insecticides) and fungus (fungicides).

For many forensic laboratories, there is a need for a simpler, faster and more effective way to conduct analysis. These labs face the challenge of delivering accurate results for an increasing number of samples. To improve productivity and confidence in results, they need more advanced instrumentation and software solutions designed specifically for forensic analysis.

Precursors of perfluoro compounds (PFCs) such as perdluorooctane sulfon-amides (FOSEs, FOSAs) and acrylates (FTAs), which may potentially degrade to perdluorooctane sulfonate (PFOS) and perflurooctanoic acid (PFOA), are analysed via an electron ionization-multiple reaction monitoring (EI-MRM) method and a positive chemical ionization-selective ion monitoring (PCI-SIM) method. For all targets, both acquisition methods report a limit of quantitation (LOQ) value of 5.0 ng/mL. The EI-MRM method provides a lower limit of detection (LOD) than the PCI-SIM method, LOD of the former is as low as 0.5 ng/mL whereas that of the latter is 4.0 ng/mL.

Routine analysis and reporting of volatile and semivolatile organic compounds (VOCs and SVOCs) in environmental samples is well established, defined and standardized by the Environmental Protection Agency (EPA) and other organizations. However, cutting-edge GC-MS technology is redefining laboratories’ performance for environmental analysis, whether using single or triple quadrupole mass spectrometry.

Yoshiro Hiramatsu, GC-MS Product Liaison and Dr. Ruth Marfil-Vega, Senior Market Manager, Shimadzu Scientific Instruments, will explore how Shimadzu’s latest GC-MS instruments, in combination with the multi-platform software LabSolutions and LabSolutions Insight, enable successful detection, quantitation, and suspect screening of VOCs and SVOCs. Plus, discover how these tools support EPA methods, from initial sample analysis to final data reporting.

Key learning objectives

• Learn how to boost throughput with the use of an enhanced tuning algorithm, faster data acquisition, and other novel GC-MS designs for prolonged stability and shorter analysis time
• Find out how to effectively mitigate human error, minimize rework, and reduce operational costs with advanced GC-MS technology to simplify maintenance and routine analysis
• Discover how to streamline data processing and reporting through AI-assisted data integration for EPA and other environmental methods

Who should attend?

• Lab managers
• Environmental analytical chemists
• Water quality professionals
• GC-MS users
• Environmental analysts
• Environmental laboratory managers

Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.

Making more space for high-performance analyses

An automated sample management system paired with a triple quadrupole mass spectrometer is said to drastically shorten analysis time

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