Echo® 550 Liquid Handler
Imagine preparing assay plates for siRNA screening, compound screening with biochemical and cell-based assays, PCR reactions and more all on a single liquid handling platform, with no tips and no cross-contamination. Labcyte has developed new acoustic droplet ejection (ADE) parameters that deliver built-in intelligence to enable users to transfer many different fluid types from a single instrument. All Echo systems come pre-ca…
Great liquid dispenser, a must have!
Acoustic compound/reagent dispenser
Echo 550 allows users to dispense compounds or reagents in nL quantity, which not only reduces the amount of compound/regent required for running experiments but also provides a safer way to dispense compounds with unknown safety profiles. The Echo Dose-response software requires some training before use, but the dispense reports generated from the software can be imported into LIMS, which is great for analyzing HTS assays. The Echo Plate Reformat software is very intuitive to use and is a great tool for running any exploratory assay. This software is the most popular amount the users in my lab. The weekly maintenance for this instrument is very minimal, but we do need to reach out to the Labcyte engineer when an error occurs since the instrument is quite complex. Overall, Echo 550 has become an essential instrument for in vitro drug discovery in our lab, especially for running any high throughput screening campaigns.
Review Date: 18 Mar 2021
Liquid
I love the ECHO. Great product. Maybe a little expensive for startups.
Review Date: 28 Jan 2020
Truly enabling technology.
Acoustic to MS for analysis
Game changing technology. will enable entirely new workflow in pharmaceutical industry.
Review Date: 27 Jan 2020
Dramatically improved the quality of my experiments.
Enzyme inhibitor profiling
This instrument has dramatically improved the quality of my experiments. Initially it was to get rid of tips and DMSO while now it is changing the way to setup new assays and re-designing the already setup.
Review Date: 17 Dec 2018
What a great instrument, with good customer service on an already reliable machine.
Cell-based compound profiling
The draw of the Labcyte Echo 555 Liquid Handler is the speed at which compounds can be added to 384-well plates, and the accuracy and flexibility in which it does it for full integration into a robotic system. The ability to add nanoliter volumes in seconds is of incredible value to large batches of plated cells, and the service is impeccable. I cannot imagine trying to screen the number of compounds against multiple cell lines without the Echo.
Review Date: 30 Nov 2018
I cannot work efficiently without the ECHO.
Drug Discovery
ECHO is one of my favorite machine in the lab. I can use the machine to dispense small volume ( minimum: 2.5 nl). The machine has 3 different programs: Cherry Pick, Dose response, and Plate reformat. It is so convenient for high throughput screening. It is very important to have ECHO for Drug Discovery because to can test/screen a lot of compounds and use a very small amount of precious compounds. The machine is reliable, save you time, and very efficient. When I show people around the lab, I show them the ECHO first.
Review Date: 26 Jul 2018
Makes dose response much easier!
liquid handling
The ECHO acoustic liquid handler is easy to use and makes setting up dose-response curves of many samples so much easier and quicker than by hand. It is also much more accurate than using a normal pipette as it dispenses 2.5nl droplets.
Review Date: 19 Feb 2018
Great
High Throughput Screening Assays
Reliable and efficient instrument, great for chemicals addition, dose curves, cell treatment.
Review Date: 24 Mar 2017
Great Echo.
Compound Plate preparation and Assay Plate dosing
We are now having 2 sets of Echo 555. One is installed in May 2008 and it's the first Echo coming into China, with the help of Eric Tang. As with the first one, we met some problems but we overcame them all with the help of Hiro. Both have served us very well.
Review Date: 3 Feb 2017
Efficient, reliable.
Assay Development, HTS, HCS
ECHO is one of my favorite instruments in my lab. It can transfer compounds in different formats: Dose Response, Cherry Picking, Plate reformat. It also generates a report after each task. Very easy to use and pretty reliable.
Review Date: 19 May 2016
Imagine preparing assay plates for siRNA screening, compound screening with biochemical and cell-based assays, PCR reactions and more all on a single liquid handling platform, with no tips and no cross-contamination. Labcyte has developed new acoustic droplet ejection (ADE) parameters that deliver built-in intelligence to enable users to transfer many different fluid types from a single instrument. All Echo systems come pre-calibrated so that you can switch among different fluid types with just a click of the mouse. No further adjustment is required for you to be productive immediately. These developments combine the latest discoveries in wavelength, power and timing requirements for ADE with real-time fluid measurement at multiple points during a run. The resulting algorithms solve some of the most significant liquid handling challenges with volatile, low-surface tension and/or meniscus-shifting fluids. Volumetric accuracy and precision for all fluids tested so far—including buffers, nucleic acid and protein solutions, surfactants, serum and cell culture media—are comparable to established performance with DMSO.
The Echo® 550 liquid handler introduced the world to acoustic droplet ejection (ADE). This award-winning instrument remains the proven choice for low-volume liquid handling in leading pharmaceutical and biotechnology companies worldwide. Like the Echo 520 and Echo 555 liquid handlers, the Echo 550 uses "touchless" ADE transfer technology. ADE uses sound energy to transfer 2.5 nL droplets from Echo-qualified 384- and 1536-well source plates into 96-, 384-, 1536- and 3456-well destination plates. This unique touchless technology eliminates consumable tip costs, washing, and cross-contamination. Unsurpassed volumetric precision (≤ 8% CV) and accuracy (≤ 10% CV) ensure superior results. Independent studies have shown that Echo liquid handlers eliminate false negatives due to sample loss on tip surfaces in low-concentration transfers. Like the Echo 555 liquid handler, the Echo 550 liquid handler reports both fluid volume and DMSO hydration.
Applications:
Compound management
Compound screening
siRNA screening
Biochemical assays
Cell-based assays
PCR
Genotyping
Gene expression
