BIOshell UHPLC and HPLC Columns by Merck

Manufacturer Merck  |  Available Worldwide
BIOshell™ HPLC and UHPLC columns deliver maximum speed and efficiency for the separation of biomolecules on both HPLC and UHPLC systems. The novel, superficially porous silica particles (SPP), with pore sizes from 90 Å up to 1000 Å, allow the separation of glycans as well as of very large proteins.


BIOshell UHPLC and HPLC Columns by Merck product image
BIOshell UHPLC and HPLC Columns
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BIOshell™ HPLC and UHPLC columns are based on Fused-Core® particles in different particle sizes, core and shell dimensions and pore sizes to meet your individual needs.

Key Features:

  • Superior Efficiency in UHPLC: 2.0 µm SPP particle with 160 Å pores. Ideal for the ultra-fast separation of peptides in UHPLC
  • UHPLC Performance with HPLC Back Pressures: 2.7 µm SPP particle with 90 Å, 160 Å and 1000 Å pores. Ideal for the separation of glycans, peptides and large proteins*
  • Minimal Mass Transfer Effects for Enhanced Performance: 3.4 µm SPP particle with 400 Å pores. Ideal for separation of proteins. 0.2 µm porous shell minimizes band broadening due to mass transfer effects.
  • Enhanced Performance in HPLC: 5 µm SPP particle with 160 Å pores. Ideal for the separation of peptides on standard HPLC instruments

A wide range of BIOshell™ HPLC and U/HPLC columns, with its range of particle sizes, pores and column chemistries, allows the perfect selection of a column to maximize the chromatographic performance of your next biomacromolecule separation.

All BIOshell™ columns are compatible with LC/MS instrumentation as they have been extensively tested for column bleed and exhibit near zero bleeding.

Relevant applications:

  • HPLC Analysis of Apotransferrin Tryptic Digest
  • HPLC Analysis of Insulin Variants and Analogs
  • UHPLC Analysis of Peptides
  • HPLC Analysis of N-Linked Glycans
  • HPLC Analysis of Protein Standard

Product Overview

BIOshell UHPLC and HPLC Columns by Merck product image

BIOshell UHPLC and HPLC Columns

Manufacturer Merck  |  Available Worldwide

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