Arc HPLC System
Count on the Waters Arc™ HPLC System for high-efficiency separations and quality data to help meet your regulatory requirements with confidence. The Arc HPLC system allows you to easily replicate and improve the performance of existing LC methods without compromising data quality.
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Easy to use and reliable
Drug analysis
The Waters ARC HPLC is a reliable and user-friendly system for routine analytical work. It provides stable results, good sensitivity, and smooth operation for both research and quality control laboratories. The instrument is easy to maintain, and the software interface makes method development and data analysis straightforward. Overall, it is a dependable HPLC system that delivers consistent performance and is suitable for everyday chromatography needs.
Review Date: 24 Nov 2025 | Waters
Great instrument! Balance of performance and value !
Chromatographic Separation
With the Arc HPLC System, the USP assay for losartan potassium met all of the system suitability requirements, including injection precision <0.5%. Comparison of the Arc HPLC System to competitive HPLC systems demonstrates leading performance in USP efficiency, USP tailing, and injection precision.
Review Date: 17 May 2022 | Waters
We’re always open to new business opportunities. Arc HPLC’s a useful tool for a CRO.
Biopharma
The ARC HPLC performed very well in our testing. Unique features, such as Gradient SmartStart, which can adjust the injection relative to the gradient start to emulate other HPLC systems’ dwell volumes, have a practical application to our work, and this instrument has potential to be very beneficial to us.
Review Date: 11 Apr 2022 | Waters
I was happy to work on the ARC HPLC system by Waters
Refractive index, photodiode array, UV/Vis, fluorescence
Greater robustness and high injection precision reproducibility of the results
Review Date: 2 Apr 2022 | Waters
Instrument provides less maintance cost and accurate results
Pharmaceutical analysis
Very useful and easy to use to analyse the pharmaceutical molecule, it is also user friendly and gives accurate and precise results.
Review Date: 8 Feb 2022 | Waters
Meets only niche activities and needs more maintenance.
Impurities analysis and pharmaceutical drug development analysis
The ARC HPLC from Waters is intended to bridge the gap between UPLC and routine HPLC. But, buying this instrument to perform UPLC application would be an accident. This instrument performs well as an HPLC and to an extent, helps in applications which need to use columns with particle sizes between 1.9 & 2.5 µm. The system is very sensitive to high buffer concentrates and easily gets choked and cannot be washed with hot water like the routine Alliance HPLC. Care needs to be taken that the system may not be recommended for routine development use, but works well with specific needs of the development lab.
Review Date: 18 Mar 2021 | Waters
Best partner in our daily work.
QC ANALYSIS
Waters new ARC HPLC’s performance has been improved, but cost has stayed relatively flat. Together with the Empower network system it is the best partner of QC analyst especially for pharma industry.
Review Date: 9 Feb 2021 | Waters
Absolutely nice instrument
Separations techniques
Very effective, the results are very accurate and dependable and it’s easy to use. The machine is very easy to maintain.
Review Date: 9 Feb 2021 | Waters
Best performance and robustness
QC
The best performance ever with the instrument, exceeding expectations in service and support, an intuitive and robust system.
Review Date: 9 Feb 2021 | Waters
Great instrument, our lab wouldn't be the same without it.
Leachable\extractables
We have a Waters Arc HPLC with QDa in our lab for doing leachable/extractable testing. It is user-friendly and easy to learn for new employees like myself. There is almost no repairs or maintenance required because we never have any problems with it.
Review Date: 9 Feb 2021 | Waters
The Arc HPLC System delivers the ideal balance of performance and value for right-the-first-time analysis and trusted test results:
- Enhance performance without redeveloping your method
- Run methods with greater robustness over traditional HPLCs
- Take advantage of low analyte carryover, high injection precision, and high back pressure tolerance for the easy replication, adjustment, and enhancement of existing HPLC methods
- Seamlessly receive transferred methods from Alliance™ HPLC or other HPLC platforms, preserving analyte retention time and reproducibility of your analysis
Brochures
Enhance the performance and efficiency of LC methods using the Arc HPLC System
In this brochure, Waters showcases the Arc HPLC, a modern liquid chromatography system that delivers high-efficiency separations to help meet your regulatory requirements with confidence. The system allows you to easily replicate and improve the performance of existing LC methods without compromising data quality, avoiding the burdens of older, less efficient LC systems.
Analysis of soft drink additives with no interference from aspartame degradants using Arc HPLC System with PDA detection
One potential issue in the analysis of soft drinks is aspartame degradation, because its degradants may co-elute and interfere with the quantification of the target additives. This application note from Waters describes an investigation into the degradation of aspartame and a method to eliminate any chromatographic inference from its degradants.
Analysis of water-soluble vitamins and caffeine in beverage and multivitamin products
This application note describes an analytical method for detecting and quantifying 10 water-soluble vitamins and caffeine in multivitamin tablets and beverages. The Arc HPLC-PDA combined with an XSelect HSS T3 XP analytical column enabled the separation of 10 vitamins and caffeine in 16-minutes.
Selecting a liquid chromatography solution for testing sugars and sweeteners in beverages
In this application guide, explore top tips and tricks to choosing the best liquid chromatography solution for your beverage analysis application. Explore how to gain optimal retention of target analytes, detection of analytes with no/low chromophore, and much more.
Analysis of sugar alcohols and allulose using an Arc HPLC System with refractive index detection
In this application note, an analytical method was developed to detect and quantify sugar alcohols and allulose in beverages and other low-calorie products. Arc HPLC-RI was combined with an Atlantis Premier BEH Z-HILIC analytical column, which provided an increase in polar analyte retention and offered a different selectivity when compared to other hydrophilic interaction liquid chromatography (HILIC) chemistries.
Method transfer for a fast gradient from a binary HPLC to an Arc HPLC System
In this application note, Waters demonstrates the method transfer for a fast gradient method from an HPLC legacy system to the Arc HPLC System. This application note explains how the quaternary Arc HPLC System is designed to provide greater injection precision with retention time repeatability comparable to the binary HPLC systems.
Arc HPLC System: Improved productivity and seamless transfer of an HPLC impurities method
Analytical methods used for testing of pharmaceutical raw materials and finished drug products are often transferred across organizations or to contract partners that utilize instruments from different vendors. In this application note, Waters demonstrates the seamless transfer of an HPLC impurities method to an Arc HPLC System and to a smaller particle column for improved laboratory efficiency and productivity.
Enhance the performance of your LC methods with the Arc HPLC System
Ever-evolving regulations are impacting LC method approaches for product quality control and beyond. The Arc™ HPLC System delivers high-efficiency separations to help meet your regulatory requirements with confidence. The system allows you to easily replicate and improve the performance of existing LC methods without compromising data quality, avoiding the burdens of older, less efficient LC systems.
Tools for chromatographic success: Ensuring data quality in routine analysis
Hear from the experts about how the new Waters Arc HPLC System easily addresses the challenges of pharma analysis, quality assurance, and compliance
New guidelines and modern chromatographic solutions converge to ensure data quality in the pharmaceutical laboratory
Join Waters on Wednesday, October 7, for a panel discussion and insights from the USP and MHRA
A simple step to upgrade your routine HPLC analysis
The new Arc HPLC System from Waters is exciting QC scientists with its promise of enhanced performance and effortless modernization from any HPLC legacy models
Ensuring data quality and addressing chromatographic challenges in routine pharmaceutical analysis: Tools for success
Explore current trends in regulatory observations referencing chromatography analyses in this upcoming webinar
Waters introduces the new Arc HPLC to help laboratories meet quality and production targets
Modern LC System replicates established test methods, delivers improved performance; updates to lab business continuity solution also announced
