ACQUITY UPLC H-Class PLUS System by Waters

Manufacturer Waters
4.5
/
5.0
  |  30 reviews
Transform standard procedures into ultimate performance.


ACQUITY UPLC H-Class PLUS System by Waters product image
ACQUITY UPLC H-Class PLUS System
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Average Rating: 4.5
30 Scientists have reviewed this product

5 out of 5
Ease of use
5 out of 5
After sales service
4 out of 5
Value for money


  • Status:

    Reviewer
  • Member since: 2020

  • Organization: United States Pharmacopeia



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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The results are great and reproducible.
Rating: 5.0

  • Application Area: Chromatographic method development

"The instrument is absolutely wonderful. Coming from grad school to the professional world, getting to use the H-class was lightyears ahead of what I had access to before. It makes method development a breeze."

Review date: 24 Nov 2020 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: INFARMED, IP



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great tool for HPLC and UPLC analysis.
Rating: 5.0

  • Application Area:Pharmaceuticals

"Reliable, stable, easy to use and a must-have instrument in any QC lab. It's perfect to upgrade from HPLC to UPLC, and to meet pharmacopoeial requirements, so it enables the laboratory to have more flexibility in testing."

Review date: 30 Oct 2020 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Advanced Reviewer

  • Member since: 2020

  • Organization: Novartis



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Waters Acquity H-Class UPLC: A robust and reliable instrument.
Rating: 5.0

  • Application Area:Small molecules drug products

"Water Acquity H-Class UPLC is a very robust technology in terms of efficiency and reliability of results. It's a very user friendly analytical instrument with good accuracy of results. Ease of use and after sale service are phenomenal."

Review date: 16 Jul 2020 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2020

  • Organization: Prinova



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Very nice equipment, reliable and worth the money.
Rating: 5.0

  • Application Area:Analytical use

"Very nice equipment, reliable and worth the money."

Review date: 12 Mar 2020 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Afcona Chemicals Sdn Bhd



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great and innovative product to help the industry with sample analysis.
Rating: 5.0

  • Application Area:Liquid Chrmomatography

"The time to analyse a sample is shorter with the minimum sample size compared to a normal HPLC, and it can analyse multiple samples per run.The technical team is useful and always give consultation when I encounter a problem."

Review date: 09 Mar 2020 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2020

  • Organization: Bal Seal Engineering



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Excellent instrument.
Rating: 5.0

  • Application Area:HPLC

"The Waters H-Class ACQUITY allows accurate samples to be analyzed within a very short period of time. Excellent instrument."

Review date: 06 Mar 2020 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2014

  • Organization: Amway



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Continued great product.
Rating: 5.0

  • Application Area:LC method development.

"The second generation of a workhorse product that is just as good as the orginal."

Review date: 06 Mar 2020 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2020

  • Organization: Washburn University



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    3 out of 5
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Good instrument.
Rating: 3.3

  • Application Area:Analysis of marijuana samples for concentration of THC

"Product got good values but product breaks down often. Used it for marijuana research to compare with a different LC and got better numbers."

Review date: 04 Mar 2020 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Advanced Reviewer

  • Member since: 2006

  • Organization: Robertet Flavors inc.



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    4 out of 5
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It cuts a lot of running time.
Rating: 3.7

  • Application Area:Food flavor compounds

"The instrument works very well. Fast runs and easy to control."

Review date: 12 Feb 2020 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Catalent Pharma Solutions



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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H-Class UPLC - the iPhone of chromatography. Durable, efficient and everyone's choice.
Rating: 5.0

  • Application Area:Pharmaceutical analysis in contract development industry

"Water's H-Class UPLCs are robust and very efficient for separation/detection when used in conjunction with UPLC columns. Their ability to withstand very high backpressures enables users to operate at faster rates, higher throughputs and much higher accuracy level. They are an excellent tool for any pharmaceutical development lab (predominantly CDMO) as you can screen, develop, optimize and validate your methods in a short period of time compared to traditional HPLCs."

Review date: 14 Nov 2019 | ACQUITY UPLC H-Class PLUS System


  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Med-Pharmex Inc



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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This is a very good UPLC instrument.
Rating: 4.3

  • Application Area:Method development and method validation of drugs

"This is a great UPLC system which can also be used for HPLC purposes. Reproducibility is very good. The consumables are easy to self replace. Also their after purchase service is great. I use this instrument to do method development and validations, and it has worked amazingly for me."

Review date: 11 Apr 2019 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Syngenta



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Easy to use.
Rating: 5.0

  • Application Area:Pesticides

"Excellent UPLC capabilities and great customer support."

Review date: 27 Mar 2019 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Bristol-Myers Squibb



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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Excellent support, excellent HPLC
Rating: 4.7

  • Application Area:Pharmaceutical analysis

"Excellent support, excellent UPLC. Reliable instrumentation. "

Review date: 26 Mar 2019 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Expert Reviewer

  • Member since: 2018

  • Organization: National University of Singapore, Singapore



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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Great product; value for money.
Rating: 4.3

  • Application Area:Characterization of your complex samples in small molecule

"Flexibility and robustness to run all the chromatographic modes. Improve characterization of your complex samples. Streamline your method development workflow. Support of your existing HPLC, UHPLC, and UPLC methods."

Review date: 19 Dec 2018 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Charles university



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great system
Rating: 4.7

  • Application Area:Pharmaceutical analysis

"Very effective uplc/uhplc system. In combination with empower software is very user friendly."

Review date: 19 Jun 2017 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2014

  • Organization: Peptides International Inc.



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Love it.
Rating: 4.7

  • Application Area:Peptides purity analysis

"The instrument delivers high quality results. The customer service is wonderful. The Empower software is not very easy to master, so I would give that element 3 stars."

Review date: 21 Nov 2016 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Centers for Disease Control and Prevention



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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This product enabled us to rapidly develop a new method
Rating: 5.0

  • Application Area:Analyze metabolites of diisocyanates

"A great product for method development. The quaternary pump allows for highly complex LC methods, and the multi column housing allows for easy changes between columns during method development."

Review date: 30 Mar 2016 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2015

  • Organization: Amherst Laboratories, Inc.



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    3 out of 5
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Rating: 3.3

  • Application Area:Routine and Stability Testing of Pharmaceutical Products and Raw Materials

"Using the Empower Software is very difficult at first but once you get used to it, you will realize that it is a very good software. Why? Because it keeps the integrity of your data. No matter how many times you re-process your chromatogram, it will keep the integrity of your original data by creating a new version every time a change is made on your chromatogram. Data integrity is an integral aspect in every laboratory. Also, Empower software is fully compliant with the requirements stated in 21 CFR Part 11 which is specific on electronic records and electronic signatures. "

Review date: 02 Nov 2015 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Advanced Reviewer

  • Member since: 2014

  • Organization: XEPA-SOUL PATTINSON (M) SDN BHD



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Rating: 5.0

  • Application Area:Pharmaceutical Analysis

"Very versatile model with a very user-friendly Empower software system."

Review date: 02 Nov 2015 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2015

  • Organization: SGS Lifescience services



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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Rating: 4.3

  • Application Area:Assay and related compounds for various drug products

"I love our H class UPLC system from Waters. We use it extensively for method developments and then for routine analysis after method validation. System is robust and reliable. Does not require a lot of service (so far, our system is relatively new). I think that system already pays off itself. "

Review date: 02 Nov 2015 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2015

  • Organization: DSM Fortitech



  • Ease of use
    2 out of 5
    After sales service
    3 out of 5
    Value for money
    2 out of 5
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Rating: 2.3

  • Application Area:Vitamin analysis

"High quality results, complex to use. Recommend to others"

Review date: 02 Nov 2015 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2012

  • Organization: Dexa Medic R&D



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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Easy to use with high quality results.
Rating: 4.7

  • Application Area:Generic development

"This product was effective in shortening the run times of HPLC methods. It was easy to use with high quality results. I can recommend if someone asks. After sales care was good with service and application support. Would be happy if can be bargained for less :-)"

Review date: 26 Oct 2015 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2012

  • Organization: BioVectra



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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Rating: 4.7

  • Application Area:Daily

"This instrument is high quality and ease-to-use. The technical service after sale is good and it offers value for the money although it is more expensive than HPLC."

Review date: 30 Jan 2015 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Expert Reviewer

  • Member since: 2012

  • Organization: EUROFINS Biomnis



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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Rating: 4.7

  • Application Area:UPLC, Toxicology, Forensics, Analytical Chemistry And More

"A very reliable an versatile UHPLC system. The reduced dead volume is really adapted to the new sub nano particles UPLC columns."

Review date: 23 Dec 2013 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2013

  • Organization: Pliva Croatia Ltd



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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Rating: 4.3

  • Application Area:pharmaceutical analysis

"Acquity UPLC H-Class System is very easy to use and if you have problems, you do not need to call for service at once as you can do most of the things by yourself. The parts, if they need to be changed, are not too expensive. A little problem is that nobody has educated us how to use such instrument, we had to do it by ourselves through practice."

Review date: 07 Aug 2013 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2013

  • Organization: na



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
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Rating: 4.3

  • Application Area:toxicology

"The software is easy to use. I can organize my runs by injection or by project. The only downfall is that HPLC protocols do not translate to UPLC...you may need to do some method development. I would recommend to a colleague since Waters is the world's leader in UPLC systems."

Review date: 28 May 2013 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2012

  • Organization: Merck



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    3 out of 5
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Rating: 3.7

  • Application Area:Biopharmacueticals

"The H-Class system is a valuable instrument for screening various buffers in ion-exchange methods with the quaternary pump and the Empower software developed to optimize pH and  salt gradients. The flowthrough needle allows for much less worry of carryover over the traditional Acquity instruments."

Review date: 28 May 2013 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2011

  • Organization: Bristol Myers Squibb



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Rating: 5.0
"Very easy to use. It gives the user the option to use as HPLC as well as UHPLC. Very convenient for method development as the pump can be used individually."

Review date: 28 May 2013 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2013

  • Organization: University of South Carolina



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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Rating: 4.7

  • Application Area:Forensics

"This instrument is very straight forward and is easy to use; once the sample is put into the sample chamber, and the conditions are set up, a sample set can be run overnight, with the option of automatic shut off after the last batch.  I would eagerly recommend this to a colleague.  Although I learned how to use the system with little trouble, my trainer had to learn how to use it by trial and, so I suppose a training session by a professional would be beneficial."

Review date: 28 May 2013 | ACQUITY UPLC H-Class PLUS System
  • Status:

    Reviewer

  • Member since: 2011

  • Organization: Abdi Ibrahim Pharmaceuticals



  • Ease of use
    3 out of 5
    After sales service
    4 out of 5
    Value for money
    3 out of 5
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Rating: 3.3
"Practical application, good performance in Method Transfer from HPLC to UPLC."

Review date: 17 Aug 2011 | ACQUITY UPLC H-Class PLUS System

Transform standard procedures into ultimate performance.

The ACQUITY UPLC H-Class PLUS System is the next evolution of UltraPerformance instrumentation, providing the highest resolution of any quaternary or binary LC System. Achieving true UPLC performance requires that system dispersion (or extra-column band spread) to be matched to the peak widths associated with narrowbore columns packed with sub-2-μm particles.  While other systems might be designed for high pressure, it doesn’t mean they're designed to deliver the sharp peaks associated with UPLC performance and the ACQUITY UPLC H-Class PLUS System.

Choosing the ACQUITY UPLC H-Class PLUS System enables you to continue running existing HPLC methods on a forward-looking LC platform, allowing you to confidently and seamlessly transition to UPLC separations - when you’re ready - using integrated system tools and reliable column kits for method transfer and method development that simplify migration. And, when paired with the ACQUITY QDa Detector, you can combine qualitative and quantitative data into the same workflow with complementary optical and mass detection.

ACQUITY UPLC H-Class PLUS System Features:

  • Flexibility of automated quaternary or binary solvent blending
  • Simplicity of flow-through-needle injections
  • UPLC resolution, sensitivity, throughput
  • Seamlessly transfer methods from HPLC to UPLC, and back
  • Runs HPLC until you’re ready for UPLC
  • Ideal for method development
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