ACQUITY UPLC H-Class PLUS System
Transform standard procedures into ultimate performance.
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Good results, sample manager tower too delicate.
Pharmaceutical
Very effective and good for Empower.
Review Date: 11 May 2023 | Waters
Less time consuming for sample analyses
Analyze metabolites on biological samples
Makes work easy with many samples
Review Date: 30 Mar 2022 | Waters
Makes analytical work easy and fast
Analysis of sweetness and CBD
It is easy to use, cuts down a lot of running time.
Review Date: 4 Feb 2022 | Waters
Great sensitivity, stable and easy operation and maintenance
Pesticide Residue Analysis
Great sensitivity, stable and easy operation and maintenance
Review Date: 22 Dec 2021 | Waters
Right now, we can not be without it. Saves a lot of time and solvents.
Sweetness compounds
Great UPLC system, the pressure can go up to 15000psi. Fast running time. Most compounds can be separated in 5 min. It is a good instrument for routine analysis and research projects.
Review Date: 16 Jul 2021 | Waters
East to use, robust.
Pharmaceuticals
I have used Waters, Agilent and Shimadzu instruments, and from experience I can say that Waters is more robust and user friendly.
Review Date: 15 Jul 2021 | Waters
Reliable instrument with wide solution support.
Assay, impurity, and dissolution rate
Very effective and efficient work horse for formulation screening during drug product development.
Review Date: 15 Jul 2021 | Waters
Versatile performance, legendary service and support!
Small molecules
Our first H-Class was purchased over ten years ago. Since, we've added three more H-Class systems and three ARC systems. All are reliable with minimum downtime. Service and support from Waters is outstanding! No other provider comes close to their level of expertise, availability and dedication. Lab costs are down and productivity increased, due in no small part to Waters instrumentation and service.
Review Date: 15 Jul 2021 | Waters
Unbeatable choice for any pharmaceutical laboratory!
Pharmaceuticals
Highly reliable equipment, very clear and efficient software and easy to use. Although for analysts which are used to other softwares and instruments it may seem more complex, in reality its robustness, clarity, and huge potential in performing all calculations and reporting configuration, makes analytical tasks much easier. The technical support is of high quality and reliability, and it is usually very fast. Acquiring parts is also very straightforward and stress free. Going from HPLC to UPLC mode, for those who are starting, is easy with this hybrid, as the instructions are clear and effective. To sum up, it makes the analytical work much easier, faster and more reliable.
Review Date: 15 Mar 2021 | Waters
Awesome customer care!
Cannabis
Waters Corporation has extensive resources for scientists using their product. Their customer care is extraordinary. Industry consultants, chromatography experts, and even their sales associates have visited my laboratory to help me learn and use this instrument. As a recently-graduated scientist I am very appreciative of the services Waters has provided.
Review Date: 9 Feb 2021 | Waters
Transform standard procedures into ultimate performance.
The ACQUITY UPLC H-Class PLUS System is the next evolution of UltraPerformance instrumentation, providing the highest resolution of any quaternary or binary LC System. Achieving true UPLC performance requires that system dispersion (or extra-column band spread) to be matched to the peak widths associated with narrowbore columns packed with sub-2-μm particles. While other systems might be designed for high pressure, it doesn’t mean they're designed to deliver the sharp peaks associated with UPLC performance and the ACQUITY UPLC H-Class PLUS System.
Choosing the ACQUITY UPLC H-Class PLUS System enables you to continue running existing HPLC methods on a forward-looking LC platform, allowing you to confidently and seamlessly transition to UPLC separations - when you’re ready - using integrated system tools and reliable column kits for method transfer and method development that simplify migration. And, when paired with the ACQUITY QDa Detector, you can combine qualitative and quantitative data into the same workflow with complementary optical and mass detection.
ACQUITY UPLC H-Class PLUS System Features:
- Flexibility of automated quaternary or binary solvent blending
- Simplicity of flow-through-needle injections
- UPLC resolution, sensitivity, throughput
- Seamlessly transfer methods from HPLC to UPLC, and back
- Runs HPLC until you’re ready for UPLC
- Ideal for method development
Brochures
The ACQUITY UPLC H-Class PLUS from Waters
In this brochure, Waters introduces the ACQUITY UPLC H-Class PLUS, with Empower 3 Software that is designed to enable quicker run times to maximize your productivity.
Determination of vitamin D and previtamin D in food products
This application note demonstrates an improvement in the current LC-MS method for vitamin D analysis. It demonstrates the determination of total vitamin D by individually measuring the vitamin D and previtamin D in food products. Previtamin D was directly measured in the total vitamin D analysis, eliminating the error that could arise from not measuring previtamin D. This method will be less affected by the heating history of food products.
Analysis of organic acids using a mixed-mode LC column and an ACQUITY QDa Mass Detector
Organic acids (OA) are an important group of compounds for many industries including food and beverages, animal feeds, and human health. Download this application note to see how the performance characteristics of the analytical method, including the limit of quantitation (LOQ), the relationship between the chromatographic peak area and concentration, the precision, and the accuracy have been evaluated.
Analysis of sucralose in beverages using an ACQUITY UPLC H-Class PLUS with the ACQUITY UPLC refractive index detector
This application note highlights a method for the analysis of sucralose using an ACQUITY UPLC H-Class PLUS coupled with an ACQUITY Refractive Index Detector. Combined with a CORTECS™ T3 Analytical Column and Empower™ 3 Chromatography Data System, this set-up provides a simple isocratic method for the determination of sucralose in beverages, such as soft drinks and energy drinks.
Fast, accurate and flexible LC-PDA method for the determination of citric acid in beverages
Citric acid is used as an additive in many beverages to improve taste and flavor as well as an antioxidant. In this application note, Waters describes an analytical method for citric acid that has been developed using the ACQUITY Premier CSH Phenyl-Hexyl Column, with the ACQUITY UPLC H-Class System coupled with an ACQUITY UPLC PDA Detector.
Agilent 1290 Infinity II LC with ISET–Emulation of the Waters Acquity H-Class for Ternary Gradients
This application note shows how the 1290 Infinity II LC with ISET emulates the ternary gradient of a Waters Acquity H-Class system for the analysis of peptides. Download the application note below and find out how the 1290 Infinity II, can take your HPLC research to new heights, and how, with the use of the Acquity H-class, peptide analysis is easier than ever.
Discover the power of more with the ACQUITY QDa Mass Detector
Download this infographic to explore the features and benefits of the Waters ACQUITY QDa Detector and learn how integrating one into your existing chromatography workflows could help your lab achieve even more.
Development of a robust method for analysis of aspirin and related substances
In this application note, Waters Corporation presents an MS-compatible method for the analysis of aspirin active pharmaceutical ingredient (API) and its related substances using a Fusion QbD method development software.
Download the full note below to explore how using this software in combination with the ACQUITY Arc System and Empower CDS can enable analytical laboratories to quickly develop reliable and reproducible analytical methods.
CRO accelerates laboratory start-up for formulation development and analytics
Download this case study to discover how, with the help of Waters instrumentation, software, and support, RaDes was able to quickly launch its new CRO laboratory for analytical method development and the design, evaluation, development, and analysis of formulations.
Multi-residue method for analyzing pesticides in cannabis using UPLC-MS/MS and APGS-MS/MS
In this application note, Waters present the use of a simple sample extraction and d-SPE clean up where the resulting extract is analyzed by UPLC-MS/MS or APGS-MS/MS in a manner that complies with Canadian regulatory requirements. A single workflow for the multi-residue analysis of pesticides in cannabis is demonstrated.
UPLC separation for the analysis of cannabinoid content in cannabis flower and extracts
As the legalization of cannabis for both medicinal and recreational use continues to advance, the need for simple, reliable analytical methods for the analysis of these products is desired by many parties. In this application note, Waters present the modification of a simple isocratic HPLC separation of 16 cannabinoids to a separation under ULC conditions.
Open Access Analytical Laboratory Provides State-of-the-Art Liquid Chromatography and Mass Spectrometry Technologies for Pharmaceutical and Life Science Researchers
Chris Howson, Open Access Lab Manager, BioCity Laboratory Services, describes the analytical technologies available to scientists working in the pharmaceutical and life science industries at the BioHub, Alderley Park, UK, including Waters ACQUITY QDa® Mass Detector, ACQUITY UPLC® H-Class System and ACQUITY UPC2® System.
Identification and Characterization of Proteins and Small Molecules in Biological Systems using Mass Spectrometry
Watch this video to discover how the TOF mass spectrometers from Waters have led to advances in proteomics and metabolomics at Colorado State University. Their robustness and speed allows for non-targeting metabolite identification which has transformed agricultural breeding approaches.
Discover the LC System Portfolio from Waters
In this video learn about the Waters portfolio of LC Systems that provide reliability, robustness and reproducibility to meet your application goals. The alliance HPLC provides consistent results, the Acquity Arc offers the flexibility to run both HPLC and UHPLC methods, and the Acquity UPLC H Class system improves lab efficiency.
Improve Method Development with the Acquity H-Class System and Empower 3 Software
Watch this video to learn how to improve method development using the Acquity H-Class system with Empower 3 chromatography data software. To learn more, click on the 'visit website' link below.
The Benefits of Automated Preparation of Mobile Phases using Auto Blend Plus
Watch this video to learn about the automating optimization of mobile phase pH for LC-UV-MS analytical methods. To find out more, click on the website link below.
Using Small Modifications of pH in Chromatographic Methods Development
Paula Hong discusses ways to make the development of chromatographic separations more effective and more efficient by focusing on the effect of pH. AutoBlend Plus enables pH values to be programmed and run automatically with the ACQUITY UPLC H-Class.
ACQUITY QDa: Method Development for Impurity Analysis
In this video, Margaret Maziarz discusses impurity analysis of a USP method using the ACQUITY UHPLC H-Class Systems and the ACQUITY QDa Detector. The system pairs UV and mass detection to track and identify sample content.
Northeastern University and Waters Team Up to Provide a Novel Solution for Studying Protein Conformation
In this video John Engen, an Associate Professor of Chemistry and Chemical Biology at Northeastern University, discusses his work studying protein conformation in cancer and other diseases. John explains how he worked with Waters to develop an instrument that enables him to perform his difficult analyses at exceptionally low temperatures. This video provides an example of how academia and industry can work together to advance scientific research.
RASID lab sets new standard for wastewater-based health surveillance
Scientists from Abu Dhabi’s RASID lab provide an insider’s look at the high-throughput wastewater analysis facility
Enhancing LC-MS analysis of oligos, peptides, and glycans using hybrid surface technology: Your questions answered
Watch this on-demand webinar to learn about the advantages of a new hybrid surface technology in mitigating problematic metal interactions
How to choose the best LC autosampler design for your application needs – on demand webinar
Experts Dr. Paula Hong and Jennifer Simeone review how each autosampler aliquots and delivers the sample and discuss their differences
Choosing the best UPLC system for your application – quaternary versus binary systems
In this popular on-demand webinar, learn more about which applications may benefit from a particular pump and how to select an LC system based on your application needs
Trending in Lab Essentials: Reducing Hands-On Time for Basic Processes in Your Lab
Free up your time in the lab for the work that really matters
Which UPLC System is Best for Your Application Needs?
Experts share tips on how to choose between quaternary and binary UPLC systems in our webinar later on Thursday, July 11
How to Overcome Current Challenges in Amino Acid Analysis
Watch this on-demand expert webinar to learn about a revolutionary new LC-MS based amino acid analysis kit for physiological samples and get results fast
Kairos: A Total Solution to Overcoming Challenges in Amino Acid Analysis
Join this webinar to discover how to bring mass spectrometry detection to amino acid analysis for unmatched accuracy
An Introduction to the Method Lifecycle Management Approach
In this Q&A from our popular webinar, learn about an analytical procedure implemented by the pharmaceutical industry and how it can benefit your lab
An Introduction to Analytical Procedure (Method) Lifecycle Management: Register for Our Upcoming Webinar with Experts from the US Pharmacopeia and Pharmaceutical Industry
Learn about the benefits of the Method Lifecycle Management approach and how to implement this approach in your lab
