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9-cis Retinoic Acid by STEMCELL Technologies Inc.

Manufacturer STEMCELL Technologies Inc.  |   Model: 72382
Retinoid pathway activator; Activates retinoic acid receptor (RAR) and retinoid X receptor (RXR)
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9-cis Retinoic Acid

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9-cis-Retinoic acid activates all isoforms of the retinoic acid receptor (RAR) (Ki = 0.5-27 nM) as well as retinoid X receptor (RXR) isoforms (Ki = 3.8-12 nM) (Umemiya et al.; Wong et al.). The ability of RAR to heterodimerize with RXR, and the latter to heterodimerize with other partners allows 9-cis-retinoic acid to evoke a wide range of effects (Dawson et al.; Kane).

DIFFERENTIATION

  • Increases the number of neurons derived from rat neural stem cell cultures (Laeng et al.).
  • Promotes oligodendrocyte precursor cell differentiation and myelination in cultured cells and mouse cerebellar slices (Huang et al.).
  • Induces formation of pancreatic ducts, but not acini, in embryonic mouse pancreas grown in collagen gel (Kadison et al.; Kobayashi et al.).
  • Enhances BMP9-induced osteogenic differentiation of mesenchymal progenitor cells, in vitro and in vivo (Zhang et al.).
  • Induces myogenic differentiation of C2C12 myoblast progenitor cells (Zhu et al.).

CANCER RESEARCH

  • Inhibits proliferation of Epstein-Barr virus-infected lymphoblastoid cell lines (Pomponi et al.).
  • Inhibits growth of cultured human gastric cancer cells (Naka et al.).
  • Inhibits spontaneous proliferation and CD40-induced growth in primary mantle cell lymphoma cells (Guidoboni et al.).

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