Waters Alliance™ HPLC System
An integrated HPLC system that works as hard as you do, available with push-button mass detection for the chromatographer. The Alliance™ HPLC System is the flexible and reliable workhorse that meets your fundamental HPLC separation requirements. The system has been continually expanded and perfected to accommodate an enormous range of real-world analytical challenges, culminating in today’s new industrial design which signi…
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It's accurate and user friendly device
Analytical chemistry
This device is trustful tool for analytical uses, plus it's software has user-friendly environment, that help user control the device
Review Date: 21 Jul 2025 | Waters
Good to have in lab for reliable results.
Drug and API testing
Waters Alliance HPLC refers to high-performance liquid chromatography equipment produced by the company Waters Corporation, it's a well-known brand in the analytical instrumentation field. Waters is recognized for manufacturing high-quality HPLC systems. Good value for money with reproducible results.
Review Date: 20 Jan 2024 | Waters
Precise, reproducible and accurate results.
Method development for samples
Product quality is consistent it gives a precise, reproducible and accurate results. It is very useful for the analysis of other compounds.
Review Date: 7 Dec 2023 | Waters
Fast analytical tools, worthy in all terms
for impurity Identification and characterisations
For the impurity profiling, in terms of identification, separation, and characterization, this is a really excellent system
Review Date: 3 Oct 2023 | Waters
Very Robust and User Friendly
Instrument Qualification
These Instruments are very sturdy and very reliable.
Review Date: 1 Sept 2023 | Waters
Nice for production
For separation of biomolecules and phenolics
Products is very good for separation of phenolic, flavanoids and aflatoxin
Review Date: 29 Jun 2023 | Waters
Awesome results and robust system with fully compliant system.
Analyse API in drug and calculate drug potency and content uniformity etc.
This is very effective product for every aspect of analysis either drug assay or content uniformity or impurities testing. Reproducibility and repeatability results always found within 1% RSD. 21 CFR compliant system with Empower 3 software. System is very robust and rugged and minimum service required for repairing and maintenance.
Review Date: 6 Jun 2023 | Waters
In nutshell, system is god and effective
ANALYTICAL METHOD DEVELOPEMNT
The instrument has user-friendly features that makes the user to effectively utilize its capability and technicality to expedite method development activity. Water's HPLC system connected with empower software has much advantage in terms of operation, acquisition of data, review and processing of data is much easier and faster. The system has salient features with robust pumping mechanism that delivers accurate gradient composition of mobile phase and hence, accuracy of gradient methods is not compromised. The sensitivity of instrument is good and thus support for the estimation of impurities present at lower level with precision and good repeatability. Reproducibility from one system to another system is excellent. The another advantage is percentage of relative standard deviation for replicate injections of standard solution which is as low as less than 0.7 %.This feature supports users to meet current United states pharmacopeia recommended limits. The additional feature of injector mechanism and design helps lot in reducing carryovers/ contamination s from previous injections or samples and thus the quality of analysis is not compromised. More importantly, the Waters Alliance Separations Module has a low total system volume, <650 mL, with excellent performance. This system produces accurate gradients with good eluent mixing, and excellent retention time reproducibility. Unit to unit consistency has been designed into the Alliance, making gradient methods transfer easier These HPLC Systems are used to transfer an HPLC method for impurities analysis from an Alliance System, successfully replicating the quality of chromatographic separation. The relative retention times are comparable, eliminating the need to make manual dwell volume adjustments for effective method transfer
Review Date: 15 Apr 2023 | Waters
Very recommended.
Pharmaceuticals (solids)
Very easy to learn how to use. Very robust. Very recommended. We have had more than 100 units since 1998.
Review Date: 27 Mar 2023 | Waters
Yes :)
Pharmaceutical Analysis in Reference Laboratories of Egyptian Drug Authority
Very easy to use, after sales care, higly recommended in all branches of analytical techniques, in my experience in different brands and my own point of view it is the perfect HPLC equipment ever.
Review Date: 12 Feb 2023 | Waters
An integrated HPLC system that works as hard as you do, available with push-button mass detection for the chromatographer.
The Alliance™ HPLC System is the flexible and reliable workhorse that meets your fundamental HPLC separation requirements. The system has been continually expanded and perfected to accommodate an enormous range of real-world analytical challenges, culminating in today’s new industrial design which signifies Waters’ commitment to HPLC and our HPLC line. Today, users can extend the Alliance HPLC System’s performance with XP 2.5 µm Columns. XP Columns are compatible with both HPLC and UPLC technology and are designed to not only improve our HPLC productivity, but also facilitate a transfer to UPLC Technology platforms as well. Directly scalable between UPLC and HPLC particle sizes, these new 2.5 um XP Columns bridge the gap between HPLC and UPLC performance.
Whether your lab analyzes samples in the pharmaceutical, chemical, food safety, environmental, or quality control arenas, the Alliance HPLC system offers you a field-proven solution. Integrated solvent and sample management to ensure consistent system-to-system performance and high reproducibility.
Waters Alliance™ HPLC System Features:
- Full integration with either Empower® or MassLynx® Software for instrument control and data processing
- A large, intuitive LCD-based user interface allows rapid system set-up through SystemPREP routines that streamline daily start-ups
- Easy, tool-free maintenance resulting in maximized uptime
- Waters complete line of detection technologies – from routine UV/Vis detectors, to the ACQUITY QDa Detector to single, tandem and triple quadrupole mass spectrometers - extend your application capabilities
Demonstration of USP Quetiapine Fumarate Impurities Method Across a Wide Range of LC Systems
In this application the USP quetiapine fumarate impurity method is analyzed on three different LC systems including the Alliance HPLC System, the ACQUITY Arc UHPLC System, and the ACQUITY UPLC H-Class PLUS System. The successful execution of the method on each system will be evaluated based upon the system suitability requirements listed in the USP monograph.
Transfer of USP Assay for Quetiapine Fumarate Across Different LC Systems
In this study, the USP assay method for quetiapine fumarate, an anti-psychotic drug, will be evaluated on a range of systems including an Alliance HPLC System, an ACQUITY Arc UHPLC System and an ACQUITY UPLC H-Class PLUS System. The USP method for quetiapine fumarate was successfully transferred across three systems: an Alliance HPLC System, an ACQUITY Arc UHPLC System, and also an ACQUITY UPLC H-Class PLUS System. All three instruments were able to reproduce the percent of quetiapine fumarate in an unknown sample and meet system suitability requirements, including resolution, tailing factor, and repeatability specifications required by the USP quetiapine fumarate assay method.
Scaling of a USP Assay for Quetiapine Fumarate Across Different LC Systems
In this study, the Waters Columns Calculator will be used to scale the USP monograph assay method for quetiapine fumarate an anti-psychotic drug, to smaller particle sized columns.
Utilizing the method scaling guidelines within the USP General Chapter <621>, traditional isocratic HPLC methods are capable of being scaled to columns with smaller particle sizes and shorter lengths. Scaling a USP method enables the use of modern chemistries and LC hardware to deliver improved throughput with decreased solvent consumption all while providing accurate and reproducible chromatographic data. The scaled modifications for the USP quetiapine fumarate assay method enabled the original method run time to be reduced by 57% for a 3 μm column on an ACQUITY Arc UHPLC System and 87% reduction for the 1.7 μm column on an ACQUITY UPLC H-Class PLUS System. The scaled methods maintained the same or improved chromatographic performance in terms of resolution, peak tailing, and retention time and peak area RSD.
Future-Proof Solutions for Regulated Laboratories in the Face of Changing USP <621> Guidelines
This white paper discusses how to leverage the changing USP <621> guidelines with established methods, while providing options to immediately improve results and illustrate how to achieve long-term return on investment (ROI). By staying within allowable adjustments, significant benefits may be realized with only verification of the suitability of the method for its intended purpose, rather than a full revalidation.
Waters Analytical Liquid Chromatography Portfolio Infographic
Do you know which quaternary liquid chromatography technology is best for your analysis? This infographic presents the Waters Analytical Liquid Chromatography Portfolio and helps you decide which combination of dispersion system, column and technology is right for your analysis and budget.
Point-Of-Use (POU) Polishers for the Production of High Purity Water Tailored to Specific Analytical Needs
This poster presents the results of experiments that were carried out to qualify POU polishers. In order to meet the unique requirements of specific analytical applications, three POU polishers were developed and designed to be installed at the outlet of a water purification system: (1) LC-Pak® polisher for HPLC, LC/ MS, LC/MS/MS, UPLC analyses, (2) VOC-Pak™ polisher for the Volatile Organic Compounds (VOC) analyses, and (3) EDSPak® polisher for analyses involving endocrine disruptors (EDs). The GC-MS and LC-MS data show their efficiency in eliminating contaminants specific to the application for which they were intended.
A Practical Guide to the Effects of Water Purity On HPLC, LC-MS and Related Techniques
This guide from demonstrates the importance of using freshly produced ultrapure water to optimize performance when using liquid chromatography. The guide also contains general information about liquid chromatography, water purification technologies and how to avoid contamination.
Point-Of-Use (POU) Polishers for the Production of High Purity Water Tailored to Specific Analytical Needs
This poster shows the results of a study to qualify three Point-Of-Use (POU) polishers by showing their efficiency in eliminating contaminants. The three POUs tested were the LC-Pak® Polisher for HPLC, LC/ MS, LC/MS/MS, UPLC analyses, the VOC-Pak® Polisher for the Volatile Organic Compounds and the EDS-Pak® Polisher for analyses involving endocrine disruptors (EDs).
Size Exclusion Chromatography for the Analysis of Small Proteins and Peptides
This application note from Waters Corporation looks at the features and advantages of the 125Å pore size, 3.5µm particle size BEH SEC column designed for separation of small proteins and peptides. This column has been made specifically to be used on classic HPLC instrumentation, and provides column-to-column reproducibility and column stability.
Amide-Bonded BEH HILIC Columns for High Resolution, HPLC-Compatible Separations of N-Glycans
This application note demonstrates that BEH Glycan Columns packed with 1.7, 2.5, and 3.5 μm particle sizes afford scalability between glycan separations performed under UPLC and HPLC-compatible conditions.
How a focus on quality is driving efficiency in the QC lab
In this video debate, Fernando Bustos, senior quality manager at Perrigo, and Adriana Tirado, market development specialist at Waters, discuss topics on the importance of QC, meeting regulations, chromatography solutions and how Waters can help you overcome challenges associated with QC.
Discover the LC System Portfolio from Waters
In this video learn about the Waters portfolio of LC Systems that provide reliability, robustness and reproducibility to meet your application goals. The alliance HPLC provides consistent results, the Acquity Arc offers the flexibility to run both HPLC and UHPLC methods, and the Acquity UPLC H Class system improves lab efficiency.
Method Transfer Made Easy with Waters
Watch this video to learn how to easily transfer methods from existing instrumentation to the Waters ACQUITY and Alliance systems. For more information, click on the website link below.
Waters introduces next-generation HPLC system
The new Alliance iS HPLC system is aimed at reducing common laboratory errors by up to 40%
‘Honest and genuine reviews are a must to consider the pros and cons of any instrument’
Virender Singh shares his work, his average day, and favorite piece of laboratory equipment
An Introduction to Analytical Procedure (Method) Lifecycle Management: Register for Our Upcoming Webinar with Experts from the US Pharmacopeia and Pharmaceutical Industry
Learn about the benefits of the Method Lifecycle Management approach and how to implement this approach in your lab
How Will Pharmacopeial Modernization Benefit Your Chromatography Workflow? Your Questions Answered
Dr. Leonel Santos and Dr. Horacio Pappa of the United States Pharmacopeia (USP) describe pharmacopeial modernization efforts in this on-demand webinar
What's The Right Liquid Chromatography System for You?
In this article, we compare quaternary LC systems to help you choose the best for your analysis needs
Webinar Highlights: Life Cycle Management of Chromatographic Methods for Biopharmaceuticals
Read the highlights from our recent webinar on chromatography for biopharma
