Vutara VXL
The Vutara VXL comprehensive biological workstation for nanoscale biological imaging incorporates Bruker’s industry-leading single-molecule localization microscopy (SMLM) technology in a streamlined system with a compact footprint. The new system enables research on DNA, RNA, and proteins and supports advanced spatial biology research. When combined with Bruker’s unique microscope fluidics unit, Vutara VXL enables multiplexed…
Vutara VXL Super-Resolution Microscope
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
The Vutara VXL is more than the leading single-molecule localization microscope (SMLM). A benchtop multimodal bioimaging workstation designed for your lab. --- Bruker’s Vutara VXL workstation with single-molecule localization microscopy (SMLM) is helping researchers greatly expand the applications of their work in biophysics, cell biology, and neuroscience. Our single molecule tracking enables the creation of high-resolution images below the diffraction limit of specifically labeled biological structures such as synapses, nuclei, viruses, cell membranes, and even whole organisms in nanoscale detail. SMLM overcomes many of the key challenges researchers face using traditional microscopy techniques by stochastically exciting individual molecules at separate time points during image acquisition for impressive high-resolution data and images. Furthermore, SMLM can be combined with other techniques, such as DNA-PAINT, OligoSTORM, and smFISH, to enable previously unobtainable data like point accumulation in nanoscale topography as well as imaging and quantifying RNA. Among super-resolution methods, SMLM offers the best improvement in resolution along with quantitative and statistical analysis capabilities.
Brochures
Super-resolution microscopy workstation Vutara VXL
In this product brochure, Bruker presents the Vutara VXL. The Vutara VXL comprehensive biological workstation enables both core facilities and individual investigators to easily incorporate super-resolution microscopy in their research. This system utilizes single-molecule localization microscopy (SMLM) technology to achieve the highest resolution of all super-resolution techniques. When combined with Bruker’s microfluidics unit, Vutara VXL enables multiplexed imaging for targeted spatial genomics, transcriptomics, and proteomics research. With advanced SRX software, researchers can transform complex data into meaningful information to explore new frontiers in disciplines ranging from neuroscience and cell biology to virology and more.
Exploring genome structure and gene expression using super-resolution microscopy
A critical step in the central dogma of biology, the flow of genetic information within a biological system, is the transcription of DNA into RNA. RNA transcripts serve certain functions within a cell, and these functions can be influenced by a variety of factors. Here, Bruker Fluorescence Microscopy highlights Dr. Guy Nir's research program which focuses on how genome structures can shape transcriptional regulation in different biological systems, utilizing super-resolution microscopy as a main technology for investigation. His lab studies this phenomenon at the single-cell level, enabling simultaneous detection of gene expression and structure that is critical for determining their relationship. This relationship between genome structure and function can be explored in a variety of biological systems, lending to several interesting research efforts transcending disciplines.
Single-molecule localization microscopy - Beyond the coverslip
Traditional microscopy methods have been used for imaging biological organization but are limited to a lateral resolution of ~200-300 nanometers. Single-molecule localization, a super-resolution microscopy approach, allows for high-resolution imaging of specifically labeled biological samples at a resolution of 20 nanometers laterally. Here, Bruker Fluorescence Microscopy summarizes the presentation given by Lauren Gagnon, Applications Scientist for Bruker’s super-resolution microscopy solutions. Presented here are the advantages and principles of single-molecule localization. Also, the unique benefits of the Vutara top-hat illumination and bi-plane technology, as well as the multiplexing capabilities supported by the microfluidics unit, are discussed. Finally, examples of imaging a variety of sample types and popular applications of single-molecule localization microscopy are presented.
Nanoscale imaging of cell-to-cell communication in the heart with super-resolution microscopy
Here, Bruker highlights Dr. Rengasayee "Sai" Veeraraghavan's research. Despite recent advances in cardiac healthcare, there are still about a half million deaths every year resulting from cardiac arrhythmia in the United States alone. A critical component of heart health is proper cell-to-cell communication via electrical signaling, a phenomenon that Dr. Veeraraghavan has been committed to researching long before his current role at The Ohio State University. During his Ph.D. studies, Dr. Veeraraghavan conducted high-speed imaging of whole hearts, labeling cardiac cells with voltage sensitive dyes and visualizing the propagation of electrical currents. This work resulted in both answers and more questions about how heart cells communicate, which led him to his first postdoc in mathematical modeling of heart signaling. It was during this experience that he realized the phenomenon occurred on a range of scales, from ~10 nanometers to one micron, and that data was lacking for many of the nanoscale structural properties that needed to be incorporated into the model.
