SPEAR UltraDetect™ NF-L Biomarker Assay Kit
The SPEAR UltraDetect™ NF-L Biomarker Assay Kit lets you quantify neurofilament light with ultra-high precision, low sample volume, and a simple, wash-free workflow. Requires SPEAR UltraDetect™ Reaction Kit. For research use only.
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A universal biomarker for neuronal injury across neurological disorders
Neurofilament Light Chain (NF-L) is a blood-based biomarker serving as a general indicator of axonal damage and neuronal injury across various neurological conditions, including Alzheimer’s disease (AD).
NF-L strongly correlates with neurodegenerative processes and amyloid pathology in AD, as measured by positron emission tomography (PET) and cerebrospinal fluid (CSF) analysis. It also acts as a broad marker of neuronal injury in conditions such as stroke, traumatic brain injury (TBI), and multiple sclerosis (MS).
The Spear UltraDetect NF-L demonstrates Unparalleled Sensitivity and Precision, measuring all healthy samples above fLLOQ with extremely low intra-plate and inter-plate CVs. Researchers leveraging NF-L desire sensitivity and precision – critical immunoassay performance metrics that enable detection of small changes in multi-year longitudinal studies while Clinical trial researcher desire the same performance benefits for applications in enrichment and pharmacodynamic studies.
Confirming this performance with clinical samples – including healthy controls and disease patient samples, the SPEAR UltraDetect NF-L assay quantified 100% of patient samples was able to achieve a mean CV% of 3.2%.
