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Simoa Homebrew Kit

QuanterixAvailable: Worldwide

pTau181 Biomarker Assay

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Quanterix’ unique homebrew capabilities provides the flexibility for researchers to develop custom Simoa^® assays. Using simple, well-established chemistry, researchers can explore significant unmet needs in life science research using digital biomarker analysis technology.

Product NewsClinical Diagnostics

Quanterix granted Breakthrough Device designation from U.S. FDA for NfL test for multiple sclerosis

Blood-based assay has the potential to serve the multiple sclerosis (MS) community in management of relapsing-remitting form of the disease

21 Apr 2022

Product NewsClinical Diagnostics

Quanterix granted Breakthrough Device designation from U.S. FDA for blood-based pTau-181 assay for Alzheimer’s Disease

The FDA’s Breakthrough Device designation is granted to products that have the potential to offer a more effective diagnosis of life-threatening diseases

10 Oct 2021

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Simoa Homebrew Kit - Quanterix - Life Sciences

Simoa Homebrew Kit

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pTau-217 Assay
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The Quanterix Simoa® ALZpath p-Tau 217 Assay provides an ultrasensitive, reliable solution for detecting phosphorylated Tau 217 (p-Tau 217) in blood. This critical biomarker is essential for Alzheimer’s research, offering insights into disease progression and helping differentiate Alzheimer’s from other forms of dementia.
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NF-LIGHT™ Simoa Assay Kit
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Neurofilament light (NF-L) is a 68 kDa cytoskeletal intermediate filament protein that is expressed in neurons. It associates with the 125 kDa Neurofilament medium(NF-M) and the 200 kDa Neurofilament heavy (NF-H) to form neurofilaments. They are major components of the neuronal cytoskeleton, and are believed to function primarily to provide structural support for the axon and to regulate axon diameter. Neurofilaments can be released in significant quantity following axonal damage or neuronal degeneration. NF-L has been shown to associate with traumatic brain injury, multiple sclerosis, frontotemporal dementia and other neurodegenerative diseases. The Simoa NF-light® assay is a digital immunoassay for the quantitative determination of NF-L in serum, plasma and CSF. The antibodies (Uman Diagnostics, Umeå Sweden) also cross react with murine, bovine, and macaque NF-L epitopes, and the assay can be used for research with these species. NF-light® is a registered trademark of Uman Diagnostics, Umeå Sweden.
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Glial Fibrillary Acidic Protein (GFAP) is a class-III intermediate filament majorly expressed in astrocytic glial cells in the central nervous system. Astrocytes play a variety of key roles in supporting, guiding, nurturing, and signaling neuronal architecture and activity. Monomeric GFAP is about 55kD. It is capable of forming both homodimers and heterodimers; GFAP can polymerize with other type III proteins or with neurofilament protein (such as NF-L). GFAP is involved in many important CNS processes, including cell communication and the functioning of the blood brain barrier. GFAP, as a potential biomarker has been shown to associate with multiple diseases such as traumatic brain injury, stroke, brain tumors, etc. Decreases in GFAP expression have been reported in Down’s syndrome, schizophrenia, bipolar disorder, and depression.
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The Simoa Human Neurology 2-Plex assay (N2PB) measures two important neurology biomarkers in both cerebrospinal fluid (CSF) and blood. The two targets are neurofilament light (Nf-L) and glial fibrillary acidic protein (GFAP™), which have been studied as indicators of traumatic brain injury (TBI) severity. N2PB has been developed as a 2-Plex version of the Neurology 4-Plex B assay (N4PB). *Banyan GFAP™ is a registered trademark of Banyan Biomarkers
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