ROCK IMAGER®
Crystal Clear Imaging. Unparalleled Speed. ROCK IMAGER ® - Crystallization Imagers are a series of automated imaging systems designed for protein crystallization screening. Capture superior quality images of your protein drops while learning critical information about your crystals. ROCK IMAGERs are available with various plate capacities and imaging features, so there is a model to fit every lab's budget and workflow.
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Good imager.
Protein crystallography
The images from the robot are great, it can work with many different plates.
Review Date: 29 Sept 2020 | FORMULATRIX®, Inc.
Great and must have in the lab for protein crystallization.
Protein crystallization
Rock Imager is an indispensable instrument for protein crystallization studies. You load the crystallization plate into the Rock Imager and it automatically records and stores pictures of the crystals on a schedule. The plate has its own barcode and can be analyzed at any time. This is very cost effective and a time saver. We highly recommend it. I would like to have another Rock Imager in my lab.
Review Date: 23 Sept 2020 | FORMULATRIX®, Inc.
Great results. Our research would be impossible without it.
Crystallization
Very easy to use and rapid screening of thousands of crystallization conditions.
Review Date: 23 Sept 2020 | FORMULATRIX®, Inc.
Great for imaging, poor for scoring hits.
Protein crystallization
This instrument is a nice tool for imaging and housing plates. The software needs major improvements especially in the scoring system when hits are supposedly found.
Review Date: 23 Sept 2020 | FORMULATRIX®, Inc.
Fantastic product support.
Protein complex crystallography
My favourite feature of the Rock Imager is the after sales support. Formulatrix take product support very seriously and have implemented many new software features based on customer feedback. This is also a fantastic labour-saving plate imaging robot. With a little training, it's easy to use, and the implementation of new features means it's even easier to use now than when we first had this in the lab. The Rock Imager is essential to our production of high quality, high resolution structural data.
Review Date: 23 Sept 2020 | FORMULATRIX®, Inc.
ROCK IMAGER® provides users:
- Systems You Can Trust
Over 15 Years of Imaging Excellence - Used worldwide by the top 25 pharmaceutical companies and renowned academic centers.
- Image Quality Second to None
Optimized Optics - Every imaging technology precisely optimized for crystal clear images.
- Ability to Increase Your Throughput
Automation Designed for Speed - Image entire 96-well plates in only 3 minutes and incubate up to 1500 plates.
- Screening Options with Various Imaging Methods to Discover More:
- Visible Light (Color)
- Cross-Polarization
- UV Fluorescence
- UV Absorption
- Multi-Fluorescence Imaging (MFI)
- Fluorescence Recovery After Photobleaching (FRAP)
- Second-Order Nonlinear Imaging of Chiral Crystals (SONICC)
- Various Models to Fit Your Budget and Workflow
Plate capacities from a single plate up to 940 SBS format plates or 1500 LCP plates
- Temperature Regulation Options Available
Precise temperature control from 30°C down to 4°C
- Multiple Experiment Plate Options Available
SBS, Linbro, Nextal, Terasaki/HLA and Lipid Cubic Phase (LCP) plate
- Seamless integration with ROCK MAKER - Crystallization Software
Multi-Fluorescence Imaging of Protein Crystals
The unambiguous and reliable identification of biological crystals remains a major obstacle in crystallography, particularly in the critical stage of initial screening experiments. Crystallographers have often relied on the intrinsic fluorescence of aromatic amino acids, such as tryptophan, to differentiate between salt and protein crystals. In some cases, proteins have very few tryptophan amino acids, or none at all, making it impossible to use UV fluorescence for imaging. The addition of a fluorescent molecule to one’s protein enables the ability to do visible fluorescence imaging and acquire high contrast images in very short imaging times with no sample damage.
Lipid Cubic Phase: Drop Setting, Condition Screening and Imaging
Integral membrane proteins are arguably the most important class of proteins in terms of their role in cellular interactions and their associated significance in disease pathways. Lipidic Cubic Phase (LCP) has emerged as an effective medium for crystallizing membrane proteins. The current pace of adoption of LCP-based methods has increased substantially, in spite of the steep learning curve associated with their implementation. This application note will discuss the three major steps of LCP crystallization and how automation technology is significantly facilitating the use of this powerful methodology.
