Cellmatic™

Built for Next-Gen Cell Culture

Cellmatic is a fully automated cell culture system that will perform your cell experiments and culture work from start to finish. Media changes are completed with the Formulatrix Reagent Exchanger that quickly aspirates spent media to waste and gently dispenses warmed media on a user defined schedule.

Cells are imaged every day and are passaged once they reach a specific confluency or on a set schedule. After incubation with a dissociation reagent, the Formulatrix general purpose, tip based liquid handler, FLO i8^® PD, mixes the cells up into suspension and performs a cell count. Cells can then be centrifuged and washed, prior to seeding into daughter plates.

The system features extensive reagent storage and is particularly adept at complex, long-term differentiation protocols tailored for iPSC culture. It supports various passaging techniques with precise liquid handling. The core includes a dynamic scheduler and intuitive software, making it easy to integrate and enhance research capabilities in laboratory settings, ensuring both efficiency and reliability.

Benefits:

• Fully Automated Cell Culture Workflow – Automates the entire cell culture process, including feeding, splitting, expansion, plating, and differentiation, allowing researchers to focus on science instead of manual labor
• Integrated Smart Hardware – The Cellmatic combines multiple liquid handlers (Flo i8 and Reagent Exchanger), an imager, storage, a refrigerator, and an incubator for fully automated cell culture, powered by scheduling software and device drivers
• High-Capacity Plate Handling – Supports up to 320 SBS-sized plates (1- to 384-well formats), enabling parallel processing of multiple cell lines and high-throughput experiments
• Intelligent Scheduling and Parallel Processing – Advanced scheduler allows multiple users and protocols to run simultaneously, automatically interweaving tasks without scripting or programming
• Versatile Application Support – Handles a broad range of workflows including stem cell differentiation, cell line development, high-throughput plating, permeability assays, and more — all on a single platform
• Smart Liquid Handling with Minimal Waste – Accommodates over 50 media and reagent solutions, stored in a sterile, refrigerated environment with low dead volumes (500 µL) and reusable tips, reducing cost and waste
• Rover Autonomous Plate Handling Fleet – Fleet of wireless, robotic plate handlers ensures gentle, spill-free transport of cell plates, reagents, and labware between subsystems, with precision and care
• Advanced Environmental and Contamination Control – Includes HEPA filtration, VHP sterilization, and fully enclosed, CO₂, temperature, and humidity-controlled incubators, ensuring optimal and sterile growth conditions
• Intuitive, Web-Based Software with Remote Access – User-friendly, no-code interface with real-time monitoring, scheduling, and data export. Access the system and receive alerts from anywhere via web-based software