Morphologi 4-ID
Rapid, automated, component-specific particle characterization in a single, integrated platform
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It's good and sensitive for True PSD identification
Particle size distribution
It's very helpful to identify the true PSD of formulation and Poly polymorphological characteristics.
Review Date: 16 Oct 2024 | Malvern Panalytical
Manufacturer's Response
Thanks for reviewing Ganesh, it’s great to hear that you’ve found the Morphologi 4-ID useful in your application.
An unique instrument to probe complex drug product.
Simultaneous physical and chemical analysis (Q3 microstructural understanding)
It is a very compact and handy system to use and operate. It offers simultaneous physical and chemical analysis to probe complex drug formulations effectively. It is a useful system for drug product development as regulatory product guidance demands synchronized morphological and chemical fingerprinting. Briefly, it is a useful system for quick and reliable analysis.
Review Date: 6 Sept 2022 | Malvern Panalytical
Morphologi 4-ID delivers detailed component-specific morphological descriptions of particulate blends through Morphologically-Directed Raman Spectroscopy (MDRS). This combines automated particle imaging with Raman spectroscopy in a single, integrated platform, providing the power to unlock complex particle characterization problems.
- Patented MDRS capability delivers representative component-specific particle size and shape data, delivering full characterization of your sample
- All the functionality of the Morphologi 4 combined with a dedicated Raman platform for both physical and chemical particle characterization in a single, automated measurement
- Automatically measures Raman spectra for hundreds or thousands of particles, saving valuable analyst time
- Intuitive software ensures suitability for experienced and non-experienced spectroscopists alike
- Easy correlation of morphological properties with chemical information provides the most comprehensive understanding of your sample
- 21 CFR Part 11 software option ensures regulatory compliance
- Adaptable workflows enable methods to be tailored to specific user or application requirements. Select particles for chemical analysis:
- manually, from particle images
- morphologically-directed, based on user-specified classifications (MDRS)
- automatically and objectively by the software
- Ability to export spectra in industry-standard format supports unknown component identification using 3rd party spectral libraries
- Tight control of laser power and acquisition time enables measurement optimization for a wide range of materials, from weak Raman scatterers to those that are thermally sensitive
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Particle morphology of wheat flour and gluten-free flour
In this application note, Malvern Panalytical utilizes morphologically-directed raman spectroscopy (MDRS), via the Morphologi 4-ID, to characterize starch and protein particles of three flour products. This technique allows particles to be differentiated by their chemical identity and subsequently characterized by size and shape.
Confirming the pharmaceutical equivalence of Oral Solid Dose (OSD) products using MDRS
In this technical note, Malvern Panalytical explores the application of the Morphologi® 4-ID and Morphologically-Directed Raman Spectroscopy (MDRS®) to bioequivalence studies. Using MDRS, two orally-administered cold and flu remedies were analyzed and compared in terms of particle size distribution, shape distribution and overall composition, prior to a further comparison between individual components within the two formulations.
Microstructure of crystals in a topical drug product
In this application note, Malvern Panalytical utilizes morphologically-directed raman spectroscopy (MDRS) with the Morphologi 4-ID to characterize two active pharmaceutical ingredients (APIs) in a topical drug product. This technique allows API components to be automatically and independently characterized within a formulation, providing information about their crystal microstructure.
8 Reasons to Upgrade to Automated Imaging
In this whitepaper, discover why automated image analysis is rapidly replacing manual microscopy for characterizing particle shape and how combining it with Raman spectroscopy adds chemical identification to your analysis.
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