Mag-Bind ® cfDNA Kit
Isolate circulating, cell-free DNA from plasma or serum using magnetic beads.
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The Mag-Bind® cfDNA Kit is designed for rapid and reliable isolation of circulating DNA from 1-4 mL plasma/serum samples. The Mag-Bind® cfDNA Kit can be processed manually with 15 mL centrifuge tubes or on automated platforms with appropriate plasticware. The procedure eliminates the need for funnels and vacuum steps providing hands-free operation in automated protocols. The uniquely formulated binding buffer from Omega Bio-tek allows for large sample volumes to be processed in automated formats with 4 mL serum or plasma being processed in a 24-well plate. The magnetic properties of the Mag-Bind® Particles CH enable fast magnetic separation, especially during steps involving large volumes. The high-binding capability decreases the amount of magnetic particles required thereby reducing the elution volume; up to 4 mL serum or plasma can be eluted in 50 µL.
Rare variant allele detection from urinary cfDNA by droplet digital PCR
Discover a complete workflow for detecting rare variants in urinary cfDNA using the Mag-Bind® cfDNA Kit and droplet digital PCR, enabling rare variant detection as low as 0.1% allele frequency.
Using ddPCR to detect rare variant alleles in cfDNA extracted on the MagBinder Fit24 Platform
Discover how a semi-automated cfDNA extraction workflow enables highly sensitive detection of rare NRAS and EGFR mutations using ddPCR — achieving detection limits as low as 0.1% allele frequency. Extraction was achieved by employing Omega Bio-tek’s Mag-Bind® cfDNA Kit (M3298) automated on MagBinder® Fit24 Nucleic Acid Purification System. Ideal for cancer research and liquid biopsy applications.
