MACSima™ Platform from Miltenyi Biotec
Explore the full potential of spatial biology
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The MACSima™ Platform, a revolutionary multiomics solution, streamlines your spatial biology research from end to end, reducing experimental workload and generating impactful data in no time. The platform's core, the fully automated MACSima System, combines high-plex spatial protein profiling with RNA detection on the same section, pushing the boundaries of what’s possible. The MACSima Platform empowers researchers to make pioneering discoveries by facilitating the identification of novel cell types, understanding their interactions, and exploring their impact on the tissue microenvironment, thereby advancing biomarker identification, drug discovery, and the development of precision immunotherapy.
- Same-section multiomics– Gain a deeper understanding of the causes and consequences of biological events by connecting phenotype with gene expression. Analyze hundreds of protein markers and dozens of RNAs within a single tissue section. The MACSima Platform is the first on the market to achieve this comprehensive capability.
- High-plex spatial profiling of proteinsand RNA – Use MICS (MACSima Imaging Cyclic Staining) technology to analyze hundreds of protein markers and dozens of RNAs within a single sample in one run. Whether you choose a compact panel of 15-20 protein markers or delve into extensive panels encompassing up to 200+ protein markers and 27 RNAs, the possibilities are vast.
- Comprehensive spatial biology platform– Count on the MACSima Platform for a complete and harmonized solution, featuring instrument, sample carriers, antibodies pretested for MICS technology, and analysis software. Miltenyi Biotec stands out as the sole provider offering this all-embracing package.
- Antibodies for highest convenience, flexibility, and reproducibility– Take advantage of the world's largest ultra-high-plex antibody portfolio for spatial biology, targeting 600+ biomarkers. Enjoy complete flexibility by choosing individual antibodies or ready-to-use 96-well plates with antibody panels. With REAscreen™ Design, you can even have personalized panels for the highest standardization, whether you require a large stock of a 30-marker panel or just a few replicates of a 100-marker panel.
- RNAsky™ Detection Probes for spatial transcriptomics – Explore RNAs alongside proteins on the same section. Offered in predefined or customizable panels, these probes unlock new targets undetectable by antibodies, like cytokines.
- Automated processing and imaging – Plan your experiment and leave the execution to the MACSima System.
- Analyze any kind of fixed sample – Image all types of fixed samples, whether tissue or single cells, and perform any analysis you can imagine.
- Intuitive analysis – Unlock the full potential of your spatial data with the MACS® iQ View Analysis Software. Its intuitive design makes analyzing vast spatial biology experiment data accessible to users of all backgrounds, enabling quick generation of conclusive and publication-ready results. It features an intuitive user interface and offers many analysis options (t-SNE/UMAP plots, heatmaps, distance mapping, …).
- Technical support and trusted scientific partnership – Receive comprehensive support from a team of field application specialists, spanning the entire spectrum – from panel design and experimental setup to data analysis. Miltenyi Biotec uses the MACSima Platform in its own research initiatives, demonstrating a profound understanding of scientists' needs and fostering partnerships on eye level.
Brochures
Explore the full potential of spatial biology with the MACSima Platform
Discover the MACSima™ Platform, a powerful solution for high-plex spatial proteomics and multiomics analysis. Built on MACSima Imaging Cyclic Staining (MICS) technology, the fully automated system enables the analysis of hundreds of protein markers — and even spatial RNA — on a single tissue section without compromising downstream applications. Ideal for exploring complex tissue environments like the tumor microenvironment, the MACSima Platform delivers unmatched flexibility, reproducibility, and insight into spatial biology.
Multiomic profiling of colorectal cancer with MICS reveals interactions between antigen-presenting CAFs and T cells
This poster showcases spatial multiomic profiling of colorectal cancer using Miltenyi’s MICS technology. Four distinct cancer-associated fibroblasts subpopulations were identified, including a novel immunosuppressive TinCAF population that interacts with immune cells. These insights into the tumor microenvironment offer new opportunities for biomarker discovery and immunotherapy targets.
From tissue sample to publication-ready results in record time with MACSima™ Platform
Explore Miltenyi Biotec's MACSima Platform, an all-in-one spatial biology solution for high-plex proteomics and RNA detection on the same tissue section. Combining high-plex proteomics and RNA detection on a single tissue section, it delivers a fully automated workflow, from sample preparation to advanced spatial data analysis, empowering researchers to achieve publication-ready results faster and more efficiently.
REAscreen™ Immuno-oncology Panel
Find out more about the versatility of the REAscreen™ Immuno-oncology Panel from Miltenyi Biotec, a predefined, plug-and-play antibody panel designed to provide insight into spatial biology of the tumor microenvironment (TME) of solid tumors.
Interpreting complex spatial biology data through unsupervised data analytics
Wednesday October 1, at 19:00 BST | 20:00 CEST | 14:00 EDT | 11:00 PDT
A single tissue section represents a cellular and molecular landscape of extraordinary complexity, waiting to be explored. However, past approaches have only tapped into a small fraction of the information hidden in their protein expression halting insights and clouding biotherapeutic discovery.
With advances in multiplexed imaging and cyclic staining technologies, researchers can now visualize dozens, and even hundreds of protein targets within a single tissue section. While this opens the door to unprecedented biological detail, it also introduces a significant challenge as we try to interpret and understand the vast amounts of data collected from the tissue.
In this webinar, Dr. Kevin Rychel-Penn, a spatial biology data scientist at Miltenyi Biotec, will demonstrate an advanced analysis workflow using 61-plex protein expression data from a colorectal carcinoma tumor microenvironment. Through cellular segmentation, dimensionality reduction (UMAP), clustering, spatial structure identification, and distance mapping, he will show how meaningful, high-impact insights can be extracted from complex tissue datasets.
Key learning objectives:
• Discover how to maximize the scientific value of your histology samples by using cyclical staining with the MACSima™ Platform on a large panel of antibodies.
• Understand how you can identify major expression patterns using unsupervised approaches to let the data guide your cell typing workflow.
• Learn how to use MACS® iQ View software to explore the spatial context of each of your cell types of interest with distance maps and structure identification.
Who should attend?
• Scientists and researchers in academia, biopharmaceuticals, biotechs and CROs who are utilizing spatial biology in their research workflows.
• Data scientists interested in unsupervised cell-typing approaches and spatial analysis methods.
• Immunologists, pathologists and cancer researchers interested in ways to explore the spatial context of tissue microenvironments.
Certificate of attendance
If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.
MACSima Imaging Platform launch
In this video, Miltenyi Biotec introduces the MACSima™ Platform, which streamlines spatial biology research by providing detailed data on the expression levels of hundreds of protein markers within the spatial framework of tissues. At its core, the MACSima System is a fully automated instrument that utilizes fluorescence microscopy. Powered by MICS (MACSima Imaging Cyclic Staining) technology and a wide range of recombinant ready-to-use antibodies, it delivers publication-ready data quickly, allowing scientists to experience the full potential of spatial biology.
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