Human Cav1.2/β2/α2δ1 Calcium Channel EZCells
Human Cav1.2/β2/α2δ1 ion channel-expressing, division-arrested cells (CHO-K1). Cat#: CT4004. Cryopreserved irradiated cells, 3 vials: 2x10E6 cells/vial. Platform validation:
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
Human Cav1.2/β2/α2δ1 ion channel-expressing, division-arrested cells (CHO-K1). Cat#: CT4004. Cryopreserved irradiated cells, 3 vials: 2x10E6 cells/vial. Platform validation:
Stem-Cell Derived Human Cardiomyocytes (hESC-CMs): Cardiac Current Expression and Utility for Detection of Complex Mechanisms of Drug Action
In this application note from ChanTest, it was investigated whether stem-cell derived human cardiomyocytes (hESC-CMs) could be a valuable tool to assess drug effects on heart rate in the absence of autonomic input. Vardenafil, a phosphodiesterase (PDE) inhibitor used to treat erectile dysfunction, demonstrates systemic side effects, including reduction in systolic and diastolic blood pressure and increased heart rate. The effect of Vardenafil on cardiomyocyte beat rate was investigated using manual patch clamping of single, isolated, hESC-CMs, and cloned HCN4 channels.
