Products & ReviewLife Sciences
EHNA
Adenosine deaminase and PDE2 inhibitor
EHNA (Hydrochloride)
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EHNA is a reversible adenosine deaminase inhibitor (IC₅₀ = 1.2 μM in human red blood cells) that also selectively inhibits the cGMP-specific phosphodiesterase (PDE2) (IC₅₀ = 0.8 and 2 μM from human and porcine myocardium, respectively, 3.5 μM in rat hepatocyte, and 5.5 μM in human platelet) (Michie et al.; Podzuweit et al.).
MAINTENANCE AND SELF-RENEWAL
- Maintains pluripotency of human embryonic stem cells in the absence of exogenous cytokines, and blocks directed neuronal differentiation (Burton et al.).
