CRISPRa crRNA Libraries
Ensure library specificity - algorithm optimized guide RNA
Arrayed library collections of synthetic CRISPR crRNA for overexpression screening of gene families, druggable, and whole human genome. Perform rapid gain-of-function studies with CRISPR activation guide RNAs and dCas9-VPR expression.
Edit-R synthetic crRNA arrayed libraries enable one-gene-per-well investigation using high-content assays to answer in-depth biological questions. Further your drug discovery, pathway analysis, or disease progression studies.
The dual screen: Parallel genome-wide CRISPRi & CRISPRa screening
Pooled CRISPR–Cas9 knock out screens provide a valuable addition to the methods available for novel drug target identification and validation. This application presents a dual-screen approach as a new screening tool for target identification and validation.
CRISPRa: Transciptional upregulation screening with genome-wide CRISPR activation
This application note presents a human whole-genome CRISPRa platform and demonstrate its effectiveness in identifying resistance genes complementary to those identified through loss-of-function screening, under vemurafenib cytostatic conditions.
