ACQUITY UPLC I-Class / Xevo TQD IVD System

In this technical note, Waters describes a test of the analytical performance of the ACQUITY UPLC I-Class/Xevo TQ-XS IVD System for the analysis of aldosterone in plasma.

The Waters ACQUITY UPLC I-Class/Xevo TQD IVD System enables the quantification of organic compounds in human biological liquid matrices. In this application note, Waters describes a test of the analytical performance of the ACQUITY UPLC I-Class/Xevo TQD IVD system for the analysis of 10,11-dihydro-10-hydroxycarbamazepine, carbamazepine, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, perampanel, phenobarbital, phenytoin, pregabalin, primidone, retigabine, tiagabine, topiramate, valproic acid, and zonisamide in plasma. Here, the Waters ACQUITY UPLC I-Class/Xevo TQD IVD System has demonstrated the capability to deliver an analytically sensitive and precise method for the analysis of antiepileptic drugs in plasma.

The ACQUITY™ UPLC™ I-Class/Xevo™ TQD IVD System developed by Waters provides the capability to precisely measure the amount of organic compounds present in human biological liquid matrices. In this application note, the analytical performance of the ACQUITY UPLC I-Class/Xevo TQD IVD System was tested for the quantitative analysis of busulfan present in plasma. The evaluation test measures the system's ability to accurately and consistently quantify busulfan in plasma samples.

This application note presents an analytically sensitive, accurate and precise measurement of corticosteroids and androgens in serum, for clinical research.

Food fraud can result in major food safety issues. Interestingly, honey is frequently subjected to fradulent mislabelling and adulteration due to it's high value as a food commodity. Traditional methods of characterization involves complex pollen analyses, which can produce erroneous and non-specific results. This application note describes the verification of honeys from different botanical origins using UPLC-MS/MS.

LC-MS/MS using data-dependent acquisition (DDA) is widely used for characterization of metabolites in drug metabolism studies. In this application note, nefazodone was incubated with rat hepatocytes and analyzed using both DDA and IMS-enabled DDA and co-eluting metabolites were characterized.

Explore the analytical capabilities of Waters LC-MS/MS technology for analytes commonly used in the areas of endocrinology and therapeutic drug monitoring (TDM) work in the clinical laboratory.

Untargeted metabolomics and lipidomics are hypothesis-generating and exploratory in nature, their purpose is to perform an unbiased screening of metabolites and lipids in biological samples, allowing us to determine patterns or variations between different groups: healthy versus diseased, control versus treated or wild-type versus genetically modified.

This application notebook explains the use of novel and unique chromatographic and spectroscopic tools and methods for metabolomic and lipidomic solutions.

Previous studies involving the excision of heart tissue from zebrafish have shown tissue to regenerate in only a few days following amputation. Detailed analysis using genomic and proteomic approaches have identified a number of potential candidates that may be implicated in the regeneration process.

This application note uses a multi-omics approach to study zebrafish plasma, rather than the excised tissue, to provide a greater understanding of the mechanisms involved in heart tissue regeneration following the operation. Lipidomic and proteomic data have been collected using a label-free LC-HDMS approach.

The bioavailability of busulfan varies greatly between individuals due to factors such as age, underlying diseases and drug-drug interactions. In this application note, an analytically sensitive and selective clinical research method has been developed for the analysis of plasma busulfan.

Waters is focused on providing you the resources you need to help you achieve your scientific goals from sample to result in the clinical laboratory.

An integrated solution with a laboratory information management system in the clinical laboratory is more important now than ever. Waters MassLynx LIMS Interface allows you to automate the transfer of clinical data with ease and without error.

Dr. Dennis Dietzen discusses the future of clinical diagnostics, and how AACC can inspire a generation of future leaders in laboratory medicine. He shares his thoughts on which technologies have made the greatest impact throughout his career in pediatric medicine and how, in a world where there’s a temptation to let electronic communication dictate, the AACC annual meeting has become one of the most important events in the field.

Clinical LC-MS workflows are often limited by time, workload, and staffing. With this in mind, Waters Corporation is committed to providing new technology that will help to meet these everyday challenges, by delivering more streamlined solutions with increased sensitivity and flexibility. At AACC 2018, Ben Dugas, Senior Global Business Development Manager, discusses how Waters' end-to-end solutions, from sample prep to data integration, are revolutionizing clinical workflows.

MassTrak Vitamin D Solution - An LC-MS/MS-based clinical diagnostic solution for quantitative assessment of vitamin D deficiency. Measure 25(OH)D2 and 25(OH)D3 independently and accurately with this complete CE-marked assay for IVD use. (Not available for sale in all countries.)

Explore exclusive interviews, methods, and free downloads to help you optimize your mass spectrometry experiments

Dr. Emma Walker reveals how transitioning from immunoassays to LC-MS/MS has helped deliver better diagnostic services in her lab

A mass spectrometry breath test, artificial intelligence algorithms and novel anti-inflammatory compounds among the innovations that could pave the way for better diagnoses and treatment

A mass spec scientist, from a world-renowned clinical pathology laboratory, shares the secrets to their success in this exclusive SelectScience interview

New system promises to deliver antibiotic susceptibility testing results in two hours to help avoid misuse of antibiotics in suspected sepsis patients

Immunology-focused pharma company INmune Bio is set to start first-in-man clinical trials with a promising anti-TNF compound that could revolutionize the treatment of Alzheimer’s disease and related symptoms

Expert in mass spectrometry for therapeutic drug monitoring shares research goals and future predictions

Dr. Leonel Santos and Dr. Horacio Pappa of the United States Pharmacopeia (USP) describe pharmacopeial modernization efforts in this on-demand webinar

How scientists at Birmingham Women’s and Children’s Hospital have integrated the latest advancements in clinical mass spectrometry to provide better treatment for serious metabolic disorders