6495D triple quadrupole LC/MS (LC/TQ)

In this application note, we demonstrate the potential of a state-of-the-art triple quadrupole LC/MS system for researchers to push the boundaries of protein biomarker discovery in this emerging frontier. A comprehensive targeted quantification assay for 1,000 proteins in human K562 cell lysate was developed using an enhanced nanoflow LC/TQ platform. The system integrates the Evosep One LC, Newomics UniESI ion source, and Agilent 6495D triple quadrupole mass spectrometer. The results show excellent quantification performance, enabling reliable protein quantification at an extremely low amount, approximating single-cell level detection

Discover the power of a high-throughput, automated workflow combining the Agilent 6495D triple quadrupole LC/MS system with Bravo-based solid-phase extraction (SPE). Designed for researchers and bioanalytical labs, it demonstrates how to achieve ultra-sensitive, reproducible quantification of therapeutic oligonucleotides in complex biological matrices, ideal for pharmacokinetic and toxicology studies.

System robustness is of utmost importance, especially when analyzing samples for routine, in-production types of analyses; and the analysis of a large population of samples is necessary for good population statistics. Agilent details the results obtained from nonstop injection of sample in a dirty matrix, spanning over 2,000 injections, and 16 days of nonstop operation of an Agilent 6495D LC/MS system. Discover how features of the 6495D LC/MS, such as VacShield and iFunnel technology, and instrument intelligence, allow for a high-performance, highly sensitive analysis while being robust and rugged enough to withstand effects of deposition from complex and dirty sample matrices.

In this scientific poster, Agilent Technologies introduces Intelligent Reflex, a data-dependent worklist reinjection logic system built into MassHunter 12 for LC/TQ and LC/QTOF. The poster showcases the Fast Screening workflow and its potential to increase productivity for large sample batches.

In this application note, Agilent addresses the concerns regarding per- and polyfluorinated alkyl substances (PFAS) in the environment. Agilent demonstrates the effectiveness of the fourth generation iFunnel technology (G6495D) in achieving regulatory levels, emphasizing the importance of maintaining sensitivity in routine EPA 533 analysis. The new technology is compared to the earlier model, showcasing advancements in PFAS detection.

Sophisticated maintenance features on the 6495 triple quadrupole LC/MS allow you to focus on delivering reportable results – not unplanned downtime. VacShield enables quick and easy cleanup of matrix deposits on the ion injector capillary without venting the system. Early Maintenance Feedback gives you a dashboard view to visualize LC/MS instrument health and anticipate upcoming maintenance events. Scheduled tuning has your mass spectrometer ready at peak performance when you need it.

Mass spectrometry has become a reliable technique used across many applications. Recent advances in instrument intelligence, such as predictive maintenance, are now providing mass spectrometry users with the ability to streamline laboratory processes, reduce human error, and increase data accuracy and consistency. In this video, Ken Suzuki, Vice President & General Manager, Mass Spectrometry Division, Agilent Technologies, discusses how the Agilent 6495D LC/TQ and the Agilent Revident LC/Q-TOF incorporate numerous intelligence features crucial for generating meaningful scientific insights and maximizing operation time and productivity.

This video was filmed at ASMS 2023.

In this video Agilent introduces the new 6495 triple quadrupole LC/MS system. This ultrahigh-performance system has been designed for research and testing labs investigating large batches of samples. Equipped with the latest, innovative iFunnel technology, this LC/MS/MS achieves ppq-level detection limits for the most challenging analytes in heavy matrix, for example in omics, food, and environmental analysis, while providing high precision at sub-millisecond dwell times.

Gain insights from industry experts on how to approach lab digitalization and ease the transition from paper to pixels

Omics expert, Professor Gary Patti, shares his thoughts on the current trends in metabolomics and discusses how multiple omics datasets can enhance our understanding of biology and disease

The Agilent 6495 LC/TQ and Revident LC/Q-TOF LC/MS systems deliver maximum uptime, throughput, and insight to meet the ever-evolving demands of food testing

The new systems are designed to tackle challenging targeted analysis applications requiring the highest analytical sensitivity