1290 Infinity II GPC/SEC System
The 1290 Infinity II GPC/SEC System is a complete GPC/SEC analysis solution that is capable of both analytical- or microscale operation. The low-volume refractive index detector enables microscale operation, which offers several key benefits, including shorter run times for higher sample throughput, ultralow dispersion for improved resolution, and lower solvent usage and waste disposal in order to reduce costs.
1290 Infinity II GPC/SEC System
1290 Infinity II GPC/SEC microscale operation
1290 Infinity II GPC/SEC with refractive index detector
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The 1290 Infinity II GPC/SEC System is a complete GPC/SEC analysis solution that is capable of both analytical- or microscale operation. The low-volume refractive index detector enables microscale operation, which offers several key benefits, including shorter run times for higher sample throughput, ultralow dispersion for improved resolution, and lower solvent usage and waste disposal in order to reduce costs.
Coupling with the Openlab GPC software enables archiving of all data together in a single CFR compliant environment.
Features:
- Microscale operation - run times can be reduced by as much as 70%
- Improved resolution - impurities or oligomers can be detected, which are often missed when using conventional GPC
- Excellent reproducibility for consistent results
- Minimized column diameter means solvent savings up to 80% for reduced cost of analysis
- High-pore-volume columns with small-diameter particles reduce analysis time while improving resolution
- Multipore columns enable linear column calibration - preventing dislocations and distorted peak shapes
- Analytical- and microscale operation - excellent agreement between molecular weight results proves suitability to run both modes on the same system
- Your choice for performance and sustainability: The 1290 Infinity II LC System has received the My Green Lab ACT (Accountability, Consistency, Transparency) label after an independent audit to verify its environmental impact throughout the product life cycle.
High-resolution sampling 2D-LC for pharmaceutical impurity analysis
In this application note, Agilent addresses the challenge of analyzing impurities in low concentrations relative to an active pharmaceutical ingredient (API) for quality control purposes. When the impurities have structural similarities to the API and there is a significant concentration difference, achieving chromatographic separation and detection becomes difficult.
To overcome this challenge, Agilent introduces the Agilent 1290 Infinity II 2D-LC Solution, which offers the flexibility to switch between comprehensive (LCxLC), multiple heart-cutting (MHC), or high-resolution sampling 2D-LC (HiRes 2D-LC) techniques. In this specific application note, HiRes 2D-LC is utilized to separate two closely eluting compounds, with one compound present at a very low concentration and concealed beneath the more highly concentrated compound peak. The analysis involves chlorodifluorobenzoic acids as standard substances and deamidated insulin as a representative real sample.
Determination of epoxy resin polymers by GPC with the Agilent 1290 Infinity II LC
In this application note, Agilent highlights the benefits of utilizing the Agilent 1290 Infinity II micro Refractive Index Detector (RID) for gel permeation chromatography (GPC) within an Agilent 1290 Infinity II LC system. The combination of the ultra-high performance liquid chromatography (UHPLC) system with the micro RID allows for the utilization of GPC columns with narrow inner diameters of 2.1 mm. This setup results in improved resolution and reduced solvent consumption compared to a standard HPLC GPC system equipped with a standard RID.
Improved GPC with the Agilent 1290 Infinity II Micro RID
A performance comparison of the Agilent 1290 Infinity II Micro RID with the standard Agilent 1260 Infinity II RID.
