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High-resolution sampling 2D-LC for pharmaceutical impurity analysis

30 Sept 2021

In this application note, HiRes 2D-LC is used to achieve the separation of two closely eluting compounds, one of which is present at a very low concentration and is hidden under the other more highly concentrated compound peak.

Agilent 1290 Infinity III 2D-LC System

Agilent Technologies

Increase resolution where you need it with the 1290 Infinity III 2D-LC System, which offers comprehensive two-dimensional liquid chromatography (2D-LC), (multiple) heart-cutting 2D-LC analysis, and high-resolution sampling. This system allows you to use 2D-HPLC for making buffer separations compatible to MS detection, while easy-to-use software enables fast method setup and refined data analysis.

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High-resolution sampling 2D-LC for pharmaceutical impurity analysis