Waters and Wyatt Collaborate to Advance Polymer Analysis and Biopharmaceutical Characterization Studies

30 May 2017
Lois Manton-O'Byrne, PhD
Executive Editor

Waters Corporation has announced that it entered into a Co-Marketing agreement with Wyatt Technology to advance the analysis of synthetic polymers and biotherapeutic proteins. By pairing Waters®ACQUITY® UPLC® and Waters® ACQUITY® Advanced Polymer Chromatography® (APC) Systems with Wyatt’s µDAWN® Multi Angle Light Scattering (MALS) detector, R&D scientists receive higher quality information and data 5x faster than ever before.

SEC separations with high resolution and speed have not always been synonymous. However, the innovative low-dispersion system design of Waters’ UPLC systems combines with solvent agnostic small particle column chemistries to deliver unprecedented high-resolution SEC/GPC separations. The benefits of these high speed/high resolution separations are best realized with low dispersion multi-angle light scattering (MALS) detectors like the Wyatt Technology µDAWN MALS detector. When the systems are coupled, users can determine absolute molecular weights and sizes of polymers, peptides, or proteins directly, without relying solely on column calibration or reference standards.

“Waters takes great pride in collaborating with innovative companies like Wyatt Technology to solve complex molecular characterization challenges. This is an example of two leaders in our respective fields working together to optimize the combination of our respective technologies to help scientists achieve their analytical goals,” said Mike Harrington, Senior Vice President, Global Markets at Waters.

“Whether researchers seek to understand and predict material properties of polymers, or determine the absolute molecular weight and size in the characterization of biologics, this partnership improves the confidence in achieving accurate and reliable results from SEC-MALS experiments.”

“The µDAWN represents a unique detection technology for Waters’ UPLC equipment. Just adding a µDAWN to an ACQUITY APC system enables the customer to obtain absolute molecular weights without relying on tedious—and often inaccurate—column calibration reference standards.

“We’re delighted to be partnering these ‘best in class’ products to improve the accuracy and throughput of our mutual customers,” said Cliff Wyatt, Executive Vice President of Wyatt Technology.

Waters® ACQUITY ® Advanced Polymer Chromatography™ (APC™) System

Waters

Developing differentiated polymers and deploying a sustainable operation are two of the utmost challenges facing the polymer and plastics industries. Current GPC/SEC methods are limited by a lack of resolution for novel and complex polymeric entities, the time required to achieve satisfactory separation, and the volume of solvent consumed per analysis. Waters® ACQUITY® Advanced Polymer Chromatography™ (APC™) System is a breakthrough technology that defines the ultimate in size-based chromatographic separations, delivering more information about your polymers faster than ever before. This means better characterization, improved asset utilization, and a superior solution for achieving corporate innovation and sustainability goals.

(3)

ACQUITY UPLC System

Waters

Waters ACQUITY UPLC - Dramatic Improvements in Speed, Sensitivity and Resolution Whether you work in methods development or quality assurance, in drug discovery and development or testing for safety in food supplies, you seek a productivity edge. With the ACQUITY UPLC® System, now you can get more information in a single, short run than you've ever seen with HPLC. Waters ACQUITY UPLC System UltraPerformance LC® (UPLC®) technology starts with unique 1.7 μm small-particle chemistries. Chromatographers no longer need to choose between speed and resolution–with UPLC you get both. Instrument Designed for Chemistry; Chemistry Designed for the Instrument The ACQUITY UPLC System has been holistically designed to match the performance needs of our innovative column chemistries with robust hardware, easy-to-use software and specialized support services. Small, pressure-tolerant particles High-pressure fluidic modules Minimized system volume Negligible carryover Reduced cycle times Fast response detectors Integrated system software and diagnostics With UPLC you have the ability to work more efficiently with higher speed, sensitivity and resolution at a much wider range of linear velocities, flow rates and backpressures to obtain superior results. The Waters ACQUITY UPLC System's high-pressure fluidics optimizes flow rates to make the most of small particle technology. The ACQUITY UPLC System's sample-handling design is designed to ensure exceptionally low carryover and reduced cycle time. And when interfaced with the Sample Organizer, it increases unattended sample capacity by ten times. High-speed detectors, both optical and mass, contribute to increased sensitivity and help manage the heightened speed and resolution requirements of UPLC. ACQUITY UPLC Systems are easily controlled, diagnosed, and monitored via a graphical system console interface. The console offers: Quick and easy access to critical instrument parameters Simple system start-up, elegant system status monitoring and predictive performance indicators to ensure maximum productivity Data management capabilities that are supported by both MassLynx™ and Empower™ software The ACQUITY UPLC System is also supported by Intelligent Device Management technology with our Connections® INSIGHT™ service, providing instrument diagnostics.

(167)

Links

Tags