ACQUITY UPLC System

by Waters

4.1/5.0 (84 reviews)

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Waters ACQUITY UPLC - Dramatic Improvements in Speed, Sensitivity and Resolution Whether you work in methods development or quality assurance, in drug discovery and development or testing for safety in food supplies, you seek a productivity edge. With the ACQUITY UPLC® System, now you can get more information in a single, short run than you've ever seen with HPLC. Waters ACQUITY UPLC System UltraPerformance LC® (UPLC®) technology starts with unique 1.7 μm small-particle chemistries. Chromatographers no longer need to choose between speed and resolution–with UPLC you get both. Instrument Designed for Chemistry; Chemistry Designed for the Instrument The ACQUITY UPLC System has been holistically designed to match the performance needs of our innovative column chemistries with robust hardwa...Read more

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Reviews

83 Scientists have reviewed this product


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Average Rating: 4.1

Ease of use
4 out of 5
After sales service
4 out of 5
Value for money
4 out of 5
Rating: 5.0
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money
5 out of 5
  • Review date: 20 Mar 2015

  • ACQUITY UPLC System

"This ACQUITY UPLC System supports us for drug discovery including small molecules and also testing for safety in food materials. Now we can get more information in a single, short run than usual HPLC. So it saved money, labor and supports a lots for our research. "

Rating: 4.3
Ease of use
5 out of 5
After sales service
3 out of 5
Value for money
5 out of 5
  • Review date:05 Nov 2014

  • Application Area:Pharmaceuticals

  • ACQUITY UPLC System

"This high-end sophisticated product is best suited for existing HPLC methods and also for new methods in terms of speed without compromising resolution and sensitivity. A very good tool for impurity profiling and method development. In today's fast world, where high productivity in terms of sample analysis is expected in less time this product is an apt answer. Not only it is faster but you can combine it with any detector either of Waters makes or of a different manufacturer which makes its applications even more wider which is a good value for money. And with Waters own "Empower" software it becomes easier to operate even for a novice person. A must have for each Analytical laboratory. "
Rating: 4.0
Ease of use
3 out of 5
After sales service
5 out of 5
Value for money
4 out of 5
  • Review date:13 Mar 2014

  • Application Area:Separation And Molecular Weight

  • ACQUITY UPLC System

"The instrument works fine. However its Empower software is difficult to use unless you are very familiar with it and use it every day. For molecular weight measurement, the software cannot give numbers based on individual peaks and whole chromatograph at the same time. But the after sales service is excellent. "
Rating: 5.0
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money
5 out of 5
  • Review date:28 Feb 2014

  • Application Area:Pharmaceutical

  • ACQUITY UPLC System

"We use the UPLC system in our company and we have been able to analyze our samples in a more rapid and reproducible manner. I think it is a technique that helps pharmaceutical laboratories to quickly bring to market their products. "
Rating: 5.0
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money
5 out of 5
  • Review date:23 Dec 2013

  • Application Area:Bioanalysis Of Natural Products

  • ACQUITY UPLC System

"Excellent system, Waters was the 1st on the market of UPLC so their systems are easy to use, very robust and have extremely less carry over issues with their needle in peek. The dead volume is extremely small."
Rating: 3.0
Ease of use
3 out of 5
After sales service
3 out of 5
Value for money
3 out of 5
  • Review date:25 Nov 2013

  • Application Area:Residue Chemistry And E-Fate Metabolism Chemistry

  • ACQUITY UPLC System

"The system is functional and it meets its needs for large molecule analysis, but for residue studies it has its problems with carry over. Also when control by other software besides waters there are many communication issues. It is a useful tool and it is easy to work with, but I would recommend not using it for residue chemistry, unless someone has validated the method and you know the problems from the beginning. However it is very useful connected to a ToF Mass Spec for Proteomics I have seen great results for peptide ID it tends to handle buffers better than other systems. "
Rating: 2.7
Ease of use
4 out of 5
After sales service
1 out of 5
Value for money
3 out of 5
  • Review date:11 Sep 2013

  • Application Area:Amino acid analysis with AcqTag application

  • ACQUITY UPLC System

"The sample derivatization method is easy to implement. The separation of amino acids with UPLC worked immediately without any method tuning or problems. The cleaning procedure of the UPLC after other analyses is quite demanding (takes one day), so maybe not be very applicable if the instrument is used also for other analyses or at least demands good planning of the instrument use. The eluents are quite expensive and according to label suitable for use for one month after opening. Thus method is quite expensive if analyses are done rarely."
Rating: 4.3
Ease of use
4 out of 5
After sales service
5 out of 5
Value for money
4 out of 5
  • Review date:12 Aug 2013

  • Application Area:Analytical validation, QC

  • ACQUITY UPLC System

"Very good instrument, easy to use. I only used it one year ago and there were no problems with it. The technical support in Hungary is very good and the team is helpful."
Rating: 5.0
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money
5 out of 5
  • Review date:08 Aug 2013

  • Application Area:bioanalysis

  • ACQUITY UPLC System

"Very good system especially low carry over system with the peak needle. It is extremely robust, you can fix it by yourself easily without problems."
Rating: 4.3
Ease of use
4 out of 5
After sales service
5 out of 5
Value for money
4 out of 5
  • Review date:08 Aug 2013

  • Application Area:Hormone diagnostics

  • ACQUITY UPLC System

"The Waters Acquity UPLC system has been in our lab now for about 4 years and we are very satisfied with it. It is nice with very few problems. Firstly we coupled it to a Quattro Premier Mass spec, but as soon as we bought a Xevo TQS we coupled it to that one."
Rating: 4.0
Ease of use
4 out of 5
After sales service
5 out of 5
Value for money
3 out of 5
  • Review date:08 Aug 2013

  • Application Area:oncologic

  • ACQUITY UPLC System

"It is a good technique, easy and friendly to use. The software is intuitive in MS and UV and gives a high performance of resolution and a good speed. The instrument tolerates high pressure and high flow rate. I really recommend this apparatus."
Rating: 4.7
Ease of use
4 out of 5
After sales service
5 out of 5
Value for money
5 out of 5
  • Review date:19 Jul 2013

  • Application Area:pharmaceutical

  • ACQUITY UPLC System

"Great system and incredible support. The follow up and support is some of the best in the industry and the robustness of the system has been great in our applications so far."
Rating: 3.3
Ease of use
4 out of 5
After sales service
3 out of 5
Value for money
3 out of 5
  • Review date:26 Jun 2013

  • Application Area:Small molecule analysis

  • ACQUITY UPLC System

"Easy to use and rugged for method development. The system also requires minimum maintenance. However, back pressure often results in loss of target peaks."
Rating: 3.7
Ease of use
4 out of 5
After sales service
3 out of 5
Value for money
4 out of 5
  • Review date:03 Jun 2013

  • Application Area:pharmaceutical

  • ACQUITY UPLC System

"The Acquity UPLC Waters system is a great product that is relatively simple to use. The trouble shooting was not too hard and the services did a great job helping with the problem."
Rating: 4.0
Ease of use
4 out of 5
After sales service
4 out of 5
Value for money
4 out of 5
  • Review date:03 Jun 2013

  • Application Area:bioanalysis

  • ACQUITY UPLC System

"I would recommend this product as it is easy to setup and use. However, there are communication issues when you control it through non-Waters software. Waters is also very helpful for questions and additional training."
Rating: 3.3
Ease of use
4 out of 5
After sales service
2 out of 5
Value for money
4 out of 5
  • Review date:03 Jun 2013

  • Application Area:QC

  • ACQUITY UPLC System

"Allows for fast analysis of samples, however we are currently having repeatability issues. Installation is quick and easy. When working properly it will allow for quick method development and quicker sample turnaround times with little eluent use."
Rating: 3.0
Ease of use
3 out of 5
After sales service
3 out of 5
Value for money
3 out of 5
  • Review date:03 Jun 2013

  • Application Area:small molecules

  • ACQUITY UPLC System

"This is a very easy to use system. It works great and is fast. Sometimes it might have problems but it is easy to fix. It is definitely valuable for the money."
Rating: 4.7
Ease of use
5 out of 5
After sales service
4 out of 5
Value for money
5 out of 5
  • Review date:29 May 2013

  • Application Area:analysis of monomer inhibitors

  • ACQUITY UPLC System

"The instrument is useful because it shortens analysis time leading to higher productivity. It also uses smaller sample sizes and uses less solvent so it is more economical and environmentally friendly as well."
Rating: 5.0
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money
5 out of 5
  • Review date:28 May 2013

  • Application Area:Pharmaceutical Research

  • ACQUITY UPLC System

"The Waters Acquity UPLC system is the best UHPLC on the market. Their pump technology is unrivalled in the industry. Our LC run times have gone down to 1/4 of original and we save money on solvents and consumables."
Rating: 4.3
Ease of use
4 out of 5
After sales service
5 out of 5
Value for money
4 out of 5
  • Review date:28 May 2013

  • ACQUITY UPLC System

"The Waters Acquity UPLC system is great because it offers excellent sensitivity and resolution.  It is a very reliable instrument.  It is my UPLC of choice and I would absolutely recommend it to a colleague."
Rating: 5.0
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money
5 out of 5
  • Review date:28 May 2013

  • Application Area:pharmaceutical

  • ACQUITY UPLC System

"Easy to use and very quick. It has applications for environment, biological, and pharmaceutical and so on. Peak shapes are sharp and time saving."
Rating: 4.3
Ease of use
4 out of 5
After sales service
4 out of 5
Value for money
5 out of 5
  • Review date:28 May 2013

  • Application Area:bioanalytical, proteins

  • ACQUITY UPLC System

"The waters Acquity UPLC is heavily utilized daily in my laboratory for bioanalytical assays of proteins and small molecule residuals. The resolution and sensitivity that can be achieved is worth the cost. The Empower software is easy to use after a slightly difficult learning period. At first the software seemed difficult (relative to Chemstation) but now that I am using it often I prefer Empower. One great benefit is the Acquity console that controls instrument and column and has easy access to column information and literature. This instrument is critical for our success."
Rating: 3.7
Ease of use
4 out of 5
After sales service
3 out of 5
Value for money
4 out of 5
  • Review date:28 May 2013

  • Application Area:Separations

  • ACQUITY UPLC System

"Wonderful system.  Worked equally well for small molecules as well as proteins.  Reliable and easy to validate for use in a QC environment.  Handled a large volume of samples routinely and efficiently."
Rating: 3.0
Ease of use
3 out of 5
After sales service
3 out of 5
Value for money
3 out of 5
  • Review date:28 May 2013

  • Application Area:API

  • ACQUITY UPLC System

"The UPLC has been a great addition to the lab, however, it does require a lot of service. We have had to call in the vendor on several occasions to fix the check valve. When it is working properly, the instrument has been beneficial to the lab."
Rating: 4.0
Ease of use
4 out of 5
After sales service
4 out of 5
Value for money
4 out of 5
  • Review date:28 May 2013

  • Application Area:open access LC/MS

  • ACQUITY UPLC System

"This system has been robust in our walk-up LC/MS environment. The unit sees heavy use with little downtime. I would definitely recommend the Acquity Classic for anyone considering walk-up LC/MS applications."
Rating: 4.0
Ease of use
4 out of 5
After sales service
3 out of 5
Value for money
5 out of 5
  • Review date:28 May 2013

  • Application Area:biopharmaceuticals

  • ACQUITY UPLC System

"In my lab, we use the Acquity UPLC H -Class as its use in the biopharmaceutics makes it easy to run in high salt conditions. The flow path is completely steel free making it more robust against salt build up. To quantitate data, Empower makes it very easy to run many samples and process data."
Rating: 4.0
Ease of use
4 out of 5
After sales service
3 out of 5
Value for money
5 out of 5
  • Review date:28 May 2013

  • Application Area:Pharmaceutical Testing

  • ACQUITY UPLC System

"UPLC saves time by reducing the run time. It’s very efficient and uses less solvent with a faster run time. UPLC is able to produce better chromatography by providing sharp peaks and a complete resolution between many analytes that are being separated from the sample substance in question."
Rating: 3.7
Ease of use
4 out of 5
After sales service
3 out of 5
Value for money
4 out of 5
  • Review date:28 May 2013

  • ACQUITY UPLC System

"It is most efficient with a fast run time to analyze the sample. The column is very short. The peak is very sharp and narrow, the resolution is achievable within the three minutes run time."
Rating: 4.0
Ease of use
4 out of 5
After sales service
4 out of 5
Value for money
4 out of 5
  • Review date:23 May 2013

  • Application Area:pharmacueticals

  • ACQUITY UPLC System

"The instrument is easy to use, and easy to track column history with the chip. However, the system column installation is not quite user friendly. I like the fusion system that has been developed to support method development using UPLC. However, the software seems only include statistic function, but not the chromatographic basic theory. In general, I like the system. "
Rating: 5.0
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money
5 out of 5
  • Review date:13 Nov 2012

  • Application Area:Chemistry characterization

  • ACQUITY UPLC System

"Waters' UPLC and LCMS systems with the Masslynx platform offer the most reliable and versatile systems in the world. In addition to their ruggedness, Waters as a company offers outstanding after the sale service. Engineers are well trained in all aspects of their instruments and are readily available to help. In my experience, first response takes no longer than 24 hrs and a solution is reached between 24 to 72 hrs. Their telephone support is remarkable, you no longer have to leave a message and someone has to get back to you to solve your issue. The person answering the call is the person who will help and solve your issue. They also have the capability to log into your computer system to fix any problems directly from Milford. I have experience with other vendors in the same area as we also have competitors LC/MS systems and compared side to side, Waters by far tops them all."
Rating: 3.6
Ease of use
4 out of 5
After sales service
4 out of 5
Value for money
3 out of 5
  • Review date:01 May 2012

  • Application Area:Bioanalytical

  • ACQUITY UPLC System

"Instrument is easy to use (similar to Waters HPLC systems). It uses less sample as well as mobile phase. More pumps so multiple mobile phase can be used for selectivity."
Rating: 4.3
Ease of use
4 out of 5
After sales service
5 out of 5
Value for money
4 out of 5
  • Review date:26 Mar 2012

  • Application Area:Pharmaceuticals

  • ACQUITY UPLC System

"The UPLC system is very easy to use and is one of the biggest time savers on our lab. However communication issues with the autosampler are problematic."
Rating: 4.6
Ease of use
5 out of 5
After sales service
4 out of 5
Value for money
5 out of 5
  • Review date:23 Mar 2012

  • Application Area:Analytical Chemistry

  • ACQUITY UPLC System

"Fast and reliable separations on final purified compounds. Excellent software- MassLynx4.1, with intelli-start technology. High pressure capabilities coupled with great resolution."
Rating: 3.0
Ease of use
3 out of 5
After sales service
3 out of 5
Value for money
3 out of 5
  • Review date:23 Mar 2012

  • ACQUITY UPLC System

"A robust instrument, however there are no leak detectors which can be problematic in the column department. Using the Empower software for the instrument can be challenging. Technical support for the instrument has been great. Service engineers respond within 12-24 hours."
Rating: 4.6
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money
4 out of 5
  • Review date:23 Mar 2012

  • Application Area:Pharmaceutical Analysis

  • ACQUITY UPLC System

"Good equipment with very good separation. Very good technical support for technical questions. Good columns for UPLC and UPLC separations of natural products."
Rating: 3.0
Ease of use
3 out of 5
After sales service
3 out of 5
Value for money
3 out of 5
  • Review date:21 Mar 2012

  • Application Area:Pharmaceutical Analysis

  • ACQUITY UPLC System

"Operates at high pressures, up to 15,000 psi. Good resolution with a wide range of linear velocities. It has a rapid analysis time and the high resolution results in narrow peak widths and an increased signal/noise ratio."
Rating: 5.0
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money
5 out of 5
  • Review date:21 Mar 2012

  • Application Area:Analytical chemistry training

  • ACQUITY UPLC System

"Equipment is great for taking existing HPLC methods and converting them to faster more resolved UPLC methods. The system compliments nicely to UPLC H-Class in ease of use and affordability. Customer service is always willing to help when a problem arises. Service is prompt and excellent."
Rating: 4.6
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money
4 out of 5
  • Review date:20 Mar 2012

  • Application Area:Assay Analysis and Development

  • ACQUITY UPLC System

"Versatile and easy to use, even for new technicians. Excellent training program. After sales service has been quick, efficient and helpful."
Rating: 5.0
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money
5 out of 5
  • Review date:27 Feb 2012

  • Application Area:Pharmaceutical drug development assays

  • ACQUITY UPLC System

"Using the Acquity we are able to reduce analysis time and solvent usage/waste (and preparing less mobile phase takes less labtime as well). The Waters support is fantastic; their engineers 'know their stuff' and work to constantly improve the product. The resolution tends to be better with the UPLC (vs. HPLC), and I've found the instruments to be as robust as typical HPLCs. The columns will clog more easily, however I've found that a pre-column filter saves the column if there are large particulates in the sample."
Rating: 4.0
Ease of use
3 out of 5
After sales service
5 out of 5
Value for money
4 out of 5
  • Review date:19 Apr 2011

  • ACQUITY UPLC System

"We use the 1st generation/high pressure LC from Waters. There were initial problems with the 1st generation product but it works well. We have had lots of help from Waters tech service."

Description

Waters ACQUITY UPLC - Dramatic Improvements in Speed, Sensitivity and Resolution

Whether you work in methods development or quality assurance, in drug discovery and development or testing for safety in food supplies, you seek a productivity edge. With the ACQUITY UPLC® System, now you can get more information in a single, short run than you've ever seen with HPLC.

Waters ACQUITY UPLC System
UltraPerformance LC® (UPLC®) technology starts with unique 1.7 μm small-particle chemistries. Chromatographers no longer need to choose between speed and resolution–with UPLC you get both.

Instrument Designed for Chemistry; Chemistry Designed for the Instrument
The ACQUITY UPLC System has been holistically designed to match the performance needs of our innovative column chemistries with robust hardware, easy-to-use software and specialized support services.

  • Small, pressure-tolerant particles
  • High-pressure fluidic modules
  • Minimized system volume
  • Negligible carryover
  • Reduced cycle times
  • Fast response detectors
  • Integrated system software and diagnostics

With UPLC you have the ability to work more efficiently with higher speed, sensitivity and resolution at a much wider range of linear velocities, flow rates and backpressures to obtain superior results.

The Waters ACQUITY UPLC System's high-pressure fluidics optimizes flow rates to make the most of small particle technology. The ACQUITY UPLC System's sample-handling design is designed to ensure exceptionally low carryover and reduced cycle time. And when interfaced with the Sample Organizer, it increases unattended sample capacity by ten times.

High-speed detectors, both optical and mass, contribute to increased sensitivity and help manage the heightened speed and resolution requirements of UPLC.

ACQUITY UPLC Systems are easily controlled, diagnosed, and monitored via a graphical system console interface. The console offers:

  • Quick and easy access to critical instrument parameters
  • Simple system start-up, elegant system status monitoring and predictive performance indicators to ensure maximum productivity
  • Data management capabilities that are supported by both MassLynx™ and Empower™ software
  • The ACQUITY UPLC System is also supported by Intelligent Device Management technology with our Connections® INSIGHTservice, providing instrument diagnostics.

Product Overview

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ACQUITY UPLC System

by Waters

4.1/5.0 (84 reviews)
Ease of use
4 out of 5
After sales service
4 out of 5
Value for money
4 out of 5






Receive your quote directly from Waters for ACQUITY UPLC System