- Ease of use
- After sales service
- Value for money
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Description
Waters ACQUITY UPLC - Dramatic Improvements in Speed, Sensitivity and Resolution
Whether you work in methods development or quality assurance, in drug discovery and development or testing for safety in food supplies, you seek a productivity edge. With the ACQUITY UPLC® System, now you can get more information in a single, short run than you've ever seen with HPLC.
Waters ACQUITY UPLC System
UltraPerformance LC® (UPLC®) technology starts with unique 1.7 μm small-particle chemistries. Chromatographers no longer need to choose between speed and resolution–with UPLC you get both.
Instrument Designed for Chemistry; Chemistry Designed for the Instrument
The ACQUITY UPLC System has been holistically designed to match the performance needs of our innovative column chemistries with robust hardware, easy-to-use software and specialized support services.
- Small, pressure-tolerant particles
- High-pressure fluidic modules
- Minimized system volume
- Negligible carryover
- Reduced cycle times
- Fast response detectors
- Integrated system software and diagnostics
With UPLC you have the ability to work more efficiently with higher speed, sensitivity and resolution at a much wider range of linear velocities, flow rates and backpressures to obtain superior results.
The Waters ACQUITY UPLC System's high-pressure fluidics optimizes flow rates to make the most of small particle technology. The ACQUITY UPLC System's sample-handling design is designed to ensure exceptionally low carryover and reduced cycle time. And when interfaced with the Sample Organizer, it increases unattended sample capacity by ten times.
High-speed detectors, both optical and mass, contribute to increased sensitivity and help manage the heightened speed and resolution requirements of UPLC.
ACQUITY UPLC Systems are easily controlled, diagnosed, and monitored via a graphical system console interface. The console offers:
- Quick and easy access to critical instrument parameters
- Simple system start-up, elegant system status monitoring and predictive performance indicators to ensure maximum productivity
- Data management capabilities that are supported by both MassLynx™ and Empower™ software
- The ACQUITY UPLC System is also supported by Intelligent Device Management technology with our Connections® INSIGHT™ service, providing instrument diagnostics.
Application notes and news
- Determination of Melamine Residue in Water Samples by UPlC/MS/MS
- Advantages of Online 2D Chromatography for MRM Quantification of Therapeutic Monoclonal Antibodies in Serum
- Targeted Metabolomics Using the UPLC/MS-based Absolute IDQ p180 Kit
- Profiling and Quantitation of Metabolomic 'Signatures' for Breast Cancer Cell Progression
- Analysis of Free Bromate Ions in Tap Water using an ACQUITY UPLC BEH Amide Column
- Determination of Imidacloprid Residues in Bee Pollen Using Xevo TQ-S
- Direct Quantification of Acidic Herbicides in Drinking Water Samples Using Ultra-Sensitive UPLC/MS/MS Analy...
- Optimization of Trypsin Digestion for MRM Quantification of Therapeutic Proteins in Serum
- Quantitative Analysis of Multiple Psychotherapeutic Drugs in Human Serum using UPLC/MS/MS
- Assessing Authenticity of Fruit Juices Using the ACQUITY UPLC System
- A Reproducible Method for the Quantification of Pioglitazone and Two Active Metabolites - Keto Pioglitazone...
- Rapid, Reliable Metabolite Ratio Evaluation for MIST Assessments in Drug Discovery and Preclinical Studies
- Identification of Flavonoids in Complex Plant Extracts
- Direct Injection of Orange Juice for the Rapid Detection of the Fungicide Carbendazim
- Monitoring Sugar Content of Fruit Juice Using ACQUITY UPLC H-Class and BEH Amide Column Chemistry with Evap...
- Determination of Common Beta-Agonist Residues in Meat Products
- Rapid Analysis of Bisphenols A, B, and E in Baby Food and Infant Formula
- Analysis of Fat-Soluble Vitamins in Fortified Infant Formula by Standard Addition
- Extraction of Fat-Soluble Vitamins from Fortified Foods Using Oasis HLB
- A New Scientific Information System for Efficient Pesticide Residue Screening at Regulatory Limits
- Quantification of Chloramphenicol in Chicken Using Xevo TQD with RADAR Technology
- Profiling Flavonoid Isomers in Highly Complex Citrus Juice Samples Using UPLC Ion Mobility Time-of-Flight M...
- The Use of Multivariant Analysis for Early Detection of Potential Food or Beverage Adulterations
- Rapid and Simple Multi-Residue LC-MS/MS Method Development Using the Quanpedia Database
- Determination of Fruit Juice Authenticity Using High Resolution Chromatography, UV, Time-of-Flight MS, and ...
- Analysis of 13 Aminoglycoside Antibiotics in Bovine Milk by Ion-Pair Chromatography with Xevo TQ-S
- Simultaneous Extraction of Fat-Soluble Vitamins from Fortified Foods using Solid Phase Extraction (SPE)
- Rapid Detection of Pesticide Residues in Fruit Juice Without Sample Extraction
- Optimized Extraction and Cleanup Protocols for LC/MS/MS Multi-Residue Determination of Veterinary Drugs in ...
- Analysis of Polyphenols in Fruit Juices
- Fast Screening for Non-Nutritive Sweeteners Using the ACQUITY UPLC H-Class System with ELSD
- Doping Evaluation with NuGenesis SDMS and TargetLynx
- Quantitative Analysis of 11-Nor-9-Carboxy Δ9-Thc in Urine Using UPLC/MS/MS
- Therapeutic Drug Management (TDM) of Anti-epileptic Drugs - Multidrug Analysis using UPLC/MS/MS
- Quantitative Analysis of 21 Benzodiazepine Drugs, Zolpidem and Zopiclone in Serum using UPLC/MS/MS
- Comparison of Accurate Mass and Nominal Mass MS for the Simultaneous Acquisition of Qualitative and Quantit...
- Facilitating Chiral Method Development Using UPSFC/MS
- Rapid Quantification of Trace Levels of Perfluorinated Compounds
- Advancing Perfluorinated Compound Analysis Using Simultaneous Matrix Monitoring
- Automating Amino Acid Analysis Using Robotic Sample Preparation Instrumentation
- Synapt G2: Breakthrough Quantitative and Qualitative Performance for UPLC/MS and MS/MS Applications
- Characterization of Tea Seed Oil for Quality Control and Authentication
- Determination and Confirmation of Priority Pesticide Residues in Baby Food
- Characterisation of Tea Seed Oil for Quality Control and Authentication
- Rapid, Specific Analysis of Melamine and Cyanuric Acid in Infant Formula
- A Systematic Approach Towards UPLC Methods Development
- A Rapid Assay for p450 Inhibition/Induction Utilizing UPLC and Tandem Quadrupole MS
- Scaling a Separation from UPLC to Purification Using Focused Gradients
- Addressing the Challenges of Complex Mixture Analysis With Sub 2 µm Particles Liquid Chromatography: Long C...
- Qualitative and Quantitative Protein Profiling for Target Identification Studies with Drug-Induced Changes ...
- The Rapid Analysis of Anthocyanidins in Berries
- Waters and Nonlinear Dynamics to Co-Develop Next Generation Research Solutions for Large-Scale, Complex Dat...
- International Food Safety Training Laboratory Announced by Fera and Waters Corp.
- Waters Showcases ACQUITY UPLC/MS Tools for Increasing Lab Efficiency at AACC 2012
- Waters' Customers Present ACQUITY UPLC and PATROL UPLC System Success Stories at Pittcon 2010
- Waters Introduces ACQUITY UPLC H-Class System; HPLC Simplicity with UPLC Performance
- Waters Adds Fusion Method Development Software from S-Matrix to Automate LC Method Development
- Waters Introduces New Synapt G2 with Greater Power, Versatility and Speed Than Any Other High-End Mass Spec...
- Waters Celebrates Fifth Anniversary of Launch of Award-Winning UltraPerformance LC System
- Waters Introduces New Controller for ACQUITY UPLC System
- Waters Will Help You Be More! Visit us at Pittcon 2009.
- Faced with Global Acetonitrile Shortage, Analytical Labs Turn to ACQUITY UPLC to Reduce Acetonitrile Use by...
- Waters Publishes Rapid and Specific Method of Detection for Melamine in Infant Formula and Liquid Milk, in ...
Reviews
Yan Li Status: See all reviews Member since 2013 Organization: GlaxoSmithKline Read more » | RATING: 4.0 
"The instrument is easy to use, and easy to track column history with the chip. However, the system column installation is not quite user friendly. I like the fusion system that has been developed to support method development using UPLC. However, the software seems only include statistic function, but not the chromatographic basic theory. In general, I like the system. "   |
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| UTHAI KONGPATPHARNICH Status: See all reviews Member since 2011 Organization: Sithiporn Associates Co., Ltd. Read more » | RATING: 4.7
"Acquity UPLC is such a good product that can give you better sensitivity resolution & reproducibility. It uses less solvent and is faster in terms of retention time. " |
| Fernando Valle Status: See all reviews Member since 2012 Organization: Dow AgroSciences LLC. Read more » | RATING: 5.0
"Waters' UPLC and LCMS systems with the Masslynx platform offer the most reliable and versatile systems in the world. In addition to their ruggedness, Waters as a company offers outstanding after the sale service. Engineers are well trained in all aspects of their instruments and are readily available to help. In my experience, first response takes no longer than 24 hrs and a solution is reached between 24 to 72 hrs. Their telephone support is remarkable, you no longer have to leave a message and someone has to get back to you to solve your issue. The person answering the call is the person who will help and solve your issue. They also have the capability to log into your computer system to fix any problems directly from Milford. I have experience with other vendors in the same area as we also have competitors LC/MS systems and compared side to side, Waters by far tops them all." |
| Ashok Dhere Status: See all reviews Member since 2010 Organization: INVISTA Read more » | RATING: 4.0
"Fast and reliable but has some issues with injections mode with carry over. Saves money and solvent." |
| Karla Steele Status: See all reviews Member since 2010 Organization: Mead Johnson Nutrition Read more » | RATING: 4.0
"A reliable system with 90% up down. Sales/Service support through installation and start up." |
| Sam Diep Status: See all reviews Member since 2012 Organization: Abbott Laboratories Read more » | RATING: 3.6
"Instrument is easy to use (similar to Waters HPLC systems). It uses less sample as well as mobile phase. More pumps so multiple mobile phase can be used for selectivity." |
| Enrique Lawlor Status: See all reviews Member since 2010 Job Title: Marketing / Sales Discipline: Pharmacology Work Field: Pharmaceuticals / Biopharmaceuticals Organization: TEKSOL SRL Read more » | RATING: 4.3
"A great tool to transfer methods from HPLC. Saves money and is easy to use. The method validation software saves time." |
| Dr David Berberich Status: See all reviews Member since 2010 Organization: Covidien Read more » | RATING: 4.3
"The UPLC system is very easy to use and is one of the biggest time savers on our lab. However communication issues with the autosampler are problematic." |
| Jaclyn Siderewicz Status: See all reviews Member since 2010 Organization: Pfizer Read more » | RATING: 4.6
"Fast and reliable separations on final purified compounds. Excellent software- MassLynx4.1, with intelli-start technology. High pressure capabilities coupled with great resolution." |
| Jessica Marsh Status: See all reviews Member since 2010 Organization: Western Slope Laboratory, LLC Read more » | RATING: 4.3
"Great separations, fast run times, faster infusions with Intellistart." |
| Curtis Childress Status: See all reviews Member since 2010 Organization: PharMEDium Services, LLC Read more » | RATING: 3.0
"A robust instrument, however there are no leak detectors which can be problematic in the column department. Using the Empower software for the instrument can be challenging. Technical support for the instrument has been great. Service engineers respond within 12-24 hours." |
| Ivan Slacanin Status: See all reviews Member since 2010 Job Title: Laboratory Director Discipline: Pharmacology Work Field: Pharmaceuticals / Biopharmaceuticals Organization: ILIS Read more » | RATING: 4.6
"Good equipment with very good separation. Very good technical support for technical questions. Good columns for UPLC and UPLC separations of natural products." |
| Dan Tang Status: See all reviews Member since 2010 Organization: Bristol-Myers Squibb Read more » | RATING: 3.3
"Great high pressure system for impurites/degradants detection. It is expensive but the customer service is good." |
| Pradeep Sharma Status: See all reviews Member since 2010 Organization: Amneal Pharmaceuticals Read more » | RATING: 1.3
"Very sensitive, not rugged, lots of trouble shooting. Poor pump and no binary pump." |
| UTHAI KONGPATPHARNICH Status: See all reviews Member since 2011 Organization: Sithiporn Associates Co., Ltd. Read more » | RATING: 3.3
"The system gives great, reliable results. It can be transferred from conventional HPLC to UPLC with no problem." |
| Cynthia Torres-Godoy Status: See all reviews Member since 2010 Organization: Tennessee Technological University Read more » | RATING: 3.0
"Operates at high pressures, up to 15,000 psi. Good resolution with a wide range of linear velocities. It has a rapid analysis time and the high resolution results in narrow peak widths and an increased signal/noise ratio." |
| Ryan Gilmore Status: See all reviews Member since 2010 Organization: NC BioNetwork Read more » | RATING: 5.0
"Equipment is great for taking existing HPLC methods and converting them to faster more resolved UPLC methods. The system compliments nicely to UPLC H-Class in ease of use and affordability. Customer service is always willing to help when a problem arises. Service is prompt and excellent." |
| Martha Robledo Status: See all reviews Member since 2010 Organization: Tecnoquimicas S.A. Read more » | RATING: 4.6
"Versatile and easy to use, even for new technicians. Excellent training program. After sales service has been quick, efficient and helpful." |
| Celeste Frankenfeld Status: See all reviews Member since 2012 Organization: Merck Read more » | RATING: 5.0
"Using the Acquity we are able to reduce analysis time and solvent usage/waste (and preparing less mobile phase takes less labtime as well). The Waters support is fantastic; their engineers 'know their stuff' and work to constantly improve the product. The resolution tends to be better with the UPLC (vs. HPLC), and I've found the instruments to be as robust as typical HPLCs. The columns will clog more easily, however I've found that a pre-column filter saves the column if there are large particulates in the sample." |
| Viktoria Hartung Status: See all reviews Member since 2011 Organization: Almirall Read more » | RATING: 4.0
"Easy to use, has excellent software." |
| Jorge Augosto Machado Pereira Status: See all reviews Member since 2011 Organization: CQM, UMA Read more » | RATING: 4.0
"In my opinion, the price should be more competitive." |
| Balazs Kormanyos Status: See all reviews Member since 2011 Organization: TEVA Pharmaceutical Works Plc Read more » | RATING: 4.6
"Robust, efficient and fast." |
| Csaba Fodor Status: See all reviews Member since 2011 Organization: Teva Pharmaceutical Works Read more » | RATING: 4.3
"Fast and reliable instrument." |
| Ildiko Hanakne Szekely Status: See all reviews Member since 2011 Organization: Egis Plc Read more » | RATING: 4.3
"Very good equipment." |
| Marcel van Veen Status: See all reviews Member since 2011 Organization: Heineken Read more » | RATING: 5.0
"The best in UPLC." |
| Saikh Mohammad Wabaidus Status: See all reviews Member since 2011 Organization: King Saud University Read more » | RATING: 4.3
"The sensitive and very fast separation was achieved with this instrument." |
| Mohammad Khan Status: See all reviews Member since 2011 Organization: King Saud University Read more » | RATING: 4.6
"Fast, sensitive and selective." |
| Magali Moutte Status: See all reviews Member since 2011 Read more » | RATING: 4.0
"System very convenient and adapted for our use in compound management." |
| Craig Culbertson Status: See all reviews Member since 2011 Organization: Tempur Pedic Technologies Read more » | RATING: 5.0
"great resolution and speed." |
| Leonidas Perez-Estrada Status: See all reviews Member since 2011 Organization: University of Alberta Read more » | RATING: 3.6
"Really works for shortening the times on LC separations. Really sturdy and resistant for education." |
| Veronique Carrier Status: See all reviews Member since 2011 Organization: GlaxoSmithKline Read more » | RATING: 4.0
"Went from 60 minute runs to 3 minute runs. Saves a lot of time." |
| Douglas Papenmeier Status: See all reviews Member since 2010 Organization: NSWC Read more » | RATING: 3.3
"My problem is at the intersection of our IT and their computer control." |
Status: See all reviews Member since 2010 Organization: Arista Laboratories Read more » | RATING: 5.0
"Waters has helped us not only with method transfer, but also to revisit existing methods in order to improve them." |
| Olga Bershevits Status: See all reviews Member since 2011 Organization: Eli Lilly and Company Read more » | RATING: 4.0
"Problems with software." |
| Laura Blue Status: See all reviews Member since 2011 Organization: UNC-CH Read more » | RATING: 3.3
"The fittings seem to break quite frequently but the service team is quick to help." |
| Amy Stucky Status: See all reviews Member since 2011 Organization: Mead Johnson Nutrition Read more » | RATING: 4.6
"Great instrument and easy to use. The sales and application specialists have been great since purchase." |
| Krystyna Poblocka Status: See all reviews Member since 2011 Organization: Teva Canada Read more » | RATING: 4.3
|
| Patrick Kaltenbach Status: See all reviews Member since 2011 Organization: Agilent Technologies Read more » | RATING: 3.0
"Too many issues with product reliability. Performance is fine IF the instrument is running." |
| Dawn Kyle Status: See all reviews Member since 2011 Organization: Covidien Read more » | RATING: 4.0
"The instrument is very easy to use. The Empower software itself is still fairly glitchy with regards to its connectivity with Citrix servers." |
| Charles Pacheco Status: See all reviews Member since 2011 Organization: Array BioPharma Read more » | RATING: 4.0
"We use the 1st generation/high pressure LC from Waters. There were initial problems with the 1st generation product but it works well. We have had lots of help from Waters tech service." |
| Sheetal Patel Status: See all reviews Member since 2011 Organization: Bristol Myers Squibb Read more » | RATING: 4.0
"so pleased to have uhplc in our lab, it saves much time in terms of development." |
| JORGE RAMIREZ Status: See all reviews Member since 2011 Organization: Ramguz S.A. Read more » | RATING: 4.6
"Excellent system, saves money with solvents." |
| Nathaniel Hentz Status: See all reviews Member since 2011 Organization: North Carolina State University Read more » | RATING: 4.6
"Innovative technology!" |
| Serhiy Hynatyshyn Status: See all reviews Member since 2007 Organization: Bristol-Myers Squibb Read more » | RATING: 3.3
"Good robust system. Occasional autosample issues. Intergration issues with other instrument. Nickel coating contamination in mobile phase." |
| Tony Gonzalez Status: See all reviews Member since 2010 Organization: Xcelience Read more » | RATING: 4.0
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| Charles Black Status: See all reviews Member since 2009 Organization: Abbott Read more » | RATING: 5.0
"A laboratory workhorse." |
| SCOTT GROVER Status: See all reviews Member since 2009 Organization: PFIZER Read more » | RATING: 3.6
"This product has improved column efficiency and separation." |
| ANGELO FILOSA Status: See all reviews Member since 2009 Organization: BOEHRINGER INGELHEIM (CANADA) LTD. Read more » | RATING: 4.3
"A very innovative system with great customer support." |
| VICTORIA HEATH Status: See all reviews Member since 2009 Organization: PFIZER Read more » | RATING: 4.3
"I have had some troubles with reliability and Waters have tried to be helpful but they are not very quick. Nonetheless, the systems are great when they work." |
| MATTHEW ECKERT Status: See all reviews Member since 2009 Organization: COVANCE LABORATORIES, INC. Read more » | RATING: 1.0
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| WESTON BROWN Status: See all reviews Member since 2009 Organization: COVANCE Read more » | RATING: 2.3
"Application is easy but its use is difficult." |
| Alex Buko Status: See all reviews Member since 2007 Organization: Biogen idec. Read more » | RATING: 4.3
|
| Ivana Liric Rajlic Status: See all reviews Member since 2008 Organization: Xenon Pharmaceuticals Read more » | RATING: 4.0
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| Yousuf Ali Status: See all reviews Member since 2007 Organization: Univ Miami Read more » | RATING: 4.6
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