QIAGEN expands next-generation sequencing portfolio with QIAseq Normalizer Kits

Accelerating DNA library pooling for high-quality next-generation sequencing results

9 Jul 2023
James Li
Blood Banking Scientist

Product news

QIAGEN has announced the launch of the QIAseq Normalizer Kits that give researchers a fast, convenient and cost-effective method to pool different DNA libraries for best-quality results from next-generation sequencing (NGS) runs.

The QIAseq Normalizer Kit speeds up equalizing DNA concentrations across NGS libraries – so-called normalization – to 30 minutes from several hours by ending the need for quantifying DNA libraries using time-intensive and expensive procedures. It is high-throughput with an optimized protocol for parallel normalization of 96 samples, automation-friendly, and works without hazardous chemicals.

“The QIAseq Normalizer’s big strength is its ability to reliably normalize all library types across a wide range of concentrations quickly and cheaply,” said Dr. Thomas Schweins, Senior Vice President and Head of QIAGEN’s Life Sciences Business Area. “Library pooling is the key to cost-effective, high-yield multiplexed sequencing – and QIAGEN’s normalization kit is crucial for ensuring researchers get consistent and high-quality sequencing data by minimizing any uneven representation of libraries.”

Researchers can use the QIAseq Normalizer Kits with QIAGEN’s existing QIAseq library prep solutions to streamline NGS workflows – or with a range of DNA- and RNA-library prep workflows from other providers for Illumina sequencing platforms. The Kits will enable users to safely store normalized double-stranded DNA (dsDNA) libraries at –20°C for longer-term storage.

QIAGEN’s QIAseq kits have processed over four million NGS samples, enabling biomarker research, gene expression studies, viral epidemiology, and disease surveillance. From DNA and RNA sequencing to multimodal sequencing and epigenomics, the comprehensive range of QIAseq kits delivers reliable data on any sequencing instruments.

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Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.DNADeoxyribonucleic Acid (DNA) is the main component of chromosomes and the carrier of genetic information of living organisms. Find out here about PCR, NGS, ChIP-Seq, gel imaging, and many other techniques which can be used for the analysis of DNA.Library PreparationLibrary preparation is a critical step in sequencing workflows, where DNA or RNA samples are converted into libraries for high-throughput, next generation sequencing. This step ensures accurate results and minimizes biases. Explore library preparation kits in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.NGS AutomationNGS automation streamlines next-generation sequencing workflows, increasing throughput, accuracy, and reproducibility. Automated solutions enhance productivity in genomic research, clinical diagnostics, and personalized medicine. Browse peer-reviewed tools to compare products, read reviews, and get pricing.