Controlling Gas Liquid Chemistries
21 Jan 2013Using a Uniqsis FlowSyn™ flow reactor system - Sygnature Discovery, a leading provider of integrated drug discovery services to the pharmaceutical industry, has reported results demonstrating how the system allows them to perform traditionally hazardous chemistries in a controlled manner.
For example, using the proprietary FlowSyn technology with a Uniqsis GAM IIgas-liquid reactor, laboratory scientists at Sygnature Discovery, in conjunction with Uniqsis, have developed high pressure reaction protocols that have enabled them to reproducibly perform carbonylation chemistries under continuous flow through conditions.
Dr Daniel Hamza, a senior research chemist at Sygnature Discovery commented "The option to use a gas addition module has opened up a multitude of gas-liquid reaction chemistries that we can perform using our FlowSyn system". He added "The FlowSyn is a straightforward and robust piece of kit to operate. The ability to add on new reactors to the existing set-up is of particular benefit since the latest technology can be easily incorporated into our synthetic plans". In conclusion Dr Hamza said "Flow chemistry offers many advantages over traditional batch processing methods notably better reproducibility and scalability as well as enhanced safety, particularly with hazardous reactions such as nitration and carbonylation".
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FlowSyn Continuous Flow Reactor
Uniqsis LtdFlowSyn - Making Flow Chemistry Simple FlowSyn is a fully integrated continuous flow reactor with everything you need to start doing flow chemistry including reaction optimization, synthesis and scale up. To provide maximum flexibility, a wide range of mixer and reactor options are available as well as additional modules for performing multiple experiments, or sub-ambient chemistry. • Ability to perform continuous flow chemistry under microwave-like conditions (up to 260oC). • Perform sub-ambient continuous flow chemistry using the 'Cold Coil'. • Run up to 10 automated sequential experiments with the 'Automated Experiment Package'.A pair of high pressure pumps are used to deliver reagent solutions from either stock bottles or sample injection loops through a 'T'-mixer into the electrically heated flow reactors. Reactions can be heated to 260?C and 150?C in the coil and column reactor modules respectively. Back pressure regulators of up to 1000 psi are used to pressurise the system and thus perform superheating of solvents, allowing the chemist to access'microwave like' conditions with no limitation on scale. FlowSyn is very easy to use with a high resolution user interface. The user is guided through the process for setting up a flow chemistry reaction by inputting parameters for reagent volumes, temperatures and reaction times. The user can choose to collect all of the reaction plug, or only the 'steady state' part. FlowSyn will then equilibrate and run the reaction, and finally flush the system through with solvent. Throughout FlowSyn will monitor the pressure of the system, and shut down if a problem occurs allowing FlowSyn to be safely run unattended.