Collaboration on Novel Microwave-based Flow Chemistry
17 Jan 2012Uniqsis of Cambridge, UK, and WaveCraft of Uppsala, Sweden, have entered into a collaborative agreement to develop and market a new range of microwave-based flow chemistry systems that is hoped will improve efficiency when scaling up compound synthesis during drug development.
By integrating liquid handling technology from Uniqsis with microwave applicator technology and reactors from WaveCraft, the two companies will deliver flow chemistry systems that not only speed up synthetic processes and facilitate scale up, but also offer a safe solution that uses less energy than conventional approaches.
Flow chemistry and microwave synthesis systems have become well established in synthesis laboratories over the last 15 years. WaveCraft’s technology uses a novel applicator and a proprietary microwave generator based on mobile phone technology to apply microwave energy and accelerate chemical reactions. This makes it possible to effectively and safely combine flow chemistry with microwave heating. Scientists will be able to continuously change power and frequency, enabling optimization during synthesis. They will be able to scale up with no need to re-optimize conditions.
Paul Pergande, MD of Uniqsis, comments: “The WaveCraft team is pre-eminent in the field of microwave technology and we believe that their new technology shows exceptional promise. We are very excited to be working with them on this novel approach to microwave-based synthesis which offers real benefits to customers.”
Jon-Sverre Schanche, CEO of WaveCraft, adds, “We are extremely pleased that the potential of our technology has been recognized by a company well-established in the field of flow synthesis. Working together will give both companies a great opportunity to offer customers solutions that significantly increase productivity.”
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FlowSyn Continuous Flow Reactor
Uniqsis LtdFlowSyn - Making Flow Chemistry Simple FlowSyn is a fully integrated continuous flow reactor with everything you need to start doing flow chemistry including reaction optimization, synthesis and scale up. To provide maximum flexibility, a wide range of mixer and reactor options are available as well as additional modules for performing multiple experiments, or sub-ambient chemistry. • Ability to perform continuous flow chemistry under microwave-like conditions (up to 260oC). • Perform sub-ambient continuous flow chemistry using the 'Cold Coil'. • Run up to 10 automated sequential experiments with the 'Automated Experiment Package'.A pair of high pressure pumps are used to deliver reagent solutions from either stock bottles or sample injection loops through a 'T'-mixer into the electrically heated flow reactors. Reactions can be heated to 260?C and 150?C in the coil and column reactor modules respectively. Back pressure regulators of up to 1000 psi are used to pressurise the system and thus perform superheating of solvents, allowing the chemist to access'microwave like' conditions with no limitation on scale. FlowSyn is very easy to use with a high resolution user interface. The user is guided through the process for setting up a flow chemistry reaction by inputting parameters for reagent volumes, temperatures and reaction times. The user can choose to collect all of the reaction plug, or only the 'steady state' part. FlowSyn will then equilibrate and run the reaction, and finally flush the system through with solvent. Throughout FlowSyn will monitor the pressure of the system, and shut down if a problem occurs allowing FlowSyn to be safely run unattended.