Identifying novel aging genes and investigating their pathological role in breast cancer
The lifespan of mouse-inbred strains varies dramatically, indicating the genetic regulation of aging. To reveal the genetic mechanisms of aging, Dr. Rong Yuan and his team measured the lifespan of 32 inbred strains and longitudinally investigated the development and aging related phenotypes. The results suggest that the age of vaginal patency (AVP), a bio-marker of female sexual maturation (FSM), and the circulating IGF1 level, can be used as bio-markers of aging. By quantitative trait loci (QTL) analysis, combining bioinformatic methods, a group of novel aging related genes were identified, including nuclear receptor interacting protein 1 (NRIP1). Pathologic studies revealed that NRIP1 deletion could suppress the initiation and progress of breast cancer. Next-generation sequencing and single-cell RNA sequencing could significantly improve the ability to identify QTL genes and discover the molecular mechanisms of cancer.
In this webinar, join Dr. Rong Yuan and Shuyun Ding as they share how to identify novel aging-related genes and their pathological role in cancer. Plus, discover how to improve your research by using singe cell RNA sequencing and next-generation sequencing (NGS), and explore detailed applications for single-cell RNA sequencing.
Key learning objectives
- Discover how to identify novel aging-related genes and their pathological role in cancer
- Explore the principles and applications of next-generation sequencing
- Learn more about detailed applications for single-cell RNA sequencing
Who should attend?
- Scientists and clinicians with experience in NGS, biology, and genomics
Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
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